A novel endotoxin antagonist attenuates tumor necrosis factor-α secretion

Journal of Surgical Research

Volumn 63, Issue 1, 1996, Pages 44-48

  Dahlberg, Peter S ^a   Acton, Robert D ^a   Battafarano, Richard J ^a   Uknis, Marc E ^a   Ratz, Craig A ^a   Johnston, Jennifer W ^a   Haseman, Judith R ^b   Gray, Beulah H ^b   Dunn, David L ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERICIDAL PERMEABILITY INCREASING PROTEIN; ESCHERICHIA COLI ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; KEYHOLE LIMPET HEMOCYANIN; PEPTIDE BG 38; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; CONFERENCE PAPER; CONJUGATION; CONTROLLED STUDY; ESCHERICHIA COLI; MACROPHAGE; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; SEPSIS;

EID: 0029951814     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0220     Document Type: Conference Paper

References (14)

1. Tracey, K. J., and Lowry, S. F. The role of cytokine mediators in septic shock. Adv. Surg. 23: 21-56, 1990.
2. McCabe, W. R., Kreger, B. E., and Johns, M. Type-specific and cross-reactive antibodies in gram-negative bacteremia. N. Engl. J. Med. 287: 261-267, 1972.
3. Bone, R. C. A critical evaluation of new agents for the treatment of sepsis. JAMA 266: 1686-1691, 1991.
4. Weiss, J., Elsbach, P., Olsson, I., and Odeberg, H. Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes. J. Biol. Chem. 253: 2664-2672, 1978.
5. Hovde, C. J., and Gray, B. H. Physiological effects of a bactericidal protein from human polymorphonuclear leukocytes on Pseudomonas aeruginosa. Infect. Immun. 52: 90-95, 1986.
6. Wasiluk, K. R., Skubitz, K. M., and Gray, B. H. Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa. Infect. Immun. 59: 4193-4200, 1991.
7. Gray, B. H., and Haseman, J. R. Bactericidal activity of synthetic peptides based on the structure of the 55-kilodalton bactericidal protein from human neutrophils. Infect. Immun. 53: 595-623, 1994.
8. Jin, H., Yang, R., Marsters, S., Ashkenazi, A., Bunting, S., Marra, M. N., Scott, R. W., and Baker, B. J. Protection against endotoxic shock by bactericidal/permeability-increasing protein in rats. J. Clin. Invest. 95: 1947-1952, 1995.
9. Kelly, C. J., Cech, A. C., Argenteanu, M., Gallagher, H., Shou, J., Minnard, E., and Daly, J. M. Role of bactericidal permeability-increasing protein in the treatment of gram-negative pneumonia. Surgery 114: 140-746, 1993.
10. Evans, T. J., Carpenter, A., Moyes, D., Martin, R., and Cohen, J. Protective effects of a recombinant amino-terminal fragment of human bactericidal/permeability-increasing protein in an animal model of gram-negative sepsis. J. Infect. Dis. 171: 153-160, 1995.
11. Hoess, A., Watson, S., Siber, G. R., and Liddington, R. Crystal structure of an endotoxin-neutralizing protein from the horseshoe crab, Limulus anti-LPS factor, at 1.5 Å resolution. EMBO J. 12: 3351-3356, 1993.
12. Battafarano, R. J., Dahlberg, P. S., Ratz, C. A., Johnston, J. W., Gray, B. H., Haseman, J. R., Mayo, K. H., and Dunn, D. L. Peptide derivatives of three distinct lipopolysaccharide binding proteins inhibit lipopolysaccharide-induced tumor necrosis factor-alpha secretion in vitro. Surgery 118: 318-324, 1995.
13. Gregersen, J. P., Mehdi, S., Gelderblom, H., and Zettmeibl, G. A CD4: Immunoglobulin fusion protein with antiviral effects against HIV. Arch. Virol. 111: 29-43, 1990.
14. Ashkenazi, A., Marsters, S. A., Capon, D. J., Chamow, S. M., Figari, I. S., Pennica, D., Goeddel, D. V., Palladino, M. A., and Smith, D. H. Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesion. Proc. Natl. Acad. Sci. 88: 10535-10539, 1991.