Human TH1 and TH2 cells: Functional properties, mechanisms of development and role in diseases

Allergologie

Volumn 19, Issue 4, 1996, Pages 175-179

  Romagnani, S ^a,b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b NONE   (Germany)

Author keywords

CD30; helper cells; LAG 3; TH1 cells; TH2 cells

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; LYMPHOTOXIN;

AUTOIMMUNITY; BACTERIAL INFECTION; CELL DIFFERENTIATION; CELL FUNCTION; GENE EXPRESSION; GRAFT REJECTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; SHORT SURVEY; T LYMPHOCYTE; WORM INFECTION;

EID: 0029954780     PISSN: 03445062     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (18)

1. Chilosi M., F. Facchetti, L.D. Notarangelo, S Romagnani, G.F. Del Prete, F. Almerigogna, M. De Carli, G. Pizzolo: CD30 cell expression and abnormal soluble CD30 serum accumulation in Omenn's syndrome. Evidence for a Th2-mediated condition. Eur. J. Immunol. in press (1995).
2. Clerici M., G Shearer: A Th1/Th2 switch is a critical step in the etiology of HIV infection. Immunol. Today 14, 107-111 (1993).
3. + T cells producing Th2-type cytokines. FASEB J. 9, 81-86 (1995).
4. Del Prete G F., M, De Carli, M.M. D'Elios, K.C. Daniel, C.A. Smith, E. Thomas, S. Romagnani: CD30-mediated signalling promotes the development of human Th2-like T cells. J. Exp. Med 182, 1-7 (1995)
5. Maggi E , M Mazzetti, A. Ravina, R. Manetti, M. De Carli, F. Annunziato, M.-P Piccinni, A.M Carbonari, G.F. Pesce, G.F. Del Prete, S. Romagnani: Ability of HIV-1 to promote a Th1 to Th0 shift and to replicate preferentially in Th2 and Th0 cells. Science 265, 244-247 (1994).
6. + cells from HIV-infected individuals. Immunity 3, 1-5 (1995).
7. + T cell clones in human immunodeficiency virus infection. J. Exp. Med. 180, 2407-2411 (1994).
8. McDonald P., M. Cassatella, A. Bald, E. Maggi, S Romagnani, H.-J. Gruss, G. Pizzolo: CD30 ligation induces nuclear factor-B activation in human T cell lines Eur. J. Immunol. 25, 2870-2876 (1995).
9. Mosmann T.R., R.L. Coffman: Th1 and Th2 cells. Different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145-173 (1989).
10. Paul W E., R A Seder: Lymphocyte responses and cytokines. Cell 76, 241-251 (1994).
11. Piccinni M.-P., M.G. Giudizi, R. Biagiotti, L. Beloni, L. Giannarini, S. Sampognaro, P. Parronchi, R. Manetti, F. Annunziato, C. Livi, S. Romagnani, E. Maggi: Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J. Immunol. 155, 128-133 (1995).
12. Pizzolo G., F. Vinante, L. Morosato, G. Nadali, M. Chilosi, G. Gandini, A. Sinicco, S. Raiteri, G. Semenzato, H. Stein, G. Perona: High serum levels of soluble form of CD30 molecule in the early phase of HIV-1 infection as an independent predictor of progression to AIDS. AIDS 8, 793-797 (1994).
13. Romagnani S.: Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 12, 227-257 (1994a).
14. Romagnani S.: Regulation of Th2 development in allergy. Curr. Opin. Immunol. 6: 838-846 (1994b).
15. Romagnani S., Human Th1 and Th2 subsets. "Eppur si muove". Eur. Cytokine Netw. 5, 7-12 (1994c).
16. Smith C.A., H.-J. Gruss, T. Davis, D. Anderson, T. Farrah, E. Baker, G.R. Sutherland, C.I. Brannan, N.G. Copeland, N.A. Jenkins, K.H. Grabstein, B. Gliniak, I.B. McAllister, W. Fanslow, M. Alderson, B. Falk, S. Gimpel, S. Gillis, W.S. Din, R. Goodwin, R.J. Armitage: CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell 73, 1349-1360 (1993).
17. Triebel F., S. Jitsukawa, E. Baixeras, S. Roman-Roman, C. Genevee, E. Viegas-Pequignot, T. Hercend: LAG-3, a novel lymphocyte activation gene closely related to CD4. J. Exp. Med. 171, 1393-1405 (1990).
18. Annunziato F. et al.: Expression and release of LAG-3-associated protein by human CD4+ T cells are associated with IFN-γ production. FASEB J. (in press).