Distribution of the predominant hepatitis B virus precore variants in hepatitis B e antigen-positive children and their effect on treatment response

Pediatric Research

Volumn 39, Issue 6, 1996, Pages 980-984

  Cabrerizo, María ^a,c   Bartolomé, Javier ^a,c   Ruiz Moreno, Mercedes ^b   Otero, Manuela ^b   López Alcorocho, Juan Manuel ^a,c   Carreño, Vicente ^a,c  

^a Hepatology Unit   (Spain)

^b Hospital UniversitarioFundación Jiménez Díaz   (Spain)

^c Fundacion Estudio Hepatitis Virales   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN; RECOMBINANT ALPHA INTERFERON; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ALPHA2B INTERFERON; VIRUS DNA;

ADOLESCENT; ARTICLE; CHILD; CHRONIC HEPATITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GEOGRAPHIC DISTRIBUTION; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; LIVER HISTOLOGY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TREATMENT OUTCOME; VIREMIA; VIRUS GENOME; VIRUS MUTANT; VIRUS MUTATION;

EID: 0029953332     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199606000-00009     Document Type: Article

References (26)

1. Carman WF, Hadziyannis S, McGarvey MJ, Jacyna MR, Karayiannis P, Makris A, Thomas HC 1989 Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 2:588-590
2. Brunetto MR, Stemler M, Schödel F, Will H, Ottobrelli A, Rizzetto M, Verme G, Bonino F 1989 Identification of HBV variants which cannot produce precore derived HBeAg and which may be responsible for severe hepatitis. Ital J Gastroenterol 21:151-154
3. Bhat RA, Ulrich PP, Vyas NC 1990 Molecular characterization of a new variant of hepatitis B virus in a persistently infected homosexual man. Hepatology 11:271-276
4. Brunetto MR, Stemler M, Bonino F, Schödel F, Oliven F, Rizzetto M, Verme G, Will H 1990 A new hepatitis B virus strain in patients with severe anti-HBe positive chronic hepatitis B. J Hepatol 10:258-260
5. Fiordalisi G, Cariani E, Mantero G, Zanetti A, Tanzi E, Chiaramonte M, Primi D 1990 High genomic variability in the pre-c of hepatitis B virus in anti-HBe, HBV DNA-positive chronic hepatitis. J Med Virol 31:297-300
6. Raimondo G, Schneider R, Stemler M, Smedile V, Rodino G, Will H 1990 A new hepatitis B virus variant in a chronic carrier with multiple episodes of viral reactivation and acute hepatitis. Virology 179:74-78
7. Carman WF, Ferraro M, Lok ASF, Ma OCK, Lai CL, Thomas HC 1992 Precore sequence variation in Chinese isolates of hepatitis B virus. J Infect Dis 165:127-133
8. Carman WF, Hadziyannis S, Karayiannis P, Fagan EA, Tassopoulos NC, Williams R, Thomas HC 1991 Association of the precore variant of HBV with acute and fulminant hepatitis B infection. In: Hollinger FB, Lemon SM, Margolis H (eds) Viral hepatitis and Liver Disease. Williams & Wilkins, Baltimore, pp 216-219
9. Brunetto MR, Giarin M, Oliveri F, Chiaberge E, Baldi M, Alfarano A, Serra A, Saracco G, Verme G 1991 Wild type and e antigen-minus hepatitis B viruses and course of chronic hepatitis. Proc Natl Acad Sci USA 88:4186-4190
10. Brunetto MR, Giarin M, Saracco G, Oliveri F, Calvo P, Capra G, Randone A, Abate ML, Manzini P, Capalbo M, Piantino P, Verme G, Bonino F 1993 Hepatitis B virus unable to secrete e antigen and response to interferon in chronic hepatitis B. Gastroenterology 105:845-850
11. Brunetto MR, Giarin M, Oliveri F, Saracco G, Barbara C, Parrella T, Abate ML, Chiaberge E. Calvo PL, Manzini P, Verme G, Bonino F 1991 "e" antigen defective hepatitis B virus and course of chronic infection. J Hepatol 13(suppl 4):S82-S86
12. Berninger M, Hammer M, Hoyer B, Gerin J 1982 An assay for the detection of the DNA genome of hepatitis B virus in serum. J Med Virol 9:57-68
13. Galibert F, Mandart E, Fitoussi F, Tiollais P, Charnay P 1979 Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature 281:646-650
14. López-Alcorocho JM, Moraleda G, Bartolomé J, Castillo I, Cotonat T, Aguilar J, Ortega E, Pons JA, Salmerón J, Vázquez-Iglesias JL, Carreño V 1994 Analysis of hepatitis B precore region in serum and liver of chronic hepatitis B virus carriers. J Hepatol 21:353-360
15. Sanger F, Nicklen S, Coulson R 1977 DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74:5463-5467
16. Günther S, Meisel H, Reip A, Miska S, Krüger DH, Will H 1992 Frequent rapid emergence of mutated pre-C sequences in HBV from e-antigen positive carriers who seroconverted to anti-HBe during interferon treatment. Virology 187:271-279
17. Goergen B, Meyer Zum Buschenfelde KH, Gerken G 1994 Mutation specific PCR and direct solid phase sequencing assay for the detection of hepatitis B virus pre-c/c mutants in anti-HBe positive, chronic hepatitis B. J Med Virol 43:97-102
18. Tong S, Li J, Vitvitski L, Trépo C 1992 Replication capacities of natural and artificial precore stop codon mutants of hepatitis B virus: relevance of pregenome encapsidation signal. Virology 191:237-45
19. Li J, Tong S, Wen Y, Vitvitski L, Zhang Q, Trépo C 1993 Hepatitis B virus genotype A rarely circulates as an HBe-minus mutant: possible contribution of a single nucleotide in the precore region. J Virol 67:5402-5410
20. Tong S, Li J, Vitvitski L, Kay A, Trépo C 1993 Evidence for a base-paired region of hepatitis B virus pregenome encapsidation signal which influences the patterns of precore mutations abolishing HBe protein expression. J Virol 67:5651-5655
21. Lamberts C, Nassal M, Velhagen I, Zentgraf H, Schröder CH 1994 Precore-mediated inhibition of hepatitis B virus progeny DNA synthesis. J Virol 67:3756-3762
22. Li J, Tong S, Vitvitski L, Zoulim F, Trépo C 1991 Rapid detection of infection with hepatitis B virus variants containing a stop codon in the distal preC region. In: Hollinger FB, Lemon SM, Margolis H (eds) Viral Hepatitis and Liver Disease. Williams & Wilkins, Baltimore, pp 216-219
23. Brown JL, Carman WF, Thomas HC 1992 The clinical significance of molecular variation within the hepatitis B virus genome. Hepatology 15:144-148
24. Ruiz-Moreno M, Camps T, Jiménez J, López R, Castillo I, Bartolomé J, Carreño V 1995 Factors predictive of response to Interferon therapy in children with chronic hepatitis B. J Hepatol 22:540-544
25. Brook MG, Karayiannis P, Thomas HC 1989 Which patients with chronic hepatitis B virus infection will respond to alpha interferon therapy? A statistical analysis of predictive factors. Hepatology 10:761-763
26. Mora I, Porres JC, Bartolomé J, Quiroga JA, Gutiez J, Hernández-Guío C, Bas C, Carreño V 1987 Changes in hepatitis B virus (HBV) markers during prolonged recombinant interferon alpha-2A treatment of chronic HBV infection. J Hepatol 4:29-36