Assay of four stereoisomers of desacetyl diltiazem hydrochloride. Application to in vitro chiral inversion studies

Chromatographia

Volumn 43, Issue 7-8, 1996, Pages 413-418

  Ishii, K ^a   Wakamoto, S ^a   Nakai, H ^a   Sato, T ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Chiral inversion; Chiralcel OF; Column liquid chromatography; Desacetyl diltiazem hydrochloride stereoisomers; Epimerization

Indexed keywords

DEACETYLDILTIAZEM;

ARTICLE; DRUG DEGRADATION; DRUG ISOLATION; DRUG PURIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEREOISOMERISM; TECHNIQUE; ULTRAVIOLET IRRADIATION;

EID: 0029953361     PISSN: 00095893     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02271021     Document Type: Article

References (11)

1. F. Jamali, R. Mehvar, F. M. Pasutto, J. Pharm. Sci. 78, 695 (1989).
2. R. F. N. Mills, S. S. Adams, E. E. Cliffe, W. Dickinson, J. S. Nicholson, Xenobiotica 3, 589 (1973).
3. M. Chaffman, R. N. Brodgen, Drugs 29, 387 (1985).
4. M. T. Buckley, S. M. Grant, K. L. Goa, D. Mc Tavish, E. M. Sorkin, Drugs 39, 757 (1990).
5. R. Shimizu, K. Ishii, N. Tsumagari, M. Tanigawa, M. Matsumoto, J. Chromatogr. 253, 101 (1982).
6. R. Shimizu, T. Kakimoto, K. Ishii, Y. Fujimoto, H. Nishi, N. Tsumagari, J. Chromatogr. 357, 119 (1986).
7. H. Nishi, N. Fujimura, H. Yamaguchi, T. Fukuyama, Chromatographia 35, 305 (1993).
8. K. Ishii, K. Minato, H. Nakai, T. Sato, Chromatographia 41, 450 (1995).
9. H. Kugita, H. Inoue, M. Ikezaki, S. Takeo, Chem. Pharm. Bull. 18, 2028 (1970).
10. H. Kugita, H. Inoue, M. Ikezaki, M. Konda, S. Takeo, Chem. Pharm. Bull. 18, 2284 (1970).
11. H. Kugita, H. Inoue, M. Ikezaki, M. Konda, S. Takeo, Chem. Pharm. Bull 19, 595 (1971).