Decrease of ciliary beat frequency by platelet activating factor: Protective effect of ketotifen

Inflammation Research

Volumn 45, Issue 5, 1996, Pages 234-238

  Kahhak, L ^a   Roche, A ^b   Dubray, C ^b   Arnoux, C ^a   Benveniste, J ^a  

^a INSERM   (France)

^b Laboratoires Sandoz   (France)

Author keywords

Anti histamine; Ciliary beat frequency; Ketotifen; PAF antagonist; Platelet activating factor

Indexed keywords

ANTIASTHMATIC AGENT; ANTIHISTAMINIC AGENT; APAFANT; KETOTIFEN FUMARATE; LYSOPHOSPHATIDYLCHOLINE; THROMBOCYTE ACTIVATING FACTOR; TRIPELENNAMINE;

ANIMAL TISSUE; ARTICLE; CILIARY MOTILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GUINEA PIG; LUNG CLEARANCE; MUCOCILIARY TRANSPORT; NONHUMAN; STATISTICAL ANALYSIS; TRACHEA; TRACHEA MUCOSA;

ANIMALS; AZEPINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HISTAMINE H1 ANTAGONISTS; KETOTIFEN; MUCOCILIARY CLEARANCE; PLATELET ACTIVATING FACTOR; PLATELET AGGREGATION INHIBITORS; TRACHEA; TRIAZOLES;

EID: 0029951567     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02259609     Document Type: Article

References (36)

1. Lucas A, Douglas LC. Principles underlying ciliary activity in the respiratory tract. Otolaryngol 1934;20:518-41.
2. Hiding AC. Ciliary streaming in the lower respiratory tract. Am J Pathol 1957;191:404-10.
3. Sturges JM. Mucociliary clearance and mucous secretion in the Lung. In: Witschi HP, Brain JD, editors. Toxicology of Inhaled Materials. Berlin: Springer-Verlag, 1985:319-67.
4. Seybold ZV, Mariassy AT, Stroh D, Kim CS, Gazeroglu H, Wanner A. Mucociliary interaction in vitro: effects of physiological and inflammatory stimuli. J Appl Physiol 1990;68: 1421-6.
5. Laitinen LA, Heino A, Laitinen T, Kava T, Haahtela T. Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Resp Dis 1985;131:599-606.
6. Dulfano MJ, Luck CK, Beckage M, Woolen O. Ciliary inhibitory effects of asthma patients sputum. Clin Sci 1982;63:393-6.
7. Benveniste J, Henson PM, Cochrane CG. Leukocyte-dependent histamine release from rabbit platelets: The role of IgE, basophils and a platelet-activating factor. J Exp Med 1972; 136:1356-77.
8. Benveniste J. Paf-acether, an ether phospholipid with biological activity. Proc Clin Biol Res 1988;282:73.
9. Arnoux B, Joseph M, Simöes MH, Tonnel AB, Duroux P, Capron A, et al. Antigenic release of paf-acether and b-glucuronidase from alveolar macrophages of asthmatics. Bull Eur Physiopathol Resp 1987;23:119-24.
10. Hopp RJ, Bewta AK, Agrawal DK, Townley RG. Effect of platelet-activating factor inhalation on nonspecific bronchial hyperreactivity in man. Chest 1989;96:1070-2.
11. Goswami SK, Ohashi M, Stathas P, Marom ZM. Platelet-activating factor stimulates secretion of respiratory glycoconjugate from human airways in culture. J Allergy Clin Immunol 1989;84:726-34.
12. Martin U, Römer D. The pharmacological properties of a new, orally active anti-anaphylacetic compound: Ketotifen, a benzocyclo-heptathiophene. Arzneim Forsch/Drug Res 1978; 28:770-82.
13. Arnoux B, Denjean A, Page CP, Nobile D, Morley J, Benveniste J. Accumulation of platelets and eosinophils in baboon lung after paf-acether challenge. (Inhibition by ketotifen). Am Rev Respir Dis 1988;137:855-60.
14. Devillier P, Arnoux B, Lalau Keraly C, Landes A, Marsac J, Benveniste J. Inhibition of human and rabbit platelet activation by ketotifen. Fundam Clin Pharmacol 1990;4:1-9.
15. Chevance LG, Lennon JF. Etude des rythmes des battements ciliaires. Acta Otolaryngol 1970;70:16-29.
16. Ganbo T, Hisamatsu K. Mucosal dysfunction and damage induced by platelet-activating factor (PAF). Acta Otolaryngol 1990;110:427-36.
17. Nieminen MM, Moilanen EK, Nyhlolm JEJ, Koshinen MO, Karvonen JI, Metsä-Keteldä TJ. et al. Platelet-activating factor impairs mucociliary transport and increases leucotriene B4 in man. Eur Respir J 1991;4:551-60.
18. Yukawa Y, Read RC, Kroegel C, Rutman A, Chung KF, Wilson R, et al. The effects of activated eosinophils and neutrophils on guinea-pig airway epithelium in vitro. Am J Respir Cell Mol Biol 1990;2:341-53.
19. Sturgess JM, Czegledy-Nagy E. Mucus-secretion in the lung. In: Johari O, editor. Scanning electron microscopy II. SEM Inc, AMF O'Hare, 1978:1083-6.
20. Muirhead EE, Byers LW, Desiderio D, Mith KA, Prewitt RL, Brooks B. Alkyl ether analogs of phosphatidylcholine are orally active in hypertensive rabbits. Hypertension 198;3: 107-11.
21. Hwang SB, Lam MH, Shen TY. Specific binding sites for platelet activating factor in human lung tissues. Biochem Biophys Res Commun 1985;128:972-9.
22. Hunda RK, Strandhoy JW, Buckalew VM. Vasorelaxant effect of C16-paf and C18-paf on renal blood flow and systemic blood pressure in the anesthetized rat. Life Sci 1991;49:747-52.
23. Haroldsen PE, Voelkel NF, Henson JE, Henson PM, Murphy RC. Metabolism of platelet-activating factor in isolated perfused rat lung. J Clin Invest 1987;1860-7.
24. Kumar R, King RJ, Martin HM, Hanahan DJ. Metabolism of platelet-activating factor (alkylacetylphosphorylcholine) by type-II epithelial cells and fibroblasts from rat lungs. Biochim Biophys Acta 1987;917:33-41.
25. Arnoux B, Duval D, Benveniste J. Release of platelet-activating factor (PAF-acether) from alveolar macrophage by the calcium ionophorc A23187 and phagocytosisvest. Eur J Clin Invest 1980;10:437-41.
26. Mac-Donald GF, Ackerman F, Plumbley OL, editors. A double-blind study to clinically evaluate Ketotifen in the treatment of bronchial asthma. Proceedings of the symposium on Ketotifen. Recent advances in the treatment of asthma. Amsterdam: Excerpta Medica, 1988:47-57.
27. Okuda M. Clinical investigation of ketotifen in perennial allergic rhinitis: a double-blind comparative study of ketotifen and clemastine fumarate. Rhinology 1984;22:171-82.
28. Denjean A, Arnoux B, Masse R, Lockhart A, Benveniste J. Acute effect of intratracheal administration of platelet-activating factor in baboons. J Appl Physiol 1983;55:799-804.
29. Hoshiko K, Kristerson A, Morley J. Ketotifen inhibits exacerbation of allergic hyperreactivity by racemic salbutamol in the guinea pig. J Allergy Clin Immunol 1993;91:909-16.
30. Iwama T, Nagai H, Tsuruoka N, Koda A. Effect of murine recombinant interleukin-5 on bronchial reactivity in guinea pig. Clin Exp Allergy 1993;23:32-8.
31. Howel RE, Sickels BD, Weichman BM. Comparison of the airway hyperreactivity produced by single and multiple antigen exposures in sensitized guinea pig. Agents Actions 1992;37: 195-7.
32. Koshino T, Agrawal DK, Townley TA, Townley RG. Ketotifen prevents terbutaline-induced down-regulation of beta-adrenoceptors in guinea-pig lung. Biochem Biophys Res Commun 1988;2:1221-7.
33. Brodde OE, Howe U, Egersszegi S, Konietzko N, Michel MC. Effect of prednisolone and ketotifen on beta2-adrenoceptors in asthmatic patients receiving beta2-bronchodilators. Eur J Clin Pharmacol 1988;34:145-50.
34. Chand N, Pillar J, Diamantis W, Sofia RD. Inhibition of allergic histamine release by azelastine and selected anti-allergic drugs from rabbit leukocytes. Int Arch Allergy Appl Immunol 1985;77:451-5.
35. Cuss FM, Dixon CMS, Barnes PJ. Effects of inhaled platelet-activating factor on pulmonary function and bronchial responsiveness in man. Lancet 1986:ii:189-92.
36. O'Donnell SR, Barnett CJ. Microvascular leakage to platelet activating factor in guinea-pig trachea and bronchi. Eur J Pharmacol Physiol 1987;138:385-96.