In-vitro virucidal and virustatic anti HIV-1 effects of extracts from Persea americana Mill. (avocado) leaves

Antiviral Chemistry and Chemotherapy

Volumn 7, Issue 4, 1996, Pages 179-183

  Wigg, M D ^a,b   Al Jabri, A A ^b,d   Costa, S S ^a,c   Race, E ^b   Bodo, B ^a   Oxford, U S ^b  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^d SULTAN QABOOS UNIVERSITY   (Oman)

Author keywords

Antiviral activity; H9 cells; HIV; In vitro; Plant extract

Indexed keywords

ANTIVIRUS AGENT; PLANT EXTRACT;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MEDICINAL PLANT; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL;

EID: 0029955753     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632029600700401     Document Type: Article

References (22)

1. Animashaun, T., Mahmood, Hay, A.J., and Hughes. R.C. (1993) Inhibitory effects of novel mannose-binding lectins on HIV infectivity and syncytium formation. Antiviral Chem Chemother 4: 145-153.
2. Che, C.T. (1991) Plants as a source of potential antiviral agents. In Economics and Medicinal Plant Research, Vol. 5., Wagner, H., and Fansworth, N.R. (eds) London: Academic Press, pp 167-251.
3. Cheng, R.S., and Yeung, H.W. (1988) Inhibition of growth of human immunodeficiency virus in vitro by crude extracts of medicinal herbs. Antiviral Res 9: 163-176.
4. Fitzgibbon, J.E., Howell, R.M., Haberzettl, C.A., Sperber, S.J., Gocke, D.J., and Dubin, D.T. (1992) Human immunodeficiency virus type 1 pol gene mutations which cause decreased susceptibility to 2′,3′-dideoxycytidine. Antimicrob Agents Chemother 36: 153-157.
5. Hu, J.M., and Hsiung, G.D. (1989) Evaluation of new antiviral agents: I- In vitro perspectives. Antiviral Res 11: 217-232.
6. Hudson, J.B. (1990) Antiviral compounds from plants. Boca Raton, Florida CRC Press, Inc., p194.
7. Koseki, I., Simoni, I C., Nakamura, I.T., Noronha, A.B., and Costa, S S. (1990) Antiviral activity of plant extracts against aphtovirus, pseudorabiesvirus and pestivirus in cell cultures. Microbios Letters 44: 19-30.
8. Kreiss, J., Ngugi, E., Holmes, K., Ndinya-Achola, J., Waiyaki, P., Roberts, P.L., Ruminjo, I., Sajabi, R., Kimata, J , Fleming, T R.. Ansala, A., Holton, D., and Plummer, F. (1992) Efficacy of nonoxynol-9 contraceptive sponge in preventing hetero-sexual acquisition of HIV in Nairobi prostitutes JAMA 268: 477-482.
9. Lagrota, M.H.C., Wigg, M.D., Santos, M.G.M., Miranda, M.M.F.S., Camara, P.P., Couceiro, J.N.S.S., and Costa, S.S. (1994) Inhibitory activity of extracts of alternathera Brasiliana (amaranthaceae) against the herpes simplex virus. Phytother Res 8: 358-361.
10. Larder, B., Darby, G., and Richman, D. (1989) HIV with reduced sensitivity to zidovudine isolated during prolonged therapy, Science 243: 1731-1734.
11. Malkovsky, M., Newell, A., and Dalgleish, A.G. (1988) Inactivation of HIV by nonoxynol-9 (letter). Lancet 1: 645.
12. Mead, N A , Staat, R H., Langley, S.D., and Doyle, R.J. (1980) Lectin-like activity from Persea americana. Carbohydr Res 78: 349-363.
13. Mericli, F., Mericli, A.H., Yilmar, F., Yunculler, G., and Yunculler, O. (1992) Flavonoids of avocado (Persea americana). Acta Pharm Turk 34: 61-3.
14. Miranda, M.M.F.S. (1995) Inhibitory effect of Persea americana on acyclovir resistant herpes simplex virus type 1. Master thesis. Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Brazil.
15. Montes, M., Valenzuela, L., and Wilkomirsky, T (1981) Sur la composition de l'essence de Persea americana. Planta Med 42: 306-308.
16. Ono, K., Nakane, H., Fukushima, M., Chermann, J.C., and Barre-Sinoussi, F. (1990) Diferential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. Eur J Biochem 190: 469-476.
17. Oxford, J.S., Zuckerman, M.A., Race, E., Dourmashkin, R., Broadhurst, K., and Sutton, M. (1994) Sodium deoxycholate exerts a direct destructive effect on HIV and influenza viruses in vitro and inhibits retrovirus-induced pathology in an animal model Antiviral Chem Chemother 5: 176-181.
18. Polsky, B., Baron, P.A., Gold, J.W.M., Smith, J.L., Jensen, R.H., and Armstrong, D. (1988) In vitro inactivation of HIV-1 by contraceptive sponge containing nonoxynol-9 (letter). Lancet 1: 1456.
19. Rizzini, C T., and Mors, W.B. (1976) Plantas medicinais. In Britanica Economics Brasileira. Rizzini. C.T. and Mors W B. (eds) Sao Paulo, Brasil: Editora da USPEd, pp71-87
20. Santos, C.A.M., Torres, K.R., and Leonart, R. (1988) Plantas medicinais (herbarium, flora et scientia). 2nd Ed., Icone Ed., P17-21.
21. St Clair, M.H., Martin, J.L., Tudor-Williams, G., Bach. M.C., Vavro, C.L , King, D.M., Kellam, P., Kemp, S.D., and Larder, B.A. (1991) Resistance to ddl and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase. Science 253: 1557-1559.
22. Wigg, M.D. (1991) Interference of plant extracts in the interaction virus-cells: activity of the extract obtained from leaves of Persea americana (avocado tree). PhD thesis. Instituto de Microbiologia. Universidade Federal do Rio de Janeiro, Brazil.