Regioselectivity and substrate concentration-dependency of involvement of the CYP2D subfamily in oxidative metabolism of amitriptyline and nortriptyline in rat liver microsomes

Journal of Pharmacy and Pharmacology

Volumn 48, Issue 9, 1996, Pages 925-929

  Masubuchi, Yasuhiro ^a   Iwasa, Takashi ^a   Fujita, Shoichi ^b   Suzuki, Tokuji ^a   Horie, Toshiharu ^a   Narimatsu, Shizuo ^a  

^a CHIBA UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; CYTOCHROME P450 ISOENZYME; IMIPRAMINE; N DEMETHYLASE; NORTRIPTYLINE; SPARTEINE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG OXIDATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; LIVER MICROSOME; MALE; NONHUMAN; RAT; SEX DIFFERENCE; STEREOCHEMISTRY; STRAIN DIFFERENCE;

EID: 0029954127     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1996.tb06003.x     Document Type: Article

References (10)

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