Properties of spontaneous inhibitory synaptic currents in cultured rat spinal cord and medullary neurons

Journal of Neurophysiology

Volumn 76, Issue 1, 1996, Pages 448-460

  Lewis, C A ^a   Faber, D S ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 AMINOBUTYRIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ADENOSINE TRIPHOSPHATE; BICUCULLINE; GLYCINE; GUANOSINE TRIPHOSPHATE; NEUROTRANSMITTER; POSTSYNAPTIC RECEPTOR; STRYCHNINE; TETRODOTOXIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FETUS; INHIBITORY POSTSYNAPTIC POTENTIAL; MEDULLA OBLONGATA; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SPINAL CORD NERVE CELL; SYNAPTIC TRANSMISSION;

EID: 0029954378     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1996.76.1.448     Document Type: Article

References (56)

1. AHMED, A. AND FELLOWS, R. E. Determination of the birth date and proliferative state of dissociated cells from fetal rat brain. Dev. Brain Res. 37: 77-87, 1987.
2. AKAIKE, N., HARATA, N., UENO, S., AND TATEISHI, N. GABAergic synaptic current in dissociated nucleus basalis of Meynert neurons of the rat. Brain Res. 570: 102-108, 1992.
3. ANKRI, N., LEGENDRE, P., FABER, D. S., AND KORN, H. Automatic detection of spontaneous synaptic responses in central neurons. J. Neurosci. Methods 52: 87-100, 1994.
4. BECKER, C.-M., BETZ, H., AND SCHRODER, H. Expression of inhibitory glycine receptors in postnatal rat cerebral cortex. Brain Res. 606: 220-226, 1993.
5. BECKER, C.-M., HOCH, W., AND BETZ, H. Glycine receptor heterogeneity in rat spinal cord during postnatal development. EMBO J. 7: 3717-3726, 1988.
6. BEKKERS, J. M. AND STEVENS, C. F. NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus. Nature Lond. 341: 230-233, 1989.
7. A-receptors at GABAergic synaptic contacts demonstrated by triple immunofluorescence staining. Brain Res. 642: 59-69, 1994.
8. BORST, J. G. G., LODDER, J. C., AND KITS, K. S. Large amplitude variability of GABAergic IPSCs in melanotropes from Xenopus laevis: evidence that quantal size differs between synapses. J. Neurophysiol. 71: 639-655, 1994.
9. CELEUX, G. AND DIEBOLD, J. The SEM algorithm: a probabilistic teacher algorithm derived from the EM algorithm for the mixture problem. Comput. Stat. Q. 2: 73-82, 1985.
10. COLLINGRIDGE, G. L., GAGE, P. W., AND ROBERTSON, B. Inhibitory postsynaptic currents in rat hippocampal CA1 neurons. J. Physiol. Lond. 356: 551-564, 1984.
11. A receptor channels. J. Neurophysiol. 71: 1318-1335, 1994.
12. DIEUDONNE, S. Glycinergic synaptic currents in Golgi cells of the rat cerebellum. Proc. Natl. Acad. Sci. USA 92: 1441-1445, 1995.
13. EDMONDS, B., GIBB, A. J., AND COLQUHOUN, D. Mechanisms of activation of glutamate receptors and the time course of excitatory synaptic currents. Annu. Rev. Physiol. 57: 495-519, 1995.
14. EDWARDS, F. A., KONNERTH, A., AND SAKMANN, B. Quantal analysis of inhibitory synaptic transmission in the dentate gyrus of rat hippocampal slices; a patch-clamp study. J. Physiol. Lond. 430: 213-249, 1990.
15. FABER, D. S. AND KORN, H. Unitary conductances changes at teleost Mauthner cell glycinergic synapses: a voltage-clamp and pharmacologic analysis. J. Neurophysiol. 60: 1982-1999, 1988.
16. FABER, D. S., YOUNG, W. S., LEGENDRE, P., AND KORN, H. Intrinsic quantal variability due to stochastic properties of receptor-transmitter interactions. Science Wash. DC 258: 1494-1498, 1992.
17. FATIMA-SHAD, K. AND BARRY, P. H. A patch-clamp study of GABA-and strychnine-sensitive glycine-activated current in post-natal tissue-cultured hippocampal neurons. Proc. R. Soc. Lond. B Biol. Sci. 250: 99-105, 1992.
18. GLEASON, E., BORGES, S., AND WILSON, M. Synaptic transmission between pairs of retinal amacrine cells in culture. J. Neurosci. 13: 2359-2370, 1993.
19. GOLD, M. R. AND MARTIN, A. R. Characteristics of inhibitory post-synaptic currents in brain-stem neurones of the lamprey. J. Physiol. Lond. 342: 85-98, 1983.
20. A receptor function during whole-cell recording: a possible role for phosphorylation. Mol. Pharmacol. 34: 719-723, 1988.
21. HAMILL, P. P., MARTY, A., NEHER, E., SAKMANN, B., AND SIGWORTH, F. J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pfluegers Arch. 391: 85-100, 1981.
22. A-mediated synaptic events in rat hippocampal CA3 neurons. Eur. J. Neurosci. 6: 805-813, 1994.
23. KORN, H., BAUSELA, F., CHARPIER, S., AND FABER, D. S. Synaptic noise and multiquantal release at dendritic synapses. J. Neurophysiol. 70: 1249-1254, 1993.
24. KORN, H., BURNOD, Y., AND FABER, D. S. Spontaneous quantal currents in a central neuron match predictions from binomial analysis of evoked responses. Proc. Natl. Acad. Sci. USA 84: 5981-5985, 1987.
25. KORN, H. AND FABER, D. S. Transmission at a central inhibitory synapse. IV. Quantal structure of synaptic noise. J. Neurophysiol. 63: 198-222, 1990.
26. KRASZEWSKI, K. AND GRANTYN, R. Unitary, quantal and miniature GABA-activated synaptic chloride currents in cultured neurons from the rat superior colliculus. Neuroscience 47: 555-570, 1992.
27. A receptor function by protein kinase C phosphorylation. Neuron 12: 1081-1095, 1994.
28. LEGENDRE, P. AND KORN, H. Glycinergic inhibitory synaptic currents and related receptor channels in the zebrafish brain. Eur. J. Neurosci. 6: 1544-1557, 1994.
29. LEWIS, C. A. AND FABER, D. S. GABA responses and their partial occlusion by glycine in cultured rat medullary neurons. Neuroscience 52: 83-96, 1993.
30. LEWIS, C. A. AND FABER, D. S. Inhibitory synaptic transmission in isolated patches of membrane from cultured rat spinal cord and medullary neurons. J. Neurophysiol. 76: 461-470, 1996.
31. LLANO, I., LERESCHE, N., AND MARTY, A. Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currents. Neuron 6: 565-574, 1991.
32. MALOSIO, M.-L., MARQUEZE-POUEY, B., KUHSE, J., AND BETZ, H. Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain. EMBO J. 10: 2401-2409, 1991.
33. MCBAIN, C. J. AND MAYER, M. L. N-methyl-D-aspartic acid receptor structure and function. Physiol. Rev. 74: 723-760, 1994.
34. ORNUNG, G., SHUPLIAKOV, O., OTTERSEN, O. P., STORM-MATHISEN, J., AND CULLHEIM, S. Immunohistochemical evidence for coexistence of glycine and GABA in nerve terminals on cat spinal motoneurones: an ultrastructural study. Neuroreport 5: 889-892, 1994.
35. OTIS, T. S., STALEY, K. J., AND MODY, I. Perpetual inhibitory activity in mammalian brain slices generated by spontaneous GABA release. Brain Res. 545: 142-150, 1991.
36. A responses in rat hippocampus. Neuron 10: 189-200, 1993.
37. - currents in Purkinje versus granule neurons in rat cerebellar slices. Neuron 12: 117-126, 1994.
38. RANDLE, J. C. R., BOURQUE, C. W., AND RENAUD, L. P. Characterization of spontaneous and evoked inhibitory postsynaptic potentials in rat supraoptic neurosecretory neurons in vitro. J. Neurophysiol. 56: 1703-1707, 1986.
39. ROPERT, N., MILES, R., AND KORN, H. Characteristics of miniature inhibitory postsynaptic currents in CA1 pyramidal neurones of rat hippocampus. J. Physiol. Lond. 428: 707-722, 1990.
40. 2 subunit mRNA in the rat brain. Brain Res. 590: 95-108, 1992.
41. SCHNEGGENBURGER, R. AND KONNERTH, A. GABA-mediated synaptic transmission in neuroendocrine cells: a patch-clamp study in a pituitary slice preparation. Pfluegers Arch. 421: 364-373, 1992.
42. A receptor by intracellular ATP in dissociated nucleus tractus solitarii neurones of rat. J. Physiol. Lond. 449: 551-572, 1992.
43. SIEBLER, M., PEKEL, M., KOLLER, H., AND MULLER, H.-W. Strychnine-sensitive glycine receptors in cultured primary neurons from rat neocortex. Dev. Brain Res. 73: 289-292, 1993.
44. A-receptor function in hippocampal cells is maintained by phosphorylation factors. Science Wash. DC 241: 339-341, 1988.
45. TAKAHASHI, T. The minimal inhibitory synaptic currents evoked in neonatal rat motoneurones. J. Physiol. Lond. 450: 593-611, 1992.
46. TAKAHASHI, T., MOMIYAMA, A., HIRAI, K., HISHINUMA, F., AND AKAGI, H. Functional correlation of fetal and adult forms of glycine receptors with developmental changes in inhibitory synaptic receptor channels. Neuron 9: 1155-1161, 1992.
47. TAKAHASHI, Y., SHIRASAKI, T., YAMANAKA, H., ISHIBASHI, H., AND AKAIKE, N. Physiological roles of glycine and γ-aminobutyric acid in dissociated neurons of rat visual cortex. Brain Res. 640: 229-235, 1994.
48. TRILLER, A., SUR, C., AND KORN, H. Heterogeneous distribution of glycinergic and GABAergic afferents on an identified central neuron. J. Comp. Neurol. 338: 83-96, 1993.
49. TROMBLEY, P. Q. AND SHEPHERD, G. M. Glycine exerts potent inhibitory actions on mammalian olfactory bulb neurons. J. Neurophysiol. 71: 761-767, 1994.
50. ULRICH, D. AND LUSCHER, H.-R. Miniature excitatory synaptic currents corrected for dendritic cable properties reveal quantal size and variance. J. Neurophysiol. 69: 1769-1773, 1993.
51. VAELLO, M.-L., RUIZ-GOMEZ, A., LERMA, J., AND MAYOR, F., JR. Modulation of inhibitory glycine receptors by phosphorylation by protein kinase C and cAMP-dependent protein kinase. J. Biol. Chem. 269: 2002-2008, 1994.
52. WALAAS, S. I. AND GREENGARD, P. Protein phosphorylation and neuronal function. Pharmacol. Rev. 43: 299-349, 1991.
53. WENTZEL, P. R., DE ZEEUW, D. I., HOLSTEGE, J. C., AND GERRITS, N. M. Colocalization of GABA and glycine in the rabbit oculomotor nucleus. Neurosci. Lett. 164: 25-29, 1993.
54. WILKS, S. S. The large sample distribution of the likelihood ratio for testing composite hypotheses. Ann. Meth. Stat. 9: 60-62, 1938.
55. WOLFE, J. H. A Monte Carlo study of the sampling distribution of the likelihood ratio for mixtures of multinomial distributions. Naval Personnel and Training Research Laboratory Technical Bulletin S. T. B. 72-2, 1972.
56. WUARIN, J.-P. AND DUDEK, F. E. Patch-clamp analysis of spontaneous synaptic currents in supraoptic neuroendocrine cells of the rat hypothalamus. J. Neurosci. 13: 2323-2331, 1993.