Inhibitory effect of folinic acid on radiation-induced micronuclei and chromosomal aberrations in V79 cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 352, Issue 1-2, 1996, Pages 123-134

  Keshava, C ^a   Nagalakshmi, R ^a   Ong, T ^a,b   Nath, J ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Anti mutagen; Chromosomal aberration; Folinic acid (leucovorin); Micronucleus; UV radiation; V79 cell; X ray

Indexed keywords

ANTIMUTAGENIC AGENT; FOLINIC ACID;

ANIMAL CELL; ARTICLE; CELL STRAIN V 79; CHINESE HAMSTER; CHROMOSOME DAMAGE; CYTOTOXICITY; DOSE RESPONSE; LUNG ALVEOLUS CELL; MICRONUCLEUS TEST; MITOSIS INDEX; NONHUMAN; PRIORITY JOURNAL; RADIATION PROTECTION; RADIATION RESPONSE; STRUCTURAL CHROMOSOME ABERRATION; ULTRAVIOLET IRRADIATION; X IRRADIATION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0029952603     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(96)00018-8     Document Type: Article

References (27)

1. Bender, M.A. (1979) Relationship of DNA lesion and their repair to chromosomal aberration production, in: W.M. Generoso, M.D. Shelby and F.J. de Serres (Eds.), DNA Repair and Mutagenesis in Eukaryotes, Plenum Press, New York, pp. 245-265.
2. Bender, M.A, H.G. Griggs and J.S. Bedford (1974) Mechanisms of chromosomal aberration production. III. Chemical and ionizing radiation, Mutation Res., 23, 197-212.
3. Branda, R.F. and D.B. Blickensderfer (1993) Folate deficiency increases genetic damage caused by alkylating agents and γ-irradiation in Chinese hamster ovary cells, Cancer Res., 53, 5401-5408.
4. Burres, N.S., and C.E. Cass (1987) Inhibition of methotrexate-induced differentiation of cultured human choriocarcinoma (BeWo) cells by thymidine, Cancer Res., 47, 5059-5064.
5. Cleaver, J.E. (1968) Defective repair replication in xeroderma pigmentosum, Nature (Lond.), 218, 652-656.
6. Cohen, M.A., M.S. Bartlett and J.W. Smith (1986) Trimethorexate: Activity versus Pneumocystis carinii in tissue culture, Reseach Report (Memo) 750-00231.
7. Cossins, E.A. (1984) in: R.L. Blakely and S.J. Benkovic (Eds.), Folates and Pterins, Vol. 1, Wiley & Sons, pp. 1-60.
8. Countryman, P. and J.A. Heddle (1976) The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes, Mutation Res., 41, 321-332.
9. FDA, Food and Drug Administration (1993) FDA bans unproven health claims by makers of some diet supplements, B4 Wall Street Journal, 12/30/93.
10. Fenech, M. and S. Neville (1992) Conversion of excision-repairable DNA lesions to micronuclei within one cell cycle in human lymphocytes, Environ. Mol. Mutagen., 19, 27-36.
11. Galloway, S.M., M.J. Aardema, M. Ishidate Jr., J.L. Ivett, D.J. Kirkland, T. Morita, P. Mosesso and T. Sofuni (1994) Report from working group on in vitro tests for chromosomal aberrations, Mutation Res., 312, 241-261.
12. Hartley-Asp, G., H.C. Andersson, S. Sturelid and B.A. Kihlman (1980) G2 repair and the formation of chromosomal aberrations. I. The effect of hydroxyurea and caffeine on maleic hydrazide-induced chromosome damage in Vicia faba. Environ. Exp. Bot., 20, 119-129.
13. Home, D.W., D. Patterson and R.J. Cook (1989) Effect of nitrous oxide inactivation of vitamin B12-dependent methionine synthetase on the subcellular distribution of folate coenzymes in rat liver. Arch. Biochem. Biophys., 270, 729-733.
14. Keshava, C., T. Ong and J. Nath (1995) Comparative studies on radiation-induced micronuclei and chromosomal aberrations in V79 cells, Mutation Res., 328, 63-71.
15. Kihlman, B.A., K. Hanssan and H.C. Andersson (1982) The effects of post-treatments with caffeine during S and G2 on the frequencies of chromosomal aberrations induced thio-tepa in root tips of Vicia faba, Environ. Exp. Bot., 20, 271-286.
16. Krishna, G., M.K. Kropko and J.C. Theiss (1989) Use of the cytokinesis-block method for the analysis of micronuclei in V79 Chinese hamster lung cells: results with mitomycin C and cyclophosphamide, Mutation Res., 222, 63-69.
17. Krishna, G., R. Fiedler and J.C. Theiss (1992) Simultaneous analysis of chromosome damage and aneuploidy in cytokinesis-blocked V79 Chinese hamster lung cells using an anitkinetochore antibody, Mutation Res., 282, 79-88.
18. Libbus, B.L., L.S. Borman., C.H. Ventrone and R.F. Branda (1990) Nutritional folate-deficiency in Chinese hamster ovary cells, chromosomal abnormalities associated with perturbations in nucleic acid precursors, Cancer Genet. Cytogenet., 46, 231-242.
19. Littlefield, L.G., A.M. Sayer and E.L. Frome (1989) Comparisons of dose-response parameters for radiation-induced acentric fragments and micronuclei observed in cytokinesis-arrested lymphocytes, Mutagenesis, 4, 265-70.
20. Maity, A., W.G. Mc Kenna and R.J. Muschel (1994) The molecular basis for cell cycle delays following ionizing radiation: a review, Radiother. Oncol., 31, 1-13.
21. Natarajan, A.T. (1984) Origin and significance of chromosomal aberrations, in: G. Obe (Ed.), Mutations in Man. Springer-Verlag, Berlin, Heidelberg, pp. 156-176.
22. Natarajan, A.T., A.A. van Zeeland, E.A.M. Verdegatal-Immerseel and A.R. Filon (1980) Studies on the influence of photoreactivation on the frequencies of UV-induced chromosomal aberrations, sister chromatid exchanges and pyrimidine dimers in chicken embryonic fibroblasts, Mutation Res., 69, 307-317.
23. Pienkowska, K. and J. Koziorowska (1986) Influence of folinic acid (Leucovorin) on the cytostatic and cytogenetic effects of methotrexate, Folia Medica Cracoviensia, 27, 239-244.
24. Roberts C.J., G.R. Morgan and P.D. Holt (1986) A critical comparison of the micronucleus yield from high and low LET irradiation of plateau phase cell population, Mutation Res., 160, 237-242.
25. Strange, C.J. (1995) Thwarting skin cancer with sun sense, FDA consumer, July/Aug. 95, 10-14.
26. Theiss, J.C., G. Krishna, M. Kropko and V. Ciaravino (1989) Effect of leucovorin on the in vitro cytotoxic and clastogenic activity of trimetrexate, Proc. Am. Assoc. Cancer Res., 30, 472.
27. Van Zeeland, A.A., A.T. Natarajan and E.A.M. Verdegaal-Immerzeel (1980) Photoreactivation of UV-induced cell killing, chromosome aberrations, sister chromatid exchanges, mutations and pyrimidine dimers in Xenopus laevis fibroblasts, Mol. Genet., 180, 495-500.