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For a recent example of cytochalasin B as a probe of the galactose/H+ transporter in E.Coli see: Cairns, M. T.; McDonald, T. P.; Horne, P.; Henderson, P. J. F; Baldwin, S. A. J. Biol. Chem. 1991, 266, 8176-8183.
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85030200257
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note
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Further manipulations to produce functionalities present in the natural product but lacking the macrocyclic ring were achieved using procedures described in the literature. For example see reference 10b.
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42
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85030204472
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Advanced ACS Abstracts August 1993
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None of the intermediates shown or analogs which lack the macrocyclic ring were active in the enzyme inhibition assay. Portions of that work has been published in: Advanced ACS Abstracts August 1993.
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