Fixation traps formyl peptide receptors in high and low affinity forms that can be regulated by GTP[S] in the absence of ligand

Journal of Receptor and Signal Transduction Research

Volumn 16, Issue 1-2, 1996, Pages 59-75

  Domalewski, Mark D ^b   Guyer, Deborah A ^b   Freer, Richard J ^a   Muthukumaraswamy, Natesa ^a   Sklar, Larry A ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; FORMYLPEPTIDE; GUANOSINE TRIPHOSPHATE; PERTUSSIS TOXIN;

ARTICLE; BINDING SITE; CELL GROWTH; CELL MEMBRANE PERMEABILITY; COUPLING FACTOR; DESENSITIZATION; DRUG RECEPTOR BINDING; ENZYME REGULATION; HUMAN; HUMAN CELL; LIGAND BINDING; NITROGEN FIXATION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION;

EID: 0029952588     PISSN: 10799893     EISSN: None     Source Type: Journal    
DOI: 10.3109/10799899609039941     Document Type: Article

References (33)

1. De Lean, A., J. M. Stadel, and R. J. Lefkowitz. 1980. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor. J. Biol. Chem. 255:7108-7117.
2. Gilman, A. G., 1987. G Proteins:Tranducers of Receptor-Generated Signals. Ann. Rev. Biochem. 56:615-649.
3. Ali, H., R.M. Richardson, E.D. Tonhave, J.R. Didsbury and R. Snyderman. 1993. Differences in phosphorylation of formyl peptide and C5a chemoattractant receptors correlate with differences in desensitization. J. Biol. Chem. 268(32)24247-242454.
4. Sklar, L.A. 1986. Ligand-Receptor Dynamics and Signal Amplification in the Neutrophil. Advances in Immunology (F.J. Dixon, ed.) 39:95-143.
5. Mueller, H., R. Weingarten, L. Ransas, G. M. Bokoch, and L. A. Sklar. 1991. Differential amplification of antagonistic receptor pathways in neutrophils.. J. Biol. Chem. 266:12939-12943.
6. Wymann, M.P., V. Tscharner, D.A Deranleau, and M. Baggioloini. 1987. The onset of the respiratory burst in human neutrophils. J. Bio. Chem. 262:12048-12053.
7. Wilde, M. W., K. E. Carlson, D. R. Manning, and S. H. Zigmond. 1989. Chemoattractant stimulated GTPase activity is decreased on membranes from polymorphonuclear leukocytes incubated in chemoattractant. J. Biol. Chem. 264:190-196.
8. 2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein. J. Biol. Chem. 262:4860-4867.
9. Williamson, K., B. F. Dickey, H. Y. Pyun, and J. Navarro. 1988. Solubilization and reconstitution of the formyl-methionylleucylphenylalanine receptor coupled to guanine nucleotide regulatory protein. Biochem. 27:5371-5377.
10. 1 Adenosine Receptor. J. Biol. Chem. 260:6728-6732.
11. Posner, R. P., S. P. Fay, M. D. Domalewski, and L. A. Sklar. 1994. Continuous spectrofluorometric analysis of formyl peptide receptor ternary complex interactions. Mol. Pharm. 45:65-73.
12. 2 Adrenergic Receptors: Evidence for a Precoupled Receptor-Guanine Nucleotide Protein Complex. Biochemistry 27:2374-2384.
13. Fay, S. P., R. P. Posner, W. N. Swann, and L. A. Sklar. 1991. Real-Time Analysis of the assembly of Ligand, Receptor, and G-Protein by Quantitative Fluorescence Flow Cytometry. Biochemistry 30:5066-5075.
14. Wreggett, K.A. and A. DeLean. 1984. The ternary complex model. Its properties and application to ligand interactions with the D2-dopamine receptor of the anterior pituitary gland. Mol. Pharm. 26:214-227.
15. 2-Adrenergic Receptors by Sodium. J. Biol. Chem. 265:21590-21595.
16. +, 5′-Guanylylimidodiphosphate, Amiloride and Ethylisopropylamiloride: Evidence for Receptor G-protein Precoupling. J. Pharm. and Exper. Therap. 252:1184-1196.
17. Sklar, L.A., Bokoch, G.M., Button, D., andSmolen, J.E. 1987. Regulation of Ligand-Receptor Dynamics by Guanine Nucleotides. J. Biol. Chem. 262:135-139.
18. o linked receptors and its allosteric regulation by monovalent cations. Life Sciences 52:1899-1907.
19. i-proteins mediate formyl peptide receptor signal transduction in human leukemia (HL-60) cells. J. Biol. Chem. 264:21470-21473.
20. Oinuma, M., T. Katada, and M. Ui. 1986. A new GTP-binding protein in differentiated human leukemic (HL-60) cells serving as the specific substrate of islet-activating protein, pertussis toxin. J. Biol. Chem. 252:8347-8353.
21. Tolley, J. O., G. M. Omann, and A. J. Jesaitis. 1987. A High-Yield, High Purity Elutriation Method for Preparing Human Granulocytes Demonstrating Enhanced Experimental Lifetimes. J. Leukocyte Biol. 42:43-50.
22. Parkos, C.A., R.A. Allen, C.G. Cochrane, and A.J. Jesaitis. 1987. Purified cytochrome b from human granulocyte plasma membrane is composed of two polypeptides with relative molecular weights of 91000 and 22000. J. Clin. Invest. 80:732-742.
23. Muthukumaraswamy, N., andFreer, R.J. 1987. Methods Enzymol., Synthesis of chemotactic peptides. 162:3860-3874.
24. Sklar, L. A., Z. G. Oades, A. J. Jesaitis, R. G. Painter, and C. G. Cochrane. 1981. Fluoresceinated chemotactic peptide and high affinity antifluorescein antibody as a probe of neutrophil stimulation. Proc. Nat. Acad. Sci. 78:7540-7544.
25. Levison, S. A., A. N. Hicks, A. J. Portman, and W. B. Dandliker. 1975. Equilibrium binding studies on antifluorescein antibody during various stages of the immune response. Biochem. 74:3778-3786.
26. Sklar, L. A., S.P. Fay, B.E. Seligmann, R.J. Freer, N. Muthukumaraswamy, and H. Mueller. 1990. Fluorescence analysis of the size of a binding pocket of a peptide receptor at natural abundance. Biochemistry. 29:313-316
27. Sklar, L.A., Finney, D.A., Oades, Z.G., Jesaitis, A.J., Painter, R.G., andCochrane, C.G. 1984. Dynamics of ligand receptor interactions. Real time cytometric and fluorometric assays of association, dissociation, and internalization of an N-formyl peptide and its receptors on human neutrophils. J. Biol. Chem. 259:5661-5669.
28. Dratz, E. A., J. E. Furstenau, C. G. Lambert, D. L. Thireault, H. Rarick, T. Schepers, S. Pakhlevaniants, and H. E. Hamm. 1993. NMR structure of a receptor-bound G-protein peptide. Nature. 363:276-280.
29. Neubig, R.R., 1994. Membrane organization in G protein mechanisms. FASEB J. 8:939-946.
30. 2 adrenergic receptor. Extending the ternary complex model. J. Biol. Chem. 268:4625-4636.
31. Eberle, M., A. E. Traynor-Kaplan, L. A. Sklar, and J. Norgauer. 1990. Is there a relationship between PIP3 and F-Actin Polymerization in Human Neutrophils? J. Biol. Chem. 255:16725-16728.
32. ++. Journal of Cell Biology 707:1161-1166.
33. Richard R. Neubig and Larry A. Sklar. 1993. Subsecond Modulation of Formyl Peptide-Linked Guanine Nucleotide-Binding Proteins by Guanosine 5′-O-(3-Thio)triphosphate in Permeabilized Neutrophils. Mol. Pharm. 43:734-740.