Activated protein C resistance: A comparison between two clotting assays and their relationship to the presence of the factor V Leiden mutation

British Journal of Haematology

Volumn 93, Issue 3, 1996, Pages 694-699

  Legnani, C ^a   Palareti, G ^a   Biagi, R ^a   Coccheri, S ^a   Bernardi, F ^b   Rosendaal, F R ^c   Reitsma, P H ^c   De Ronde, H ^c   Bertina, R M ^c  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

APC resistance; Factor V Leiden mutation; Thrombophilia

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 5 LEIDEN;

ACTIVATED PROTEIN C RESISTANCE; ADOLESCENT; ADULT; AGED; ARTICLE; ASSAY; BLOOD CLOTTING; COMPARATIVE STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; THROMBOPHILIA;

EID: 0029951942     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.d01-1709.x     Document Type: Article

References (26)

1. Alhenc-Gelas, M., Gandrille, S., Aubry, M.L., Emmerich, J., Fiessinger, J.N. & Aiach, M. (1994) Unexplained thrombosis and factor V Leiden mutation. Lancet, 344, 555-556.
2. Baker, R., Thom, J. & van Bockxmeer, F. (1994) Diagnosis of activated protein C resistance (factor V Leiden). Lancet, 344, 1162.
3. Beauchamp, N.J., Daly, M.E., Hampton, K.K., Cooper, P.C., Preston, F.E. & Peake, I.R. (1994) High prevalence of a mutation in the factor V gene within the U.K. population: relationship to activated protein C resistance and familial thrombosis. British Journal of Haematology, 88, 219-222.
4. Bertina, R.M., Koeleman, B.P.C., Koster, T., Rosendaal, F.R., Dirven, R.J., de Ronde, H., van der Velden, P.A. & Reitsma, P.H. (1994) Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature, 369, 64-67.
5. Bertina, R.M., Reitsma, P.H., Rosendaal, F.R. & Vandenbroucke, J.P. (1995) Resistance to activated protein C and factor V Leiden as risk factors for venous thrombosis. Thrombosis and Haemostasis, 74, 449-453.
6. Cadroy, Y., Sie, P. & Boneu, B. (1994) Frequency of a defective response to activated protein C in patients with history of venous thrombosis. Blood, 83, 2008-2009.
7. Choi, B.C.K. (1992) Sensitivity and specificity of a single diagnostic test in the presence of work-up bias. Journal of Clinical Epidemiology, 45, 581-586.
8. Cook, G., Walker, I.D., McCall, F., Conkie, J.A. & Greer, I.A. (1994) Familial thrombophilia and activated protein C resistance: thrombotic risk in pregnancy? British Journal of Haematology, 87, 873-875.
9. Cushman, M., Bhushan, F., Bovill, E. & Tracy, R. (1994) Plasma resistance to activated protein C in venous and arterial thrombosis. Thrombosis and Haemostasis, 72, 643-651.
10. Dahlbäck, B., Carlsson, M. & Svensson, P.J. (1993) Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proceedings of the National Academy of Sciences of the United States of America, 90, 1004-1008.
11. Dahlbäck, B. & Hildebrand, B. (1994) Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a properties of factor V. Proceedings of the National Academy of Sciences of the United States of America, 91, 1396-1400.
12. de Ronde, H. & Bertina, R.M. (1994) Laboratory diagnosis of APC-resistance: a critical evaluation of the test and the development of diagnostic criteria. Thrombosis and Haemostasis, 72, 880-886.
13. Faioni, E.M., Franchi, F., Asti, D., Sacchi, E., Bernardi, F. & Mannucci, P.M. (1993) Resistance to activated protein C in nine thrombophilic families: interference in a protein S functional assay. Thrombosis and Haemostasis, 70, 1067-1071.
14. Griffin, J.H., Evat, B., Wideman, C. & Fernandez, J.A. (1993) Anticoagulant protein C pathway defective in majority of thrombophilic patients. Blood, 82, 1989-1993.
15. Halbmayer, W.M., Haushofer, A., Schön, R. & Fischer, M. (1994) Prevalence of poor anticoagulant response to activated protein C (APC resistance) among patients suffering from stroke or venous thrombosis and among healthy subjects. Blood Coagulation and Fibrinolysis, 5, 51-57.
16. Jorquera, J.I., Montoro, J.M., Fernandez, M.A., Aznar, J.A. & Aznar, J. (1994) Modified test for activated APC resistance. Lancet, 344, 1162-1163.
17. Koster, T., Rosendaal, F.R., de Ronde, H., Briët, E., Vandenbroucke, J.P. & Bertina, R.M. (1993) Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet, 342, 1503-1506.
18. Legnani, C., Palareti, G., Biagi, R. & Coccheri, S. (1994) Activated protein C resistance in deep-vein thrombosis. Lancet, 343, 541-542.
19. Ransohoff, D.F. & Feinstein, A.R. (1978) Problems of spectrum and bias in evaluating the efficacy of diagnostic tests. New England Journal of Medicine, 17, 926-930.
20. Rosen, S., Johansson, K., Lindberg, K. & Dahlbäck, B., for the APC Resistance Study Group (1994) Multicentric evaluation of a kit for activated protein C resistance on various coagulation instruments using plasmas from healthy individuals. Thrombosis and Haemostasis, 72, 255-260.
21. Rosendaal, F.R., Koster, T., Vandenbroucke, J.P. & Reitsma, P.H. (1995) High risk of thrombosis in patients homozygous for factor V Leiden. Blood, 85, 1504-1508.
22. Svensson, P.J. & Dahlbäck, B. (1994) Resistance to activated protein C as a basis for venous thrombosis. New England Journal of Medicine, 330, 517-522.
23. Trossaert, M., Conard, J., Horellou, M.H., Samama, M.M., Ireland, H., Bayston, T.A. & Lane, D.A. (1994) Modified APC resistance assay for patients on oral anticoagulants. Lancet, 344, 1709.
24. Vandenbroucke, J.P., Koster, T., Briët, E., Reitsma, P.H., Bertina, R.M. & Rosendaal, F.R. (1994) Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation. Lancet, 344, 1453-1457.
25. Voorberg, J., Roelse, J., Koopman, R., Büller, H., Berends, F., ten Cate, J.W., Mertens, K. & van Mourik, J.A. (1994) Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V. Lancet, 343, 1535-1536.
26. Zöller, B., Svensson, P.J., He, X. & Dahlbäck, B. (1994) Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C. Journal of Clinical Investigation, 94, 2521-2524.