Effects of furosemide on hemorheologic alterations induced by incremental treadmill exercise in Thoroughbreds

American Journal of Veterinary Research

Volumn 57, Issue 6, 1996, Pages 891-895

  Weiss, Douglas J ^a   Geor, Raymond J ^a,b   Burger, Katherina ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FUROSEMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; BLOOD RHEOLOGY; CONTROLLED STUDY; ELECTROLYTE BLOOD LEVEL; ERYTHROCYTE; HORSE; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; TREADMILL EXERCISE;

ANIMALS; BLOOD PROTEINS; BLOOD VISCOSITY; CHLORIDES; DIURETICS; ELECTROLYTES; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; FEMALE; FUROSEMIDE; HEMATOCRIT; HEMODYNAMIC PROCESSES; HORSES; MALE; OSMOSIS; PHYSICAL CONDITIONING, ANIMAL; POTASSIUM; RHEOLOGY; WATER-ELECTROLYTE BALANCE;

EID: 0029951365     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Tobin T, Roberts BL, Swerczek TW, et al. The pharmacology of furosemide in the horse. III. Dose and time response relationship, effects of repeated dosing, and performance effects. Compend Contin Educ Pract Vet 1978;2:216-226.
2. Hinchcliff KW, Muir WW. Pharmacology of furosemide in the horse: a review. J Vet Intern Med 1991;5:211-218.
3. Pascoe JR, McCabe AE, Franti CE, et al. Efficacy of furosemide in the treatment of exercise-induced pulmonary hemorrhage in Thoroughbred racehorses. Am J Vet Res 1985;46:2000-2003.
4. Manohar M, Hutchens E, Coney E. Furosemide attenuates the exercise-induced rise in pulmonary capillary blood pressure in horses. Equine Vet J 1994;26:51-54.
5. Erickson BK, Erickson HH, Coffman JR. Pulmonary artery and aortic pressure changes during high intensity treadmill exercise in the horse: effects of furosemide and phentolamine. Equine Vet J 1992;24:215-220.
6. West JB, Mathieu-Costello O, Jones JH, et al. Stress failure of pulmonary capillaries in racehorses with exercise-induced pulmonary hemorrhage. J Appl Physiol 1993;75:1097-1109.
7. Manohar M. Pulmonary artery wedge pressure increases with high-intensity exercise in horses. Am J Vet Res 1993;54:142-146.
8. Fu Z, Costello ML, Tsukimoto K. High lung volume increases stress failure in pulmonary capillaries. J Appl Physiol 1992; 73:123-133.
9. Tsukimoto K, Mathieu-Costello O, Orediletto R. Ultrastructural appearance of pulmonary capillaries at high transmural pressures. J Appl Physiol 1991;71:573-582.
10. Jones JH, Smith EK, Birks JR, et al. Left atrial and pulmonary artery pressures in exercising horses. FASEB J 1992;6:A2020.
11. Fedde MR, Ho HH, Woods SC. Oxygen transport in exercising horses: importance of rheological properties of blood. In: Eduardo J, Bicudo PW, eds. The vertebrate gas transport cascade: adaptations to environment and mode of life. London: CRC Press, 1993;200-207.
12. McClay CB, Weiss DJ, Smith CM, et al. Evaluation of hemorheologic variables as implications for exercise-induced pulmonary hemorrhage in racing Thoroughbreds. Am J Vet Res 1992;53: 1380-1385.
13. Andrews FM, Korenek NL, Sanders WL, et al. Viscosity and rheologic properties of blood from clinically normal horses. Am J Vet Res 1992;53:966-970.
14. Coyne CP, Carlson GP, Spensley MS, et al. Preliminary investigation of alterations in blood viscosity, cellular composition, and electrophoresis of plasma protein fraction profile after competitive racing activity in Thoroughbred horses. Am J Vet Res 1990;51: 1956-1963.
15. Smith JE, Erickson HH, Debowes RM. Changes in circulating equine erythrocytes induced by brief, high-speed exercise. Equine Vet J 1989;21:444-446.
16. Geor RJ, Weiss DJ, Smith CM II. Hemorheologic alterations induced by incremental treadmill exercise in Thoroughbreds. Am J Vet Res 1994;55:854-861.
17. Weiss DJ, Evanson O, Geor RJ. Filterability of equine erythrocytes and whole blood: effects of haematocrit, pore size, and flow rate. Comp Haematol Int 1994;4:11-16.
18. Davis JL, Manohar M. Effects of splenectomy on exercise-induced pulmonary and systemic hypertension in ponies. Am J Vet Res 1988;49:1169-1172.
19. Geor RJ, Weiss DJ, Burris SM, et al. Effects of furosemide and pentoxifylline on blood flow properties in horses. Am J Vet Res 1992;53:2043-2049.
20. Weiss DJ, Evanson OA, Geor RJ. The effects of furosemide and pentoxifylline on the flow properties of equine erythrocytes: in vitro studies. Vet Res Commun 1994;18:373-381.
21. Bull BS, Chein S, Dormandy J, et al. International committee for standardization in haematology. Guidelines for measurements of blood viscosity and erythrocyte deformability. Clin Hemorheof 1986;6:439-453.
22. Conrash LM. Density dependent red cell separation. In: Buetler E, ed. Methods in hematology. New York: Churchill Livingstone, 1986;90-107.
23. Steel RGD, Torrie JH. Principles and procedures of statistics: a biometrical approach New York: McGraw-Hill Book Co. 1980;377-397.
24. Hinchcliff KW, Mitten LA. Furosemide, bumetanide, and ethacrynic acid. Vet Clin North Am Equine Pract 1993;9:511-552.
25. Freestone JF, Carlson GP, Harrold DR, et al. Influence of furosemide treatment on fluid and electrolyte balance in horses. Am J Vet Res 1988;49:1899-1902.
26. Stuart J, Nash GB. Red cell deformability and haematologic disorders. Blood Rev 1990;32:141-147.
27. Somer EA, Meiselman HJ. Disorders of blood viscosity. Ann Med 1993;25:31-392.
28. Ihrig I, Schnheit C, Haubner W, et al. Characterization of the potassium influx in rat erythrocytes. Gen Physiol Biopliys 1992; 11:377-388.
29. Burkowitz LE. Loop diuretics and anion modification of NEM-induced K transport in human red blood cells. Am J Physiol 1990;258:C622-C629.
30. Gibson JS, Ellory JC, Culliford SJ, et al. Volume-sensitive KCl co-transport and taurine fluxes in horse red blood cells. Exp Physiol 1993;78:685-695.
31. McKelvie RS, Lindinger MI, Heigenhauser GJF, et al. Contribution of erythrocytes to the control of the electrolyte changes of exercise. Can J Physiol Pharmacol 1991;69:984-993.
32. Buono MJ, Faucher PE. Intraerythrocyte and plasma osmolality during graded exercise in humans. J Appl Physiol 1985;58: 1069-1072.