Recombinant human insulin-like growth factor I, recombinant human growth hormone, and sex steroids: Effects on markers of bone turnover in humans

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 6, 1996, Pages 2222-2226

  Mauras, Nelly ^a   Doi, Sonia Q ^b   Shapiro, Jay R ^b  

^a NEMOURS CHILDREN S CLINIC   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; DEOXYPYRIDINOLINE; ESTROGEN; RECOMBINANT GROWTH HORMONE; RECOMBINANT SOMATOMEDIN C; SEX HORMONE; TESTOSTERONE ENANTATE;

ADULT; ARTICLE; BONE DEVELOPMENT; BONE GROWTH; BONE MASS; BONE TURNOVER; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; HORMONAL REGULATION; HORMONE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; PREPUBERTY; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; TURNER SYNDROME;

ADULT; AMINO ACIDS; ESTROGENS; FEMALE; GONADAL STEROID HORMONES; GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; OSTEOCALCIN; PEPTIDE FRAGMENTS; PROCOLLAGEN; RECOMBINANT PROTEINS; TESTOSTERONE;

EID: 0029950963     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.6.2222     Document Type: Article

References (45)

1. Canalis E, McCarthy T, Centrella M. 1988 Growth factors and the regulation of bone remodeling. J Clin Invest. 81:277-281.
2. McCarthy TL, Centrella M, Canalis E. 1989 Insulin-like growth factor (IGF) and bone. Connect Tissue Res. 20:277-282.
3. McCarthy TL, Centrella M., Canalis E. 1989 Regulatory effects of Insulin-like growth factors I and II on bone collagen synthesis in rat calvarial cultures. Endocrinology. 124:301-309.
4. Mauras N, Haymond MW, Darmaun D, Vieira NE, Abrams SA, Yergey AL. 1994 Calcium and protein kinetics in prepubertal boys: positive effects of testosterone. J Clin Invest. 93:1014-1019.
5. Arisaka O, Arisaka M, Nakayama Y, Fujiwara S, Yabuta K. 1995 Effect of testosterone on bone density and bone metabolism in adolescent male hypogonadism. Metabolism. 44:419-423.
6. Riggs BL, Melton LJ (eds.). 1988 Osteoporosis: etiology, diagnosis and management. New York: Raven Press; 95-109.
7. Risteli L, Risteli J. 1990 Noninvasive methods for detection of organ fibrosis. In: Rojkind M, ed. Connective tissue in health and disease. Boca Raton: CRC Press; 61-98.
8. Parfitt AM, Simon LS, Villanueva AR, Krane SM. 1987 Procollagen type I carboxy-terminal extension peptide in serum as a marker of collagen biosynthesis in bone. Correlation with iliac bone formation rates and comparison with total alkaline phosphatase. J Bone Miner Res. 2:427-436.
9. Hassager C, Jensen LT, Johansen JS, et al. 1991 The carboxy-terminal propeptide of type I procollagen in serum as a marker of bone formation: the effect of nandrolone decanoate and female sex hormones. Metabolism. 40:205-208.
10. Eriksen EF, Charles P, Meisen F, Mosekilde L, Risteli L, Risteli J. 1993 Serum markers of type I collagen formation and degradation in metabolic bone disease: correlation with bone histomorphometry. J Bone Miner Res. 8:127-132.
11. Saggese G, Bertelloni S, Baroncelli GI, DiNero G. 1992 Serum levels of PICP of type I procollagen in healthy children from first year of life to adulthood and in metabolic bone diseases. Eur J. Pediatric. 151:764-768.
12. Carey DE, Goldberg B, Ratzan SK, Rubin KR, Rowe DW. 1984 RIA for type I procollagen in growth hormone-deficient children before and during treatment with growth hormone. Pediatr Res. 19:8-11.
13. Herrel NT, Stoltenberg M, Juul A, et al. 1993 Serum concentrations of type I and III procollagen propeptides in healthy children and girls with central precocious puberty during treatment with GnRHa and cyproterone acetate. J Clin Endocrinol Metab. 76:924-927.
14. Jonsson KB, Ljunghall S, Karlstrom O, Johansson AG, Mallmin H, Ljunggren O. 1993 Insulin-like growth factor (IGF) enhances the formation of type I collagen in hydrocortisone treated human osteoblasts. Biosci Rep. 13:297-302.
15. Shapiro JR, Rachis R, Bellantoni M, Harman SM, Blackman MR. 1993 The effect of insulin growhth factor I on skeletal turnover in post menopausal women. J Bone Miner Res. 8(Suppl):S327.
16. Price PA, Otsuka AS, Poser JW, Kristaponis J, Raman N. 1976 Characterization of α-carboxy glutamic acid containing protein for bone. Proc Natl Acad Sci USA. 73:1447-1451.
17. Malluche HH, Faugere MC, Fanti P, Price, PA. 1984 Plasma levels of bone Gla-protein reflect bone formation in patients on chronic maintenance dialysis. Kidney Int. 26:869-874.
18. Brown JP, Delmas PD, Malaval L, Edouard C, Chapuy MC, Meunier PJ. 1984 Serum bone Gla-protein: a specific marker for bone formation in postmenopausal osteoporosis. Lancet. 1:1091-1093.
19. Riggs BL, Tsai KS, Mann KG. 1986 Effect of acute increases in bone matrix degradation on circulating levels of bone Gla-protein. J Bone Miner Res. 1:539-542.
20. Ebeling PR, Peterson JM, Riggs BL. 1992 Utility of type I procollagen propeptide assays for assessing abnormalities in metabolic bone diseases. J Bone Miner Res. 7:1243-1250.
21. Eyre D. 1987 Collagen cross-linking amino acids. Methods Enzymol. 144:115-139.
22. Kushida K, Takahashi M, Kawana K, Inoue T. 1995 Comparison of markers for bone formation and resorption in premenopausal and postmenopausal subjects, and osteoporosis patients. J Clin Endocrinol Metab. 80:2447-2450.
23. Seibel MJ, Cosman F, Shen V, et al. 1993 Urinary hydroxypyridinium crosslinks of collagen as markers of bone resorption and estrogen efficacy in postmenopausal osteoporosis. J Bone Miner Res. 8:881-889.
24. Mauras N, Horber FF, Haymond MW. 1992 Low dose recombinant human insulin-like growth factor-I fails to affect protein anabolism but inhibits islet cell secretion in humans. J Clin Endocrinol Metab. 75:1192-1197.
25. Mauras N, Beaufrere B. 1995 Recombinant human insulin-like growth factor-I enhances whole body protein anabolism and significantly diminishes the protein catabolic effects of prednisone in humans without a diabetogenic effect. J Clin Endocrinol Metab. 80:869-874.
26. Mauras N. 1995 Combined recombinant human growth hormone and recombinant human insulin-like growth factor I: lack of synergy on whole body protein anabolism in normally fed subjects. J Clin Endocrinol Metab. 80:2633-2637.
27. Mauras N. 1995 Estrogens do not affect whole body protein metabolism in the prepubertal female. J Clin Endocrinol Metab. 80:2842-2845.
28. Melkko J, Niemi S, Risteli L, Risteli J. 1990 Radioimmunoassay of the carboxy terminal propeptide of human type I procollagen. Clin Chem. 36:1328-1332.
29. Garnero P, Grimaux M, Demiaux B, Preaudat C, Seguin P, Delmas PD. 1992 Measurement of serum osteocalcin with a human-specific two-site immunoradiometric assay. J Bone Miner Res. 7:1389-1398.
30. Delmas PD, Gineyts E, Bertholin A, Garnero P, Marchand F. 1993 Immunoassay of pyrydininoline crosslink excretion in normal adults and in Pagets disease. J Bone Miner Res. 8:643-648.
31. Daughaday WH, Mariz IK, Blethen SL. 1980 Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: a comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid ethanol-extracted serum. J Clin Endocrinol Metab. 51:781-788.
32. Stein GS, Lian JB, Owen TA. 1940 Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation. FASEB J. 4:3111-3123.
33. Mauras N, Vieira N, Yergey AL. 1995 Prepubertal hypogonadism in the female is associated with increased bone turnover: effects of estrogen replacement [Abstract P2-603]. Proc of the 77th Annual Meet of The Endocrine Soc. 1995; 441.
34. Hickman J, McElduff A. 1989 Insulin promotes growth of the cultured rat osteosarcoma cell line UMR-106-01: an osteoblast-like cell. Endocrinology. 124:701-706.
35. Kunkler KJ, Everett LM, Breedlove DK, Kempson SA. 1991 Insulin stimulates sodium-dependent phosphate transport by osteoblast-like cells. Am J Physiol 260:E751-E755.
36. Guler HP, Zapf J, Froesch ER. 1987 Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults. N Engl J Med. 317:137-140.
37. Winster C, Rehn U, Seibel MJ, Erdmann J, Ziegler R. 1994 Effects of rhGH on bone metabolism and bone density in pituitary insufficient patients. Endocrinol Metab 1(Suppl B):0.024.
38. Holloway L, Butterfield G, Hintz RL, Gesundheit N, Marcus R. 1994 Effects of recombinant human growth hormone on metabolic indices, body composition, and bone turnover in healthy elderly women. J Clin Endocrinol Metab. 79:470-479.
39. Lieberman SA, Holloway L, Marcus R, Hoffman AR. 1994 Interactions of growth hormone and parathyroid hormone in renal phosphate, calcium, and calcitriol metabolism and bone remodeling in postmenopausal women. J Bone Miner Res. 9:1723-1728.
40. Machwate M, Zerath E, Holy X, Pastoureau P, Marie PJ. 1994 Insulin-like growth factor-I increase trabecular bone formation and osteoblastic cell proliferation in unloaded rats, Endocrinology. 134:1031-108.
41. Spencer EM, Liu CC, Si EC, Howard GA. 1991 In VRV actions of insulin-like growth factor-I (IIGF-I) on bone formation and resorption in rats. Bone. 12: 21-26.
42. Ammann P, Rizzoli R, Muller K, Slosman D, Bonjour JP. 1943 IGF-I and pamidronate increase bone mineral density in ovariectomized adult rats. Am J Physiol. 265:E770-E776.
43. Grinspoon SK, Baum HBA, Peterson S, Klibanski A. 1995 Effects of rhIGF-I administration on bone turnover during short-term fasting. J Clin Invest. 96:900-906.
44. Horber FF, Haymond MW. 1990 Human growth hormone prevents the protein catabolic side effects of prednisone in humans. J Clin Invest. 86:265-272.
45. Smith EP, Boyd J, Frank GR, et al. 1994 Estrogen resistance caused by a mutation in the estrogen receptor-gene in a man. N Engl J Med 331:1056-1061.