-
1
-
-
0027328976
-
The effect of fluorine substitution on the hepatotoxity and metabolism of paracetamol in the mouse
-
BARNARD, S., KELLY, D. F., STORR, R. C., and PARK, B. K., 1993a, The effect of fluorine substitution on the hepatotoxity and metabolism of paracetamol in the mouse. Biochemical Pharmacology, 46, 841-849.
-
(1993)
Biochemical Pharmacology
, vol.46
, pp. 841-849
-
-
Barnard, S.1
Kelly, D.F.2
Storr, R.C.3
Park, B.K.4
-
2
-
-
0027305369
-
The effect of fluorine substitution on the physicochemical properties and the analgesic activity of paracetamol
-
BARNARD, S., STORR, R. C., O'NEILL, P. M., and PARK, B. K., 1993b, The effect of fluorine substitution on the physicochemical properties and the analgesic activity of paracetamol. Journal of Pharmacy and Pharmacology, 45, 736-744.
-
(1993)
Journal of Pharmacy and Pharmacology
, vol.45
, pp. 736-744
-
-
Barnard, S.1
Storr, R.C.2
O'Neill, P.M.3
Park, B.K.4
-
3
-
-
0029417077
-
3,5-Disubstituted analogues of paracetamol. Synthesis, analgesic activity and cytotoxicity
-
BESSEMS, J. G. M., GAISSER, H.-D., TE KOPPELE, J. M., VAN BENNEKOM, W. P., COMMANDEUR, J. N. M., and VERMEULEN, N. P. E., 1995, 3,5-Disubstituted analogues of paracetamol. Synthesis, analgesic activity and cytotoxicity. Chemico-Biological Interactions, 98, 237-250.
-
(1995)
Chemico-Biological Interactions
, vol.98
, pp. 237-250
-
-
Bessems, J.G.M.1
Gaisser, H.-D.2
Te Koppele, J.M.3
Van Bennekom, W.P.4
Commandeur, J.N.M.5
Vermeulen, N.P.E.6
-
4
-
-
0019203064
-
Paracetamol oxidation: Synthesis and reactivity of N-acetyl-p-benzoquinoneimine
-
BLAIR, I. A., BOOBIS, A. R., and DAVIES, D. S., 1980, Paracetamol oxidation: synthesis and reactivity of N-acetyl-p-benzoquinoneimine. Tetrahedron Letters, 21, 4947-4950.
-
(1980)
Tetrahedron Letters
, vol.21
, pp. 4947-4950
-
-
Blair, I.A.1
Boobis, A.R.2
Davies, D.S.3
-
5
-
-
0027475989
-
Determinants of protein modification versus heme alkylation - Inactivation of cytochrome-P450 1A1 by 1-ethynylpyrene and phenylacetylene
-
CHAN, W. K., SUI, Z., and ORTIZ DE MONTELLANO, P. R., 1993, Determinants of protein modification versus heme alkylation - inactivation of cytochrome-P450 1A1 by 1-ethynylpyrene and phenylacetylene. Chemical Research in Toxicology, 6, 38-45.
-
(1993)
Chemical Research in Toxicology
, vol.6
, pp. 38-45
-
-
Chan, W.K.1
Sui, Z.2
Ortiz De Montellano, P.R.3
-
6
-
-
0020034744
-
Paracetamol-induced acute renal failure in the absence of fulminant liver damage
-
COBDEN, I., RECORD, C. O., WARD, M. K., and KERR, B. N. S., 1982, Paracetamol-induced acute renal failure in the absence of fulminant liver damage. British Medical Journal, 284, 21-22.
-
(1982)
British Medical Journal
, vol.284
, pp. 21-22
-
-
Cobden, I.1
Record, C.O.2
Ward, M.K.3
Kerr, B.N.S.4
-
7
-
-
0020427899
-
Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen
-
DAHLIN, D. C., and NELSON, S. D., 1982, Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen. Journal of Medicinal Chemistry, 25, 885-886.
-
(1982)
Journal of Medicinal Chemistry
, vol.25
, pp. 885-886
-
-
Dahlin, D.C.1
Nelson, S.D.2
-
8
-
-
0021345926
-
N-acetyl-p-benzoquinone imine: A cytochrome P-450-mediated oxidation product of acetaminophen
-
DAHLIN, D. C., MIWA, G. T., LU, A. Y. H., and NELSON, S. D., 1984, N-acetyl-p-benzoquinone imine: A cytochrome P-450-mediated oxidation product of acetaminophen. Proceedings of the National Academy of Sciences, USA, 8, 1327-1331.
-
(1984)
Proceedings of the National Academy of Sciences, USA
, vol.8
, pp. 1327-1331
-
-
Dahlin, D.C.1
Miwa, G.T.2
Lu, A.Y.H.3
Nelson, S.D.4
-
9
-
-
0018164743
-
Partition coefficients of some alkyl derivatives of 4-acetamidophenol
-
DEARDEN, J. C., and O'HARA, J. H., 1978, Partition coefficients of some alkyl derivatives of 4-acetamidophenol. European Journal of Medical Chemistry - Chimica Therapeutica, 13, 415-419.
-
(1978)
European Journal of Medical Chemistry - Chimica Therapeutica
, vol.13
, pp. 415-419
-
-
Dearden, J.C.1
O'Hara, J.H.2
-
10
-
-
17344392789
-
A double-peaked quantitative structure-activity relationship (QSAR) in a series of paracetamol derivatives
-
DEARDEN, J. C., O'HARA, J. H., and TOWNEND, M. S., 1980, A double-peaked quantitative structure-activity relationship (QSAR) in a series of paracetamol derivatives. Journal of Pharmacy and Pharmacology, 32, 102P.
-
(1980)
Journal of Pharmacy and Pharmacology
, vol.32
-
-
Dearden, J.C.1
O'Hara, J.H.2
Townend, M.S.3
-
11
-
-
0019257128
-
Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines
-
FERNANDO, C. R., CALDER, I. C., and HAM, K. N., 1980, Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. Journal of Medicinal Chemistry, 23, 1153-1158.
-
(1980)
Journal of Medicinal Chemistry
, vol.23
, pp. 1153-1158
-
-
Fernando, C.R.1
Calder, I.C.2
Ham, K.N.3
-
12
-
-
0021242623
-
Stable free radical and benzoquinone imine metabolites of an acetaminophen analogue
-
FISCHER, V., and MASON, R. P., 1984, Stable free radical and benzoquinone imine metabolites of an acetaminophen analogue. Journal of Biological Chemistry, 259, 10284-10288.
-
(1984)
Journal of Biological Chemistry
, vol.259
, pp. 10284-10288
-
-
Fischer, V.1
Mason, R.P.2
-
13
-
-
0022272170
-
Free-radical metabolites of acetaminophen and a dimethylated derivative
-
FISCHER, V., WEST, P. R., HARMAN, L. S., and MASON, R. P., 1985, Free-radical metabolites of acetaminophen and a dimethylated derivative. Environmental Health Perspectives, 64, 127-137.
-
(1985)
Environmental Health Perspectives
, vol.64
, pp. 127-137
-
-
Fischer, V.1
West, P.R.2
Harman, L.S.3
Mason, R.P.4
-
14
-
-
0021268110
-
The formation and toxicity of catechol metabolites of acetaminophen in mice
-
FORTE, A. J., WILSON, J. M., SLATTERY, J. T., and NELSON, S. D., 1984, The formation and toxicity of catechol metabolites of acetaminophen in mice. Drug Metabolism and Disposition, 12, 484-491.
-
(1984)
Drug Metabolism and Disposition
, vol.12
, pp. 484-491
-
-
Forte, A.J.1
Wilson, J.M.2
Slattery, J.T.3
Nelson, S.D.4
-
15
-
-
0021363059
-
Cytochrome P-450 spin state: Inorganic biochemistry of haem iron ligation and functional significance
-
GIBSON, G. G., and TAMBURINI, P. P., 1984, Cytochrome P-450 spin state: inorganic biochemistry of haem iron ligation and functional significance. Xenobiotica, 14, 27-47.
-
(1984)
Xenobiotica
, vol.14
, pp. 27-47
-
-
Gibson, G.G.1
Tamburini, P.P.2
-
16
-
-
0022553963
-
Comparative toxicities and analgesic activities of three monomethylated analogues of acetaminophen
-
HARVISON, P. J., FORTE, A. J., and NELSON, S. D., 1986, Comparative toxicities and analgesic activities of three monomethylated analogues of acetaminophen. Journal of Medicinal Chemistry, 29, 1737-1743.
-
(1986)
Journal of Medicinal Chemistry
, vol.29
, pp. 1737-1743
-
-
Harvison, P.J.1
Forte, A.J.2
Nelson, S.D.3
-
17
-
-
0023947818
-
Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophen
-
HARVISON, P. J., GUENGERICH, F. P., RASHED, M. S., and NELSON, S. D., 1988, Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophen. Chemical Research in Toxicology, 1, 47-52.
-
(1988)
Chemical Research in Toxicology
, vol.1
, pp. 47-52
-
-
Harvison, P.J.1
Guengerich, F.P.2
Rashed, M.S.3
Nelson, S.D.4
-
18
-
-
0000855767
-
Biochemical toxicology of acetaminophen
-
edited by E. Hodgson, J. R. Bend, and R. M. Philpot (Amsterdam: Elsevier)
-
HINSON, J. A., 1980, Biochemical toxicology of acetaminophen. In Reviews in Biochemical Toxicology, edited by E. Hodgson, J. R. Bend, and R. M. Philpot (Amsterdam: Elsevier), pp. 103-129.
-
(1980)
Reviews in Biochemical Toxicology
, pp. 103-129
-
-
Hinson, J.A.1
-
19
-
-
0018965180
-
3-Hydroxyacetaminophen: A microsomal metabolite of acetaminophen. Evidence against an epoxide as the reactive metabolite of acetaminophen
-
HINSON, J. A., POHL, L. R., MONKS, T. J., GILLETTE, J. R., and GUENGERICH, F. P., 1980, 3-Hydroxyacetaminophen: A microsomal metabolite of acetaminophen. Evidence against an epoxide as the reactive metabolite of acetaminophen. Drug Metabolism and Disposition, 8, 289-294.
-
(1980)
Drug Metabolism and Disposition
, vol.8
, pp. 289-294
-
-
Hinson, J.A.1
Pohl, L.R.2
Monks, T.J.3
Gillette, J.R.4
Guengerich, F.P.5
-
20
-
-
0025307694
-
Mechanism of paracetamol toxicity
-
24 March
-
HINSON, J. A., ROBERTS, D. W., BENSON, R. W., DALHOFF, K., LOFT, S., and POULSEN, H. E., 1990, Mechanism of paracetamol toxicity. Lancet, 24 March.
-
(1990)
Lancet
-
-
Hinson, J.A.1
Roberts, D.W.2
Benson, R.W.3
Dalhoff, K.4
Loft, S.5
Poulsen, H.E.6
-
21
-
-
0017794351
-
Measurement of substrate and inhibitor binding to microsomal cytochrome P-450 by optical-difference spectroscopy
-
JEFCOATE, C. R., 1978, Measurement of substrate and inhibitor binding to microsomal cytochrome P-450 by optical-difference spectroscopy. Methods of Enzymology, 52, 258-279.
-
(1978)
Methods of Enzymology
, vol.52
, pp. 258-279
-
-
Jefcoate, C.R.1
-
22
-
-
0015754446
-
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo
-
JOLLOW, D. J., MITCHELL, J. R., POTTER, W. Z., DAVIS, D. C., GILLETTE, J. R., and BRODIE, B. B., 1973, Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. Journal of Pharmacology and Experimental Therapeutics, 187, 195-202.
-
(1973)
Journal of Pharmacology and Experimental Therapeutics
, vol.187
, pp. 195-202
-
-
Jollow, D.J.1
Mitchell, J.R.2
Potter, W.Z.3
Davis, D.C.4
Gillette, J.R.5
Brodie, B.B.6
-
23
-
-
0023553590
-
Structural requirements for substrates of cytochromes P-450 and P-448
-
LEWIS, D. F. V., IOANNIDES, C., and PARKE, D. F., 1987, Structural requirements for substrates of cytochromes P-450 and P-448. Chemico-Biological Interactions, 64, 39-60.
-
(1987)
Chemico-Biological Interactions
, vol.64
, pp. 39-60
-
-
Lewis, D.F.V.1
Ioannides, C.2
Parke, D.F.3
-
24
-
-
71849104860
-
Protein measurement with the Folin phenol reagent
-
LOWRY, O. H., ROSEBROUGH, N. J., FARR, A. L., and RANDALL, R. J., 1951, Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265-275.
-
(1951)
Journal of Biological Chemistry
, vol.193
, pp. 265-275
-
-
Lowry, O.H.1
Rosebrough, N.J.2
Farr, A.L.3
Randall, R.J.4
-
25
-
-
0018077397
-
Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse
-
MOLDÉUS, P., 1978, Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse. Biochemical Pharmacology, 27, 2859-2863.
-
(1978)
Biochemical Pharmacology
, vol.27
, pp. 2859-2863
-
-
Moldéus, P.1
-
26
-
-
0020050309
-
Prostaglandin synthetase catalyzed activation of paracetamol
-
MOLDÉUS, P., ANDERSSON, B., RAHIMTULA, A., and BERGGREN, M., 1982, Prostaglandin synthetase catalyzed activation of paracetamol. Biochemical Pharmacology, 31, 1363-1368.
-
(1982)
Biochemical Pharmacology
, vol.31
, pp. 1363-1368
-
-
Moldéus, P.1
Andersson, B.2
Rahimtula, A.3
Berggren, M.4
-
27
-
-
0028346020
-
Preferred orientations in the binding of 4′-hydroxyacetanilide (acetaminophen) to cytochrome-P450 1A1 and 2B1 isoforms as determined by C-13-NMR and N-15-NMR relaxation studies
-
MYERS, T. G., THUMMEL, K. E., KALHORN, T. F., and NELSON, S. D., 1994, Preferred orientations in the binding of 4′-hydroxyacetanilide (acetaminophen) to cytochrome-P450 1A1 and 2B1 isoforms as determined by C-13-NMR and N-15-NMR relaxation studies. Journal of Medicinal Chemistry, 37, 860-867.
-
(1994)
Journal of Medicinal Chemistry
, vol.37
, pp. 860-867
-
-
Myers, T.G.1
Thummel, K.E.2
Kalhorn, T.F.3
Nelson, S.D.4
-
28
-
-
0027304762
-
Cytochrome P450 enzymes involved in acetaminophen activation by rat liver microsomes and their kinetics
-
PATTEN, C. J., THOMAS, P. E., GUY, R. L., LEE, M., GONZALEZ, F. J., GUENGERICH, F. P., and YANG, C. S., 1993, Cytochrome P450 enzymes involved in acetaminophen activation by rat liver microsomes and their kinetics. Chemical Research in Toxicology, 6, 511-518.
-
(1993)
Chemical Research in Toxicology
, vol.6
, pp. 511-518
-
-
Patten, C.J.1
Thomas, P.E.2
Guy, R.L.3
Lee, M.4
Gonzalez, F.J.5
Guengerich, F.P.6
Yang, C.S.7
-
29
-
-
0015738695
-
Acetaminophen-induced hepatic necrosis. III. Cytochrome P-450-mediated covalent binding in vitro
-
POTTER, W. Z., DAVIS, D. C., MITCHELL, J. R., JOLLOW, D. J., GILLETTE, J. R., and BRODIE, B. B., 1973, Acetaminophen-induced hepatic necrosis. III. Cytochrome P-450-mediated covalent binding in vitro. Journal of Pharmacological and Experimental Therapeutics, 187, 203-210.
-
(1973)
Journal of Pharmacological and Experimental Therapeutics
, vol.187
, pp. 203-210
-
-
Potter, W.Z.1
Davis, D.C.2
Mitchell, J.R.3
Jollow, D.J.4
Gillette, J.R.5
Brodie, B.B.6
-
30
-
-
0020600559
-
Paracetamol overdosage. Pharmacological considerations and clinical managements
-
PRESCOTT, L. F., 1983, Paracetamol overdosage. Pharmacological considerations and clinical managements. Drugs, 25, 290-314.
-
(1983)
Drugs
, vol.25
, pp. 290-314
-
-
Prescott, L.F.1
-
31
-
-
0023691709
-
Determination of gluthathione in biological material by flow-injection analysis using an enzymatic recycling reaction
-
REDEGELD, F. A. M., VAN OPSTAL, M. A. J., HOUDKAMP, E., and VAN BENNEKOM, W. P., 1988, Determination of gluthathione in biological material by flow-injection analysis using an enzymatic recycling reaction. Analytical Biochemistry, 174, 489-495.
-
(1988)
Analytical Biochemistry
, vol.174
, pp. 489-495
-
-
Redegeld, F.A.M.1
Van Opstal, M.A.J.2
Houdkamp, E.3
Van Bennekom, W.P.4
-
33
-
-
0022532602
-
Alkaline hydrolysis of NEM allows a rapid assay of GSSG in biological samples
-
SACCHETTA, P., DI COLA, D., and FEDERICI, G., 1986, Alkaline hydrolysis of NEM allows a rapid assay of GSSG in biological samples. Analytical Biochemistry, 154, 205-208.
-
(1986)
Analytical Biochemistry
, vol.154
, pp. 205-208
-
-
Sacchetta, P.1
Di Cola, D.2
Federici, G.3
-
34
-
-
0014059179
-
Spectral studies of drug interaction with hepatic microsomal cytochrome P-450
-
SCHENKMAN, J. B., REMMER, H., and ESTABROOK, R. W., 1967, Spectral studies of drug interaction with hepatic microsomal cytochrome P-450. Molecular Pharmacology, 3, 113-123.
-
(1967)
Molecular Pharmacology
, vol.3
, pp. 113-123
-
-
Schenkman, J.B.1
Remmer, H.2
Estabrook, R.W.3
-
35
-
-
0025753921
-
Identification of epoxide-derived and quinone-derived bromobenzene adducts to protein sulfur nucleophiles
-
SLAUGHTER, D. E., and HANZLIK, R. P., 1991, Identification of epoxide-derived and quinone-derived bromobenzene adducts to protein sulfur nucleophiles. Chemical Research in Toxicology, 4, 349-359.
-
(1991)
Chemical Research in Toxicology
, vol.4
, pp. 349-359
-
-
Slaughter, D.E.1
Hanzlik, R.P.2
-
36
-
-
84879282747
-
Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives. Comparison of their microsomal cytochrome P-450 dependent oxidation and toxicity in freshly isolated hepatocytes
-
VAN DE STRAAT, R., DE VRIES, J., KULKENS, T., DEBETS, A. J. J., and VERMEULEN, N. P. E., 1986, Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives. Comparison of their microsomal cytochrome P-450 dependent oxidation and toxicity in freshly isolated hepatocytes. Biochemical Pharmacology, 35, 3693-3699.
-
(1986)
Biochemical Pharmacology
, vol.35
, pp. 3693-3699
-
-
Van De Straat, R.1
De Vries, J.2
Kulkens, T.3
Debets, A.J.J.4
Vermeulen, N.P.E.5
-
37
-
-
0023232345
-
Relationship between paracetamol binding to and its oxidation by two cytochrome P-450 isozymes - A proton nuclear magnetic resonance and spectrophotometric study
-
VAN DE STRAAT, R., DE VRIES, J., DE BOER, H. J. R., VROMANS, R. M., and VERMEULEN, N. P. E., 1987a, Relationship between paracetamol binding to and its oxidation by two cytochrome P-450 isozymes - a proton nuclear magnetic resonance and spectrophotometric study. Xenobiotica, 17, 1-9.
-
(1987)
Xenobiotica
, vol.17
, pp. 1-9
-
-
Van De Straat, R.1
De Vries, J.2
De Boer, H.J.R.3
Vromans, R.M.4
Vermeulen, N.P.E.5
-
38
-
-
0023217776
-
Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives : Comparison of their hepatotoxicity in mice
-
VAN DE STRAAT, R., DE VRIES, J., GROOT, E. J., ZIJL, R., and VERMEULEN, N. P. E., 1987b, Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives : comparison of their hepatotoxicity in mice. Toxicology and Applied Pharmacology, 89, 183-189.
-
(1987)
Toxicology and Applied Pharmacology
, vol.89
, pp. 183-189
-
-
Van De Straat, R.1
De Vries, J.2
Groot, E.J.3
Zijl, R.4
Vermeulen, N.P.E.5
-
39
-
-
0026691008
-
Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention
-
VERMEULEN, N. P. E., BESSEMS, J. G. M., and VAN DE STRAAT, R., 1992, Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention. Drug Metabolism Reviews, 24, 367-407.
-
(1992)
Drug Metabolism Reviews
, vol.24
, pp. 367-407
-
-
Vermeulen, N.P.E.1
Bessems, J.G.M.2
Van De Straat, R.3
-
40
-
-
8944229023
-
Mass spectra of quinones
-
edited by S. Patai (New York: Wiley)
-
ZELLER, K.-P., 1974, Mass spectra of quinones in The chemistry of the Quinoid compounds. Part 1, edited by S. Patai (New York: Wiley), pp. 236-238.
-
(1974)
The Chemistry of the Quinoid Compounds. Part 1
, pp. 236-238
-
-
Zeller, K.-P.1
|