Expression of thrombospondin-1 in cancer: A role in tumor progression

Proceedings of the Society for Experimental Biology and Medicine

Volumn 212, Issue 3, 1996, Pages 199-207

  Qian, Xiaohua ^a   Tuszynski, George P ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; THROMBOSPONDIN;

ANIMAL CELL; ANIMAL TISSUE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INVASION; CELL ADHESION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HUMAN TISSUE; METASTASIS; MOUSE; NONHUMAN; PROTEIN INDUCTION; PROTEIN SECRETION; SHORT SURVEY; TUMOR VASCULARIZATION;

ANIMALIA;

EID: 0029955545     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.3181/00379727-212-44008     Document Type: Short Survey

References (96)

1. Baenziger NL, Brodie GN, Majerus PW. Thrombin-sensitive protein of human platelet membranes. Proc Natl Acad Sci USA 68:240-243, 1971.
2. Lawler JW, Slayter HS, Coligan JE. Isolation and characterization of a high molecular weight glycoprotein from human blood platelets. J Biol Chem 253:8609-8616, 1978.
3. Lawler J, Hynes RO. The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins. J Cell Biol 103:1635-1648, 1986.
4. Frazier WA, Dixit VM, Galvin NJ, Rotwein PR. Structure of human thrombospondin: Complete amino acid sequence derived from cDNA. Semin Thromb Hemost 13:255-260, 1987.
5. Frazier WA. Thrombospondins. Curr Opin Cell Biol 3:792-799, 1991.
6. Tuszynski GP, Rothman V, Murphy A, Siegler K, Smith L, Smith S, Karczewski J, Knudsen KA. Thrombospondin promotes cell-substratum adhesion. Science 236:1570-1573, 1987.
7. Varani J, Nickoloff BJ, Riser BL, Mitra RS, ORourke K, Dixit VM. Thrombospondin-induced adhesion of human keratinocytes. J Clin Invest 81:1537-1544, 1988.
8. Morandi V, Fauvel-Lafeve F, Legrand C, Legrand YJ. Role of thrombospondin in the adhesion of human endothelial cells in primary culture. In Vitro Cell Dev Biol 29A:585-591, 1993.
9. Adams JC, Lawler J. Diverse mechanisms for cell attachment to platelet thrombospondin. J Cell Sci 104:1061-1071, 1993.
10. Legrand C, Morandi V, Mendelovitz S, Shaked H, Hartman JR, Panel A. Selective inhibition of platelet macroaggregate formation by a recombinant heparin-binding domain of human thrombospondin. Arterioscler Thromb 14:1784-1791, 1994.
11. Kaesberg PR, Ershler WB, Esko JD, Mosher DF. Chinese hamster ovary cell adhesion to human platelet thrombospondin is dependent on cell surface heparan sulfate proteoglycan. J Clin Invest 83:994-1001, 1989.
12. Asch AS, Silbiger S, Heinegard D, Nachman RL. Thrombospondin sequence motif (CSVTCG) is responsible for CD 36 binding. Biochem Biophys Res Commun 182:1208-1217, 1992.
13. Tuszynski GP, Rothman VL, Papale M, Hamilton BK, Eyal J. Identification and characterization of a tumor cell receptor for CSVTCG, a thrombospondin adhesive domain. J Cell Biol 120:513-521, 1993.
14. Tuszynski GP, Rothman VL, Deutch AH, Hamilton BK, Eyal J. Biological activities of peptides and peptide analogues derived from common sequences present in thrombospondin, properdin, and malarial proteins. J Cell Biol 116:209-217, 1992.
15. Schultz-Cherry S, Chen H, Mosher DF, Misenheimer TM, Krutzsch HC, Roberts DD, Murphy-Ullrich JE. Regulation of transforming growth factor-β activation by discrete sequences of thrombospondin 1. J Biol Chem 270:7304-7310, 1995.
16. 1 as a neuronal thrombospondin receptor mediating neurite outgrowth. Neuron 15:333-343, 1995.
17. Lawler J, Weinstein R, Hynes RO. Cell attachment to thrombospondin: The role of Arg-Gly-Asp, calcium and integrin receptors. J Cell Biol 107:2351-2361, 1988.
18. Gao A-G, Frazier WA. Identification of a receptor candidate for the carboxyl-terminal cell binding domain of thrombospondins. J Biol Chem 269:29650-29657, 1994.
19. Murphy-Ullrich JE, Hook M. Thrombospondin modulates focal adhesions in endothelial cells. J Cell Biol 109:1309-1319, 1989.
20. Adams JC. Formation of stable microspikes containing actin and the 55 kDa actin bundling protein, fascin, is a consequence of cell adhesion to thrombospondin-1: Implications for the anti-adhesive activities of thrombospondin-1. J Cell Sci 108:1977-1990, 1995.
21. Adams J, Lawler J. The thrombospondin family. Curr Biol 3(3): 188-190, 1993.
22. Bornstein P, Sage H. Thrombospondin. Methods Enzymol 245:62-85, 1994.
23. Penttinen RP, Kobayashi S, Bornstein P. Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability. Proc Natl Acad Sci USA 85:1105-1108, 1988.
24. Majack RA, Mildbrandt J, Dixit VM. Induction of thrombospondin messenger RNA levels occurs as an immediate primary response to platelet-derived growth factor. J Biol Chem 262:8821-8825, 1987.
25. Bornstein P. Thrombospondins: Structure and regulation of expression. FASEB J 6:3290-3299, 1992.
26. Qabar A, Derick L, Lawler J, Dixit V. Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues. J Biol Chem 270:12725-12729, 1995.
27. Lawler J, McHenry K, Duquette M, Derick L. Characterization of human thrombospondin-4. J Biol Chem 270:2809-2814, 1995.
28. Morgelin M, Heinegard D, Engel J, Paulsson M. Electron microscopy of native cartilage oligomeric matrix protein purified from the Swarm rat chondrosarcoma reveals a five-armed structure. J Biol Chem 267:6137-6141, 1992.
29. Wight TN, Raugi GJ, Mumby SM, Bornstein P. Light microscopic immunolocation of thrombospondin in human tissues. J Histochem Cytochem 33:295-302, 1985.
30. Lahav J. Distribution of thrombospondin in vivo. In: Lahav J, Ed. Thrombospondin. Boca Raton: CRC Press, p33, 1993.
31. Iruela-Arispe ML, Liska DJ, Sage EH, Bornstein P. Differential expression of thrombospondin 1, 2, and 3 during murine development. Dev Dyn 197:40-56, 1993.
32. Vos HL, Devarayalu S, De Vries Y, Bornstein P. Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family. J Biol Chem 267:12192-12196, 1992.
33. Lawler J, Duquette M, Whittaker CA, Adams JC, McHenry K, DeSimone DW. Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family. J Cell Biol 120:1059-1067, 1993.
34. DiCesare P, Hauser N, Lehman D, Pasumarti S, Paulsson M. Cartilage oligomeric matrix protein (COMP) is an abundant component of tendon. FEBS Lett 354:237-240, 1994.
35. Pellerin S, Lafeuillade B, Wade RH, Savona C, Chambaz EM, Feige J-J. The molecular structure of corticotropin-induced secreted protein, a novel member of the thrombospondin family. J Biol Chem 268:18810-18817, 1993.
36. McPherson J, Sage H, Bornstein P. Isolation and characterization of a glycoprotein secreted by aortic endothelial cells in culture. Apparent identity with platelet thrombospondin. J Biol Chem 256:11330-11336, 1981.
37. Clezardin P. Expression of thrombospondin by cells in culture. In: Lahav J, Ed. Thrombospondin. Boca Raton: CRC Press, p41, 1993.
38. Mumby SM, Abbott Brown D, Raugi GJ, Bornstein P. Regulation of thrombospondin secretion by cells in culture. J Cell Physiol 120:280-288, 1984.
39. Castle VP, Ou X, O'Shea S, Dixit VM. Induction of thrombospondin 1 by retinoic acid is important during differentiation of neuroblastoma cells. J Clin Invest 90:1857-1863, 1992.
40. Liska DJ, Hawkins R, Wikstrom K, Bornstein P. Modulation of thrombospondin expression during differentiation of embryonal carcinoma cells. J Cell Physiol 158:495-505, 1994.
41. McKeown-Longo PJ, Hanning R, Mosher DF. Binding and degradation of platelet thrombospondin by cultured fibroblasts. J Cell Biol 98:22-28, 1984.
42. 2-macroglobulin receptor mediates the cellular internalization and degradation of thrombospondin. A process facilitated by cell-surface proteoglycans. J Biol Chem 270:9543-9549, 1995.
43. Godyna S, Liau G, Popa I, Stefansson S, Argraves WS. Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1. J Cell Biol 129:1403-1410, 1995.
44. Varani J, Riser BL, Hughes LA, Carey TE, Fligiel SE, Dixit VM. Characterization of thrombospondin synthesis, secretion and cell surface expression by human tumor cells. Clin Exp Metastasis 7:265-276, 1989.
45. Clezardin P, Jouishomme H, Chavassieux P, Marie PJ. Thrombospondin is synthesized and secreted by human osteoblasts and osteosarcoma cells. A model to study the different effects of thrombospondin in cell adhesion. Eur J Biochem 181:721-726, 1989.
46. Incardona F, Calvo F, Fauvel-Lafeve F, Legrand Y, Legrand C. Involvement of thrombospondin in the adherence of human breast-adenocarcinoma cells: A possible role in the metastatic process. Int J Cancer 55:471-477, 1993.
47. Beiso P, Pidard D, Fournier D, Dubernard V, Legrand C. Studies on the interaction of platelet glycoprotein IIb-IIIa and glycoprotein IV with fibrinogen and thrombospondin: A new immunochemical approach. Biochim Biophys Acta 1033:7-12, 1990.
48. RayChaudhury A, Frazier WA, D'Amore PA. Comparison of normal and tumorigenic endothelial cells: Differences in thrombospondin production and responses to transforming growth factor-beta. J Cell Sci 107:39-46, 1994.
49. Varani J, Dixit VM, Fligiel SE, McKeever PE, Carey TE. Thrombospondin-induced attachment and spreading of human squamous carcinoma cells. Exp Cell Res 167:376-390, 1986.
50. Castle V, Varani J, Fligiel S, Prochownik EV, Dixit V. Antisense-mediated reduction in thrombospondin reverses the malignant phenotype of a human squamous carcinoma. J Clin Invest 87:1883-1888, 1991.
51. Weinstat-Saslow DL, Zabrenetzky VS, VanHoutte K, Frazier WA, Roberts DD, Steeg PS. Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis. Cancer Res 54:6504-6511, 1994.
52. r 80,000/105,000 receptor. Cancer Res 51:3648-3656, 1991.
53. Pratt DA, Miller WR, Dawes J. Thrombospondin in malignant and non-malignant breast tissue. Eur J Cancer Clin Oncol 25:343-350, 1989.
54. Wong SY, Purdie AT, Han P. Thrombospondin and other possible related matrix proteins in malignant and benign breast disease: An immunohistochemical study. Am J Pathol 140:1473-1482, 1992.
55. Clezardin P, Frappart L, Clerget M, Pechoux C, Delmas PD. Expression of thrombospondin (TSP1) and its receptors (CD36 and CD51) in normal, hyperplastic, and neoplastic human breast. Cancer Res 53:1421-1430, 1993.
56. Tuszynski GP, Nicosia RF. Localization of thrombospondin and its cysteine-serine-valine-threonine-cysteine-glycine-specific receptor in human breast carcinoma. Lab Invest 70:228-233, 1994.
57. Raugi GJ, Olerud JE, Gown AM. Thrombospondin in early human wound tissue. J Invest Dermatol 89:551-554, 1987.
58. O'Shea KS, Dixit VM. Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo. J Cell Biol 107(6):2737-2748, 1988.
59. Arnoletti JP, Albo D, Jhala N, Granick MS, Solomon MP, Atkinson B, Rothman VL, Tuszynski GP. Computer-assisted image analysis of tumor sections for a new thrombospondin receptor. Am J Surg 168:433-436, 1994.
60. Tuszynski GP, Gasic TB, Rothman VL, Knudsen KA, Gasic GJ. Thrombospondin, a potentiator of tumor cell metastasis. Cancer Res 47:4130-4133, 1987.
61. Tuszynski GP, Smith M, Rothman VL, Capuzzi DM, Joseph RR, Katz J, Besa EC, Treat J, Switalska HI. Thrombospondin levels in patients with malignancy. Thromb Haemost 67:607-611, 1992.
62. Nathan FE, Hernandez E, Dunton CJ, Treat J, Switalska HI, Joseph RR, Tuszynski GP. Plasma thrombospondin levels in patients with gynecologic malignancies. Cancer 73:2853-2858, 1994.
63. Incardona F, Lewalle JM, Morandi V, Lambert S, Legrand Y, Foidart JM, Legrand C. Thrombospondin modulates human breast adenocarcinoma cell adhesion to human vascular endothelial cells. Cancer Res 55:166-173, 1995.
64. Gasic GJ, Tuszynski GP, Gorelik E. Interactions of the hemostatic and immune systems in the metastatic spread of tumor cells. Int Rev Exp Pathol 29:173-212, 1986.
65. Tuszynski GP, Rothman VL, Murphy A, Siegler K, Knudsen KA. Thrombospondin promotes platelet aggregation. Blood 72:109-115, 1988.
66. Kehrel B, Balleisen L, Kokott R, Mesters R, Stenzinger W, Clemetson KJ, Van de LJ. Deficiency of intact thrombospondin and membrane glycoprotein Ia in platelets with defective collagen-induced aggregation and spontaneous loss of disorder. Blood 71:1074-1078, 1988.
67. Katagiri Y, Hayashi Y, Baba I, Suzuki H, Tanoue K, Yamazaki H. Characterization of platelet aggregation induced by the human melanoma cell line HMV-1: Roles of heparin, plasma adhesive proteins, and tumor cell membrane proteins. Cancer Res 51:1286-1293, 1991.
68. Clezardin P, Serre C-M, Trzeciak M-C, Drouin J, Delmas PD. Thrombospondin binds to the surface of human osteosarcoma cells and mediates platelet-osteosarcoma cell interaction. Cancer Res 51:2621-2627, 1991.
69. Nicosia RF, Tuszynski GP. Matrix-bound thrombospondin promotes angiogenesis in vitro. J Cell Biol 124:183-193, 1994.
70. Phan SH, Dillon RG, McGarry BM, Dixit VM. Stimulation of fibroblast proliferation by thrombospondin. Biochem Biophys Res Commun 163:56-63, 1989.
71. Majack RA, Cook SC, Bornstein P. Control of smooth muscle cell growth by components of the extracellular matrix: Autocrine role for thrombospondin. Proc Natl Acad Sci USA 83:9050-9054, 1986.
72. Castle VP, Ou X, O'Rourke K, Dixit VM. High level thrombospondin 1 expression in two NIH 3T3 cloned lines confers serum- and anchorage-independent growth. J Biol Chem 268:2899-2903, 1993.
73. Boukerche H, Berthier-Vergnes O, Tabone E, Bailly M, Doré J-F, McGregor JL. Thrombospondin modulates melanoma-platelet interactions and melanoma tumour cell growth in vivo. Br J Cancer 72:108-116, 1995.
74. Taraboletti G, Roberts DD, Liotta LA. Thrombospondin-induced tumor cell migration: Haptotaxis and chemotaxis are mediated by different molecular domains. J Cell Biol 105:2409-2415, 1987.
75. Yabkowitz R, Mansfield PJ, Dixit VM, Suchard SJ. Motility of human carcinoma cells in response to thrombospondin: Relationship to metastatic potential and thrombospondin structural domains. Cancer Res 53:378-387, 1993.
76. Hosokawa T, Muraishi A, Rothman V, Papale M, Tuszynski GP. The effect of thrombospondin on invasion of fibrin gels by human A549 lung carcinoma. Oncol Res 5:183-189, 1993.
77. Albo D, Arnoletti JP, Castiglioni A, Granick MS, Solomon MP, Rothman VL, Tuszynski GP. Thrombospondin (TSP) and transforming growth factor beta 1 (TGF-β) promote human A549 lung carcinoma cell plasminogen activator inhibitor type 1 (PAI-1) production and stimulate tumor cell attachment in vitro. Biochem Biophys Res Commun 203:857-865, 1994.
78. Arnoletti JP, Albo D, Granick MS, Solomon MP, Castiglioni A, Rothman VL, Tuszynski GP. Thrombospondin and transforming growth factor-beta 1 increase expression of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in human MDA-MB-231 breast cancer cells. Cancer 76:998-1005, 1995.
79. Moscatelli D, Rifkin DB. Membrane and matrix localization of proteases: A common theme in tumor cell invasion and angiogenesis. Biochim Biophys Acta 948:67-85, 1988.
80. Wang TN, Qian X, Granick MS, Solomon MP, Rothman VL, Tuszynski GP. The effect of Thrombospondin (TSP) on oral squamous carcinoma cell invasion of collagen. Am J Surg 170:502-505, 1995.
81. Wang TN, Qian X, Rothman VL, Granick MS, Solomon MP, Tuszynski GP. Thrombospondin promotes the invasive properties of human breast cancer. J Surg Res 63: in press, 1996.
82. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med 1:27-31, 1995.
83. Ingber DE. Extracellular matrix as a solid-state regulator in angiogenesis: Identification of new targets for anti-cancer therapy. Semin Cancer Biol 3(2):57-63, 1992.
84. Arbeille BB, Fauvel-Lafeve FMJ, Lemesle MB, Tenza D, Legrand YJ. Thrombospondin: A component of microfibrils in various tissues. J Histochem Cytochem 39:1367-1375, 1991.
85. Good DJ, Polverini PJ, Rastinejad F, Le Beau MM, Lemons RS, Bouck NP. A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc Natl Acad Sci USA 87:6624-6628, 1990.
86. BenEzra D, Griffin BW, Maftzir G, Aharonov O. Thrombospondin and in vivo angiogenesis induced by basic fibroblast growth factor or lipopolysaccharide. Invest Ophthalmol Vis Sci 34:3601-3608, 1993.
87. Taraboletti G, Roberts D, Liotta LA, Giavazzi R. Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: A potential angiogenesis regulatory factor. J Cell Biol 111:765-772, 1990.
88. Tolsma SS, Volpert OV, Good DJ, Frazier WA, Polverini PJ, Bouck N. Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity. J Cell Biol 122:497-511, 1993.
89. Kao KJ, Klein PA. A monoclonal antibody-based enzyme-linked immunosorbent assay for quantitation of plasma thrombospondin. Am J Clin Pathol 86:317, 1986.
90. Switalska HI, Niewiarowski S, Tuszynski GP, Rucinski B, Schmaier AH, Morinelli TA, Cierniewski CS. Radioimmunoassay of human platelet thrombospondin: Different patterns of thrombospondin and beta-thromboglobulin antigen secretion and clearance from the circulation. J Lab Clin Med 106:690-700, 1985.
91. Dawes J, Clemetson KJ, Gogstad GO, McGregor J, Clezardin P, Prowse CV, Pepper DS. A radioimmunoassay for thrombospondin, used in a comparative study of thrombospondin, β-thromboglobulin and platelet factor 4 in healthy volunteers. Thromb Res 29:569, 1983.
92. DiPietro LA, Polverini PJ. Angiogenic macrophages produce the angiogenic inhibitor thrombospondin 1. Am J Pathol 143:678-684, 1993.
93. Canfield AE, Boot-Handford RP, Schor AM. Thrombospondin gene expression by endothelial cell in culture is modulated by cell proliferation, cell shape and the substratum. Biochem J 268:225-230, 1990.
94. Qian X, Nicosia RF, Bochenek KM, Rothman VL, Tuszynski GP. The effect of thrombospondin on endothelial cell tube formation in vitro. Mol Biol Cell 5:179a, 1994.
95. Montesano R, Pepper MS, Mohle-Steinlein U, Risau W, Wagner EF, Orci L. Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene. Cell 62(3):435-445, 1990.
96. Sheibani N, Frazier WA. Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis. Proc Natl Acad Sci USA 92:6788-6792, 1995.