Pharmacokinetics of the individual enantiomers of vigabatrin in neonates with uncontrolled seizures

British Journal of Clinical Pharmacology

Volumn 42, Issue 6, 1996, Pages 779-781

  Vauzelle Kervroedan F ^a,b   Rey, E ^a   Pons, G ^a   D'Athis, Ph ^a   Chiron, C ^b   Dulac, O ^b   Dumas, C ^c   Olive, G ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b HÔPITAL SAINT VINCENT DE PAUL   (France)

^c Marion Merrell SA   (France)

Author keywords

enantiomers; neonates; pharmacokinetics; seizures; vigabatrin

Indexed keywords

CARBAMAZEPINE; PHENOBARBITAL; PHENYTOIN; VALPROIC ACID; VIGABATRIN;

AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; DRUG BLOOD LEVEL; ENANTIOMER; HUMAN; NEWBORN; NEWBORN DISEASE; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; SEIZURE;

EID: 0029951284     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1996.00495.x     Document Type: Article

References (8)

1. Metcalf BW. Inhibitors of GABA metabolism. Biochem Pharmacol 1979, 28: 1705-1712.
2. Grove J, Tell G, Schechter PJ, et al. Increased CSF γ-aminobutyric acid after treatment with γ vinyl GABA. Lancet 1980; ii: 647.
3. Grove J, Schechter PJ, Tell G, et al. Increased gamma-amino-butyric acid (GABA), homocarnosine and β alanine in cerebrospinal fluid of patients treated with γ vinyl GABA (4-amino-hex-5-enoic acid). Life Sci 1981; 28: 2431-2439.
4. Gram L. Vigabatrin In Comprehensive Epileptology ed Dam M, Gram L, Raven Press New York, 1990, 631-640.
5. Haegele KD, Schechter PJ Kinetics of the enantiomers of vigabatrin after an oral dose of the racemate or the active S-enantiomer. Clin Pharmacol Ther 1986; 40: 581-586.
6. Rey E, Pons G, Richard MO, et al. Pharmacokinetics of the individual enantiomers of vigabatrin (γ-vinyl GABA) in epileptic children. Br J Clin Pharmacol 1990; 30: 253-257.
7. Gibaldi M. Biopharmaceutics and Clinical Pharmacokinetics, 2nd edition. Philadelphia: Lea and Febger, 1977.
8. 14C] vigabatrin in healthy male volunteers. Drug Metab Dispos 1993; 21: 480-484.