Development of a canine multidrug chemotherapeutic model using doxorubicin, cisplatin, and ifosfamide

Journal of Experimental and Clinical Cancer Research

Volumn 15, Issue 3, 1996, Pages 277-281

  Ikeda, K ^a   Waltrip, R L ^b   Inoue, N ^a   Frassica, F J ^a   Chao, E Y S ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Canine model; Chemotherapy; Cisplatin; Doxorubicin; Ifosfamide

Indexed keywords

CISPLATIN; DOXORUBICIN; IFOSFAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CELL COUNT; CANCER CHEMOTHERAPY; COMBINATION CHEMOTHERAPY; DOG; MALE; NONHUMAN; PRIORITY JOURNAL;

EID: 0029954525     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Eiber F.R., Morton D.L., Eckardt J., Grant T., Weisenburger T.: Limb salvage for skeletal and soft tissue sarcomas. Multidisciplinary preoperative therapy. Cancer 53: 2579-2584, 1984.
2. Berrey B.J., Lord C.F., Gebhardt M.C., Mankin H.J.: Fractures of allografts. Frequency, treatment, and end-results. J. Bone Joint Surg. 72-A: 825-833, 1990.
3. Simon M.A.: Limb salvage for osteosarcoma. J. Bone Joint Surg. 70-A: 307-310, 1988.
4. Quill G., Gitelis S., Morton T., Piasecki P.: Complications associated with limb salvage for extremity sarcomas and their management. Clin. Orthop. Res. 260: 242-250, 1990.
5. Ruggiere P., De Cristofaro R., Picci P.: Complications and surgical indications in 144 cases of nonmetastatic osteosarcoma of the extremities treated with neoadjuvant chemotherapy. Clin. Orthop. Res. 295: 226-238, 1993.
6. McDonald D.J., Capanna R., Gherlinzoni F.: Influence of chemotherapy on perioperative complications in limb salvage surgery for bone tumors. Cancer 65: 1509-1516, 1990.
7. Nelson T.E., Ruggieri P., Rock M.G., Sim F.H.: Early results and complications of neoadjuvant chemotherapy in osteosarcoma of the extremities. In ISOLS, 7th symposium. Singapore 345, 1993.
8. Devereux D.F., Thibault L., Boretos J., Brennan M.F.: The quantitative and qualitative impairment of wound healing by adriamycin. Cancer 43: 932-937, 1979.
9. Cohen S.C., Gabelnick H.L., Johnson R.K., Goldin A.: Effects of cyclophosphamide and adriamycin on the healing of surgical wounds in mice. Cancer 36: 1277-1281, 1975.
10. Cohen S.C., Gabelnick H.L., Johnson R.K., Goldin A.: Effects of antineoplastic agents on wound healing in mice. Surgery 78: 238-244, 1975.
11. _Sommer-Tsilenis E., Sauer H.D., Kruse H.P.: Delaying effect of cyclosphamide on bone fracture healing: chemical analyses of rat femore. Arch. Orthop. Trauma Surg. 101: 89-93, 1983.
12. Stanisavljevic S., Babcock A.L.: Fractures in children treated with methotrexate for leukemia. Clin. Orthop. Res. 125: 139-144, 1977.
13. Khoo D.B.A.: The effect of chemotherapy on soft tissue and bone healing in the rabbit modell. Ann. Acad. Med. 21: 217-221, 1992.
14. Friedlaender G.E., Tross R.B., Doganis A.C., Kirkwood J.M., Baron R.: Effects of chemotherapeutic agents on bone: short-term methotrexate and doxorubicin treatment in a rat model. J. Bone Joint Surg. 66-A: 602-607, 1984.
15. May K.P., West S.G., McDermott M.T., Huffer W.E.: The effect of low-dose methotrexate on bone metabolism and histomorphometry in rats. Arthritis Rheum. 37: 201-206, 1994.
16. Burchardt H., Glowczewskie F.P., Enneking W.F.: The effect of adriamycin and methotrexate on the repair of segmental corcial autografts in dogs. J. Bone Joint Surg. 65-A: 103-108, 1983.
17. Epelman S., Seibel N., Melaragno R.: Treatment of newly diagnosed high grade osteosarcoma with ifosfamide, adriamycin, and cisplatin without high dose methotrexate. In: Perry M.C., ed. Proceedings of ASCO. Los Angeles, CA: W.B. Saunders, pp. 439, 1995.
18. Johnson T., Gian V., Lynch J.: Dose intensive neoadjuvant chemotherapy with ifosfamide/mesna, doxorubicin, and cisplatin achieves good histologic response in adult patients with osteosarcoma. In Proceedings of ASCO; Dallas TX: W.B. Saunders pp. 478, 1994.
19. Madewell B.R., Leighton R.L., Theilen G.H.: Amputation and doxorubicin for treatment of canine and feline osteogenic sarcoma. Europ J. Cancer 14: 278-293, 1978.
20. Withrow S.J., Thrall D.E., Staw R.C., Powers B.E., Wrigley R.H., Larue S.M., Page R.L., Richardson D.C., Bissonette K.W., Betts C.W., DeYoung D.J., Ritcher S.L., Jameson V.J., George S.L., Dodge R., Gillette E.L., Douple E.B.: Intra-arterial cisplatin with or without radiation in limb-sparing for canine osteosarcoma. Cancer 71: 2484-2490, 1993.
21. Young D.R., Shih L.Y., Sim F.H., Rock M.G., Frassica F.J., Chao E.Y.S.: Effects of perioperative cisplatin chemotherapy on biologic fixation of a model limb salvage prosthesis. Tran saction of ORS meeting 19: 250, 1994.
22. Zart D.J., Miya L., Wolff D.A., Makley J.T., Stevenson S.: The effects of cisplatin on the incorporation of fresh syngeneic and frozen allogeneic cortical bone grafts. J. Orthop. Res. 11:240-249, 1993.
23. Faldson G., Van Dyk J., Stapelberg R., Faldson H.C.: Mesnum as a protector against kidney and bladder toxicity with high-dose ifosfamide treatment. Cancer Chemother. Pharmacol. 9: 81-84, 1982.