A single-chain Fv reactive with the goodpasture antigen

Laboratory Investigation

Volumn 74, Issue 6, 1996, Pages 1051-1059

  Ross, Calum N ^a   Turner, Neil ^a   Savage, Philip ^a   Cashman, Stephen J ^a   Spooner, Robert A ^a   Pusey, Charles D ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; COLLAGEN TYPE 4; COMPLEMENTARY DNA; MEMBRANE ANTIGEN;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ANTIGEN EXPRESSION; ARTICLE; GLOMERULUS BASEMENT MEMBRANE; GOODPASTURE SYNDROME; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN FOLDING;

AMINO ACID SEQUENCE; AUTOANTIGENS; BASE SEQUENCE; BINDING SITES, ANTIBODY; CLONING, MOLECULAR; COLLAGEN; COLLAGEN TYPE IV; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA;

EID: 0029953790     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Barker DF, Hostikka SL, Zhou J, Chow LT, Oliphant AR, Gerken SC, Gregory MC, Skolnick MH, Atkin CL, and Tryggvason K (1990). Identification of mutations in the COL4A5 collagen gene in Alport syndrome. Science 248:1224-1227.
2. Better M, Chang CP, Robinson RR, and Horwitz AH (1988). Escherichia coll secretion of an active chimeric antibody fragment. Science 240:1041-1043.
3. Bird RE, Hardman KD, Jacobson JW, Johnson S, Kaufman BM, Lee S, Lee T, Pope SH, Riordan GS, and Whitlow M (1988). Single-chain antigen-binding proteins. Science 242: 423-426.
4. Bowman C and Lockwood CM (1985). Clinical application of a radio-immunoassay for auto-antibodies to glomerular basement membrane. J Clin Lab Immunol 17:197-202.
5. Butkowski RJ, Langveld JPM, Wieslander J, Hamilton J, and Hudson BG (1987). Localization of the Goodpasture epitope to a novel chain of basement membrane collagen. J Biol Chem 262:7874-7877.
6. Butkowski RJ, Wieslander J, Wisdom BJ, Barr JF, Nöelken ME, and Hudson BG (1985). Properties of the globular domain of type IV collagen and its relationship to the Goodpasture antigen. J Biol Chem 260:3739-3747.
7. Cashman SJ, Pusey CD, and Evans DJ (1988). Extraglomerular distribution of immunoreactive Goodpasture antigen. J Pathol 155:61-70.
8. Colcher D, Bird R, Roselli M, Hardman KD, Johnson S, Pope S, Dodd SW, Pantoliano MW, Milenic DE, and Schlom J (1990). In vivo tumor targeting of a recombinant single-chain antigen-binding protein. J Natl Cancer Inst 82:1191-1197.
9. Derry CJ, Dunn MJ, Rees AJ, and Pusey CD (1991). Restricted specificity of the autoantibody response in Goodpasture's syndrome demonstrated by two-dimensional Western blotting. Clin Exp Immunol 86:457-463.
10. Devey ME, Bleasdale K, Lee S, and Rath S (1988). Determination of the functional affinity of IgG1 and IgG4 antibodies to tetanus toxoid by isotype-specific solid-phase assays. J Immunol Methods 106:119-125.
11. Eshar Z, Waks T, Gross G, and Schindler DG (1993). Specific activation and targeting of cytotoxoc lymphocytes through chimeric single chains consisting of antibody-binding domains and the γ or ζ subunits of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci USA 90:720-724.
12. Gandecha AR, Owen MRL, Cockburn B, and Whitelam GC (1992). Production and secretion of a bifunctional staphylococcal protein A::antiphytochrome single-chain Fv fusion protein in Escherichia coli. Gene 122:361-365.
13. Gunwar S, Saus J, Nöelken ME, and Hudson BG (1989). Glomerular basement membrane: Identification of a fourth chain, α4, of type IV collagen. J Biol Chem 265:5466-5469.
14. Holvoet P, Laroche Y, Lijnen HR, Van-Hoef B, Brouwers E, De-Cock F, Lauwereys M, Gansemans Y, and Collen D (1992). Biochemical characterization of single-chain chimeric plasminogen activators consisting of a single-chain Fv fragment of a fibrin-specific antibody and single-chain urokinase. Eur J Biochem 210:945-952.
15. Hostikka SL, Eddy RL, Byers MG, Höyhtyä M, Shows TB, and Trygvasson K (1990). Identification of a distinct type IV collagen a chain with restricted kidney distribution and assignment of its gene to the locus of X chromosome-linked Alport syndrome. Proc Natl Acad Sci USA 87:1606-1610.
16. Huston JS, Levinson D, Mudgett-Hunter M, Tai M, Novotny J, Margolies MN, Ridge RJ, Bruccoleri RE, Haber E, Crea R, and Oppermann H (1988). Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc Natl Acad Sci USA 85:5879-5883.
17. Kavaler J, Caton AJ, Staudt LM, Schwartz D, and Gerhard W (1990). A set of closely related antibodies dominates the primary antibody response to the antigenic site CB of the A/PR/8/34 influenza virus hemagglutinin. J Immunol 445: 2312-2321.
18. Kleppel MM, Kashtan CE, Butkowski RJ, Fish AJ, and Michael AF (1987). Alport familial nephritis: Absence of 28 kilodalton non-collagenous monomers of type IV collagen in glomerular basement membrane. J Clin Invest 80:263-266.
19. Kleppel MM, Kashtan C, Santi PA, Wieslander J, and Michael AF (1989). Distribution of familial nephritis antigen in normal tissue and renal basement membranes of patients with homozygous and heterozygous Alport familial nephritis: Relationship of familial nephritis and Goodpasture antigens to novel collagen chains and type IV collagen. Lab Invest 61:278-289.
20. Knapp MR, Liu C, Newell N, Ward RB, Tucker PW, Strober S, and Blattner F (1982). Simultaneous expression of immunoglobulin μ and δ heavy chains by a cloned B-cell lymphoma: A single copy of the VH gene is shared by two adjacent CH genes. Proc Natl Acad Sci USA 79:2996-3000.
21. Morrison KE, Germino GG, and Reeders ST (1991a). Use of the polymerase chain reaction to clone and sequence a cDNA encoding the bovine α3 chain of type IV collagen. J Biol Chem 266:34-39.
22. Morrison KE, Mariyama M, Yang-Feng TL, and Reeders ST (1991b). Sequence and localization of a partial cDNA encoding the human α3 chain of type IV collagen. Am J Hum Genet 49:545-554.
23. Netzer K, Renders L, Zhou J, Pullig O, Tryggvason K, and Weber M (1992). Deletions of the COL4A5 gene in patients with Alport syndrome. Kidney Int 42:1336-1344.
24. Orlandi R, Gussow DH, Jones PT, and Winter G (1989). Cloning immunoglobulin variable domains for expression by the polymerase chain reaction. Proc Natl Acad Sci USA 86:3833-3837.
25. Pantoliano MW, Bird RE, Johnson S, Asel ED, Dodd SW, Wood JF, and Hardman KD (1991). Conformational stability, folding, and ligand-binding affinity of single-chain Fv immunoglobulin fragments expressed in Escherichia coli. Biochemistry 30:10117.
26. Pihlajaniemi T, Pohjolainen E, and Myers JC (1990). Complete primary structure of the triple-helical region and the carboxyl-terminal domain of a new type IV collagen chain, α5(IV). J Biol Chem 265:13758-13766.
27. Plückthun A (1992). Mono- and bivalent antibody fragments produced in Escherichia coli: Engineering, folding and antigen binding. Immunol Rev 130:151-188.
28. Pusey CD, Dash A, Kershaw MJ, Morgan A, Reilly A, Rees AJ, and Lockwood CM (1987). A single autoantigen in Goodpasture's syndrome identified by a monoclonal antibody to human glomerular basement membrane. Lab Invest 56:23-31.
29. Saus J, Wieslander J, Langveld JPM, Quinones S, and Hudson BG (1988). Identification of the Goodpasture antigen as the α3(IV) chain of collagen IV. J Biol Chem 263:13374-13380.
30. Savage CO, Pusey CD, Kershaw MJ, Cashman SJ, Harrison P, Hartley B, Turner DR, Cameron JS, Evans DJ, and Lockwoood CM (1986). The Goodpasture antigen in Alport's syndrome: Studies with a monoclonal antibody. Kidney Int 30:107-112.
31. Savage P, So A, Spooner RA, and Epenetos AA (1993). A recombinant single chain antibody interleukin-2 fusion protein. Br J Cancer 67:304-310.
32. Saxena R, Isaksson V, Bygren P, and Wieslander J (1989). A rapid assay for circulating anti-glomerular basement membrane antibodies in Goodpasture syndrome. J Immunol Methods 118:73-78.
33. Skerra A and Plückthun A (1988). Assembly of a functional immunoglobulin Fv fragment in Escherichia coli. Science 240:1038-1041.
34. Towbin H, Staehelin T, and Gordon J (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354.
35. Turner N, Mason PJ, Brown R, Fox M, Povey S, Rees A, and Pusey CD (1992). Molecular cloning of the human Goodpasture antigen demonstrates it to be the α3 chain of type IV collagen. J Clin Invest 89:592-601.
36. Weber S, Engel J, Wiedemann H, Glanville RW, and Timpl R (1984). Subunit structure and assembly of the globular domain of basement-membrane collagen type IV. Eur J Biochem 139:401-410.
37. Wels W, Harwerth I, Mueller M, Groner B, and Hynes NE (1992). Selective inhibition of tumor cell growth by a recombinant single-chain antibody-toxin specific for the erb-2 receptor. Cancer Res 52:6310-6317.
38. Wieslander J, Bygren P, and Heinegard D (1984). Isolation of the specific glomerular basement membrane antigen involved in Goodpasture syndrome. Proc Natl Acad Sci USA 81:1544-1548.
39. Wilson CB and Dixon FJ (1981). The renal response to immunological injury. In: Brenner BM and Rector FC, editors. The kidney. Philadelphia: WB Saunders, 1237-1350.
40. Yokota T, Milenic DE, Whitlow M, and Schlom J (1992). Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms. Cancer Res 52:3402-3408.
41. Zhou J, Ding M, Zhao Z, and Reeders ST (1994). Complete primary structure of the sixth chain of human basement membrane collage, α6(IV): Isolation of the cDNAs for α6(IV) and comparison with five other type IV collagen chains. J Biol Chem 269:13193.