How is expression of the interleukin-5 gene regulated?

Immunology and Cell Biology

Volumn 74, Issue 2, 1996, Pages 218-223

  Karlen, Stéphane ^a   Mordvinov, Viatcheslav A ^a   Sanderson, Colin J ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Gene regulation; Interleukin 5; Signal transduction

Indexed keywords

INTERLEUKIN 5;

ALLERGY; ARTICLE; GENE CONTROL; GENETIC TRANSCRIPTION; HUMAN; IMMUNOMODULATION; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION;

EID: 0029955275     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1038/icb.1996.31     Document Type: Article

References (57)

1. Sanderson CJ. Interleukin-5, eosinophils, and disease. Blood 1992; 79: 3101-9.
2. Corrigan CJ, Kay AB. T cells and eosinophils in the pathogenesis of asthma. Immunology Today 1992; 13: 501-5.
3. Coffman RL, Ohara J, Bond MW, Carty J, Zlotnik E, Paul WE, B-cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated β-cells. J. Immunol. 1986; 136: 4538-41.
4. Coffman RL, Seymur BWP, Lebman DA et al., The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 1988; 102: 5-28.
5. Bohjanen PJ, Okajima M, Hodes RJ. Differential regulation of interleukin 4 and interleukin 5 gene expression: A comparison of T-cell gene induction by anti-CD3 antibody or by exogenous lymphokines. Proc. Natl Acad. Sci. USA 1990; 87: 5283-7.
6. Okudaira H, Mori A, Suko M, Etoh T, Nakagawa H, Ito K. Enhanced production and gene expression of interleukin-5 in patients with bronchial asthma: Possible management of atopic diseases by down-regulation of interleukin-5 gene transcription. Int. Arch. Allergy Immunol. 1995; 107: 255-8.
7. + T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalvcolar lavage after allergen inhalation challenge in patients with atopic asthma. J. Allergy Clin. Immunol. 1993; 92: 313-24.
8. Robinson DS, Ying S, Bentley AM et al. Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma. J. Allergy Clin. Immunol. 1993; 92: 397-403.
9. Warren DJ, Sanderson CJ. Production of a T-cell hybrid producing a lymphokine stimulating eosinophil differentiation. Immunology 1985; 54: 615-23.
10. Naora H, Young IG. Mechanisms regulating the mRNA levels of interleukin-5 and two other coordinately expressed lymphokines in the murine T lymphoma EL4.23. Blood 1994; 83: 3620-8.
11. Crabtree GR. Contingent genetic regulatory events in T lymphocyte activation. Science 1989; 243: 355-61.
12. Masuda ES, Tokumitsu H, Tsuboi A et al. The granulocyte-macrophage colony-stimulating factor promoter cis-acting clement CLE0 mediates induction signals in T cells and is recognised by factors related to AP1 and NFAT. Mol. Cell. Biol. 1993; 13: 7399-407.
13. Naora H, Van Leeuwen BH, Bourke PF, Young IG. Functional role and signal-induced modulation of proteins recognizing the conserved TCATTT-containing promoter elements in the murine IL-5 and GM-CSF genes in T lymphocytes. J. Immunol. 1994; 153: 3466-75.
14. Karlen S, D'Ercole M, Sanderson CJ. Two pathways can activate the interleukin-5 gene and induce binding to the CLE0 clement. Blood (in press).
15. Gruart-Gouilleux V, Engels P, Sullivan M. Characterization of the human interleukin-5 gene promoter: Involvement of octamer binding sites in the gene promoter activity. Eur. J. Immunol. 1995; 25: 1431-5.
16. Yamagata T, Nishida J, Sakai R et al. Of the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5-producing cells which express multiple GATA-binding proteins. Mol. Cell. Biol. 1995; 15: 3830-9.
17. Prieschl EE, Gouilleux-Gruart V, Walker C, Harrer NE, Baumruker T. A nuclear factor of activated T cell-like transcription factor in mast cells is involved in IL-5 gene regulation after IgE plus antigen stimulation. J. Immunol. 1995; 154: 6112-19.
18. Lee HJ, Masuda ES, Arai N, Arai K, Yokota T. Definition of cis-regulatory elements of the mouse interleukin-5 gene promoter. Involvement of nuclear factor of activated T cells-related factors in interleukin-5 expression. J. Biol. Chem. 1995; 270: 17 541-50.
19. Shannon MF, Himes SR, Coles LS. GM-CSF and IL-2 share common control mechanisms in response to costimulatory signals in T cells. J. Leukoc. Biol. 1995; 57: 767-73.
20. Staynov DZ, Cousins DJ, Lee TH. A regulatory element in the promoter of the human granulocyte-macrophage colony-stimulating factor gene that has related sequences in other T-cell-expressed cytokine genes. Proc. Natl Acad. Sci. USA 1995; 92: 3606-10.
21. Rao A. NF-ATp: A transcription factor required for the co-ordinate induction of several cytokine genes. Immunol. Today 1994; 15: 274-81.
22. Henkel G, Brown MA, PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer. Proc. Natl Acad. Sci. USA 1994; 91: 7737-41.
23. Pfeuffer I, Klein-Hessling S, Heinfling A et al. Octamer factors exert a dual effect on the IL-2 and IL-4 promoters. J. Immunol. 1994; 153: 5572-85.
24. Robinson D, Hamid O, Ying S et al. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression. An. Rev. Respir. Dis. 1993; 148: 401-6.
25. Mori A, Suko M, Nishizaki Y et al. Regulation of interleukin-5 production by peripheral blood mononuclear cells from atopic patients with FK506, cyclosporin A and glucocorticoid. Int. Arch. Allergy Immunol. 1994; 104 Suppl. 1: 32-5.
26. Okayama H, Fushimi T, Shimura S, Sasaki H, Shirato K. Glucocorticoids suppressed production and gene expression of interleukin-5 by peripheral blood mononuclear cells in atopic patients and normal subjects. J. Allergy Clin. Immunol. 1994; 93: 1006-12.
27. Rolfe HG, Hughes JM, Armour CL, Sewell WA. Inhibition of interleukin-5 gene expression by dexamethasone. Immunology 1992; 77: 494-9.
28. Taniguchi T. Regulation of cytokine gene expression. Ann. Rev. Immunol. 1988; 6: 439-64.
29. Jonat C, Rahmsdorf HJ, Park KK et al. Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 1990; 62: 1189-204.
30. Adcock IM, Brown CR, Shirasaki H, Barnes PJ. Effects of dexamethasone on cytokine and phorbol ester stimulated c-Fos and c-Jun DNA binding and gene expression in human lung. Eur. Respir. J. 1994; 7: 2117-23.
31. Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin AS Jr. Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Mol. Cell. Biol. 1995; 15: 943-53.
32. Paliogianni F, Raptis A, Ahuja SS, Najjar SM, Boumpas DT. Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT. J. Clin. Invest. 1993; 91: 1481-9.
33. Schreiber SL, Crabtree GR. The mechanism of action of cyclosporin A and FK506. Immunology Today 1992; 13: 136-42.
34. Andersson J, Nagy S, Groth C-J, Andersson U. Effects of FK506 and cyclosporin A on cytokine production studied in vitro at a single-cell level. Immunology 1992; 75: 136-42.
35. McCaffrey PG, Luo C, Kerppola TK et al. Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science 1993; 262: 750-4.
36. Konno S, Adachi M, Asano K, Okamoto K, Takahashi T. Anti-allergic activity of roxitromycin: inhibition of interleukin-5 production from mouse T lymphocytes. Life Sci. 1993; 52: 25-30.
37. Konno S, Asano K, Kurokawa M, Ikeda K, Okamoto K, Adachi M. Antiasthmatic activity of a macrolide antibiotic, roxithromycin: analysis of possible mehanisms in vitro and in vivo. Int. Arch. Allergy Immunol. 1994; 105: 308-16.
38. Lai JH, Tan TH. CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin. J. Biol. Chem. 1994; 269: 30 077-80.
39. Perlmutter RM, Levin SD, Appleby MW, Anderson SJ, Alberola-Ila J. Regulation of lymphocyte function by protein phosphorylation. Ann. Rev. Immunol. 1993; 11: 451-99.
40. Rincon M, Flavell RA. AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes. EMBO J. 1994; 13: 4370-81.
41. Jenkins MK, Johnson JG. Molecules involved in T-cell costimulation. Current Opin. Immunol. 1993; 5: 361-7.
42. Schandene L, Alonso-Vega C, Willems F et al. B7/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10. J. Immunol. 1994; 152: 4368-74.
43. Wierenga EA, Snoek M, Jansen HM, Bos JD, van Lier RAW, Kapsenberg ML. Human atopen-specific types 1 and 2 T helper cell clones. J. Immunol. 1991; 147: 2942-9.
44. Kuiper HM, de Jong R, Brouwer M, Lammers K, Wijdenes J, van Lier RAW. Influence of CD28 co-stimulation on cytokinc production is mainly regulated via interleukin-2. Immunology 1994; 83: 38-44.
45. Lee HJ, Koyano-Nakagawa N, Naito Y et al. cAMP activates the IL-5 promoter synergistically with phorbol ester through the signaling pathway involving protein kinase A in mouse thymoma line EL-4. J. Immunol. 1993; 151: 6135-42.
46. Schwaninger M, Blume R, Kruger M, Lux G, Oetjen E, Knepel W. Involvement of the C(2 +)-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements. J. Biol. Chem. 1995; 270: 8860-6.
47. Lee HJ, Koyano-Nakagawa N, Naito Y et al. cAMP activates the IL-5 promoter synergistically with phorbol ester through the signaling pathway involving protein kinase A in mouse thymoma line EL-4. J. Immunol. 1993; 151: 6135-42.
48. Chen D, Rothenberg EV. Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles. J. Exp. Med. 1994; 179: 931-42.
49. Derig HG, Burgess GS, Klinberg D et al. Role for cyclic AMP in the postreceptor control of cytokine stimulated stromal cell growth factor production. Leukemia 1990; 4: 471-9.
50. Novak TJ, Rothenberg EV. cAMP inhibits induction of interleukin-2 but not of interleukin-4 in T-cells. Proc. Natl Acad. Sci. USA 1990; 87: 9353-7.
51. Schmidt J, Fleissner S, Heimann-Weitschat I, Lindstaedt R, Szelenyi I. Histamine increases anti-CD3 induced IL-5 production of T-type T cells via histamine H2-receptors. Agents Actions 1994; 42: 81-5.
52. de Groot RP, Auwerx J, Karperien M, Staels B, Krujier W. Activation of junB by PKC and PKA signal transduction through a novel cis-acting element. Nucleic Acids Res. 1991; 19: 775-81.
53. Fraser JD, Straus D, Weiss A. Signal transduction events leading to T-cell lymphokine gene expression. Immunol. Today 1993; 14: 357-62.
54. Miyazaki T, Liu Z-J, Kawahara A et al. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 1995; 81: 223-231.
55. Hsu J-C, Cressman DE, Raub R. Promoter-specific trans-activation and inhibition mediated by JunB. Cancer Res. 1993; 53: 3789-94.
56. Chiu R, Angel P, Karin M. Jun-B differs in its biological properties from and is a negative regulator of, c-Jun. Cell 1989; 59: 979-86.
57. Kobierski LA, Chu H-M, Tan Y, Comb MJ. cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins. Proc. Natl Acad. Sci. USA 1991; 88: 10222-6.