Single intravenous and multiple dose pharmacokinetics of gentamicin in healthy llamas

American Journal of Veterinary Research

Volumn 57, Issue 8, 1996, Pages 1193-1199

  Lackey, Margaret N ^a   Belknap, Ellen B ^a   Greco, Deborah S ^a   Fettman, Martin J ^a  

^a USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENTAMICIN;

ANIMAL EXPERIMENT; ARTICLE; BOVIDS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY FUNCTION; MALE; NONHUMAN; PHARMACOKINETICS;

ANIMALS; ANTI-BACTERIAL AGENTS; CAMELIDS, NEW WORLD; DRUG ADMINISTRATION SCHEDULE; GENTAMICINS; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL;

EID: 0029955692     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Tobin T. Pharmacology review: streptomycin, gentamicin, and the aminoglycoside antibiotics. J Equine Med Surg 1979;3:206-212.
2. Conzelman GM Jr. Pharmacotherapeutics of aminoglycoside antibiotics. J Am Vet Med Assoc 1980;176:1078-1080.
3. McHenry MC, Gavan TL, Gifford RW, et al. Gentamicin dosage for renal insufficiency. Ann Intern Med 1971;74:192-197.
4. Siber GR, Echeverria P, Smith AL, et al. Pharmacokinetics of gentamicin in children and adults. J Infect Dis 1975;132:637-650.
5. Schentag JJ, Cumbo TJ, Jusko WJ, et al. Gentamicin tissue accumulation and nephrotoxic reactions. JAMA 1978;240:2067-2069.
6. Brown SA, Garry FB. Comparison of serum and renal gentamicin concentrations with fractional urinary excretion tests as indicators of nephrotoxicity. J Vet Pharmacol Ther 1988;11:330-337.
7. Garry F, Chew DJ, Hoffsis GF. Urinary indices of renal function in sheep with induced aminoglycoside nephrotoxicosis. Am J Vet Res 1990;51:420-427.
8. Garry F, Chew DJ, Hoffsis GF. Enzymuria as an index of renal damage in sheep with induced aminoglycoside nephrotoxicosis. Am J Vet Res 1990;51:428-432.
9. Greco DS, Turnwald GH, Adams R, et al. Urinary γ-glutamyl transpeptidase activity in dogs with gentamicin-induced nephrotoxicity. Am J Vet Res 1985;46:2332-2335.
10. Dorrestein GM, Van Gogh H, Rinzema JD. Pharmacokinetic aspects of penicillin, aminoglycosides and chloramphenicol in birds compared to mammals: a review. Vet Q 1984;6:216-224.
11. Riviere JE, Coppoc GL. Pharmacokinetics of gentamicin in the juvenile dog. Am J Vet Res 1981;42:1621-1623.
12. Clarke CR, Lochner FK, Bellamy J. Pharmacokinetics of gentamicin and antipyrine in the horse-effect of advancing age. J Vet Pharmacol Ther 1992;15:309-313.
13. Pedersoli WM, Belmonte AA, Purohit RC, et al. Pharmacokinetics of gentamicin in the horse. Am J Vet Res 1980;41:351-354.
14. Haddad NS, Pedersoli WM, Ravis WR, et al. Combined pharmacokinetics of gentamicin in pony mares after a single intravenous and intramuscular administration. Am J Vet Res 1985,46: 2004-2007.
15. Halkin H, Lidji M, Rubenstein E. The influence of endotoxin-induced pyrexia on the pharmacokinetics of gentamicin in the rabbit. J Pharmacol Exp Ther 1981;216:415-418.
16. Bird JE, Miller KW, Larson AA, et al. Pharmacokinetics of gentamicin in birds of prey. Am J Vet Res 1983;44:1245-1247.
17. Jernigan AD, Hatch RC, Wilson RC, et al. Pathologic changes and tissue gentamicin concentrations after intravenous gentamicin administration in clinically normal and endotoxemic cats. Am J Vet Res 1988;49:613-617.
18. Garg SK, Verma SP, Garg BD. Disposition kinetics of gentamicin in buffalo calves (Bubalus bubalis) following single intravenous administration. J Vet Pharmacol Ther 1991;14:335-340.
19. Brown SA, Coppoc GL, Riviere JE. Effects of dose and duration of therapy on gentamicin tissue residues in sheep. Am J Vet Res 1986;47:2373-2579.
20. Haddad NS, Ravis WR, Pedersoli WM, et al. Pharmacokinetics of single doses of gentamicin given by intravenous and intramuscular routes to lactating cows. Am J Vet Res 1986;47:808-813.
21. Riviere JE, Carver MP. Effects of familial hypothyroidism and subtotal surgical nephrectomy on gentamicin pharmacokinetics in Beagle dogs. Chemotherapy 1984,30:216-220.
22. Huang S-M, Huang Y-C, Chiou WL. Triexponential disposition pharmacokinetics of gentamicin in rabbits. Res Commun Chem Pathol Pharmacol 1979;261:115-127.
23. Brown SA, Coppoc GL, Riviere JE, et al. Dose-dependent pharmacokinetics of gentamicin in sheep. Am J Vet Res 1986;47:789-794.
24. Schentag JJ, Jusko WJ. Renal clearance and tissue accumulation of gentamicin. Clin Pharmacol Ther 1977;22:364-370.
25. Kahlmeter G. Nephrotoxicity of gentamicin and tobramycin. Scand J Infect Dis Suppl 1979;11:15-40.
26. Burkhardt JE, Janovitz EB, Bowersock TL, et al. Septicemic Enterococcus infection in an adult llama. J Vet Diagn Invest 1993;5: 106-109.
27. Adams R, Garry FB. Gram-negative bacterial infection in neonatal New World camelids: six cases (1985-1991). J Am Vet Med Assoc 1992;201:1419-1424.
28. Hutchison JM, Belknap EB, Williams RJ. Acute renal failure in the llama (Lama glama). Cornell Vet 1993;83:39-46.
29. Lackey MN, Belknap EB, Salman MD, et al. Urinary indices in llamas fed different diets. Am J Vet Res 1995;56:859-865.
30. Brown SA, Gaird AN. Evaluation of renal gentamicin depletion kinetic properties in sheep, using serial percutaneous biopsies. Am J Vet Res 1988;49:2056-2059.
31. Brown SA, Sugimoto K, Smith GG, et al. Improved sodium hydroxide digestion method without homogenization for extraction of gentamicin from renal tissues. Antimicrob Agents Chemother 1988; 32:595-597.
32. Riviere JE. Veterinary clinical pharmacokinetics. Part II. Modeling. Compend Contin Educ Pract Vet 1988;10:314-328.
33. Brown SA, Riviere JE, Coppoc GL, et al. Single intravenous and multiple intramuscular dose pharmacokinetics and tissue residue profile of gentamicin in sheep. Am J Vet Res 1985;46:69-74.
34. Milton JS, Tsokos JO. Statistical methods in the biological and health sciences. New York: McGraw-Hill Book Co, 1983;423-428.
35. Conover WJ. Practical nonparametric statistics. 2nd ed. New York: John Wiley & Sons, 1980;229-237.
36. Behrend EN, Grauer GF, Greco DS, et al. Effects of dietary protein conditioning on gentamicin pharmacokinetics in dogs. J Vet Pharmacol Ther 1994;17:259-264.
37. Cummings LE, Guthrie AJ, Harkins JD, et al. Pharmacokinetics of gentamicin in newborn to 30-day-old foals. Am J Vet Res 1990;51:1988-1992.
38. Jernigan AD, Wilson RC, Hatch RC, et al. Pharmacokinetics of gentamicin after intravenous, intramuscular, and subcutaneous administration in cats. Am J Vet Res 1988;49:32-35.
39. Wasfi IA, Hadi AAA, Amiri MH, et al. Pharmacokinetics of gentamicin in the camel, in Proceedings. 1st Int Camel Conf 1992; 393-396.
40. Kirkwood JK, Merriam J. Variation in plasma half-life of gentamicin between species in relation to bodyweight and taxonomy. Res Vet Sci 1990;49:160-165.
41. Oukessou M, Toutain PL. Effect of dietary nitrogen intake on gentamicin disposition in sheep. J Vet Pharmacol Ther 1992;15: 416-420.
42. Verpooten GA, Pattyn VM, Giuliano RA, et al. The effect of proteinuria and hyperfiltration on the renal cortical uptake of gentamicin in rats. Kidney Int 1987;31:377.
43. Brown SA, Riviere JE. Comparative pharmacokinetics of aminoglycoside antibiotics. J Vet Pharmacol Ther 1991;14:1-35.
44. Giuliano RA, Verpooten GA, Verbist L, et al. In vivo uptake kinetics of aminoglycosides in the kidney cortex of rats. J Pharmacol Exp Ther 1986;236:470-475.
45. Haddad NS, Ravis WR, Pedersoli WM, et al. Pharmacokinetics and tissue residues of gentamicin in lactating cows after multiple intramuscular doses are administered. Am J Vet Res 1987;48: 21-27.
46. Dahlgren JG, Anderson ET, Hewitt WL. Gentamicin blood levels: a guide to nephrotoxicity. Antimicrob Agents Chemother 1975; 8:58-62.
47. Goran MP, Wright RK, Osborne S. Two automated procedures for N-acetyl-beta-D-glucosaminidase determination evaluated for detection of drug-induced tubular nephrotoxicity. Clin Chem 1986;32:2052-2055.
48. Clarke CR, Short CR, Hsu R-C, et al. Pharmacokinetics of gentamicin in the calf: developmental changes. Am J Vet Res 1985; 46:2461-2466.
49. Finco DR, Coulter DB, Barsanti JA. Simple, accurate method for clinical estimation of glomerular filtration rate in the dog. Am J Vet Res 1981;42:1874-1877.
50. Frazier DL, Aucoin DP, Riviere JE. Gentamicin pharmacokinetics and nephrotoxicity in naturally acquired and experimentally induced disease in dogs. J Am Vet Med Assoc 1988;192:57-63.