Keenamide A, a bioactive cyclic peptide from the marine mollusk Pleurobranchus forskalii

Journal of Natural Products

Volumn 59, Issue 6, 1996, Pages 629-631

  Wesson, Keena J ^a   Hamann, Mark T ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEXAPEPTIDE;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; MALARIA; MOLECULAR CLONING; MOLLUSC; NONHUMAN; PLASMODIUM FALCIPARUM; PREDATION; STRUCTURE ANALYSIS;

ANIMALS; ANTIMALARIALS; ANTINEOPLASTIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; HT29 CELLS; HUMANS; LEUKEMIA P388; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLLUSCA; PEPTIDES, CYCLIC; PLASMODIUM FALCIPARUM; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; TUMOR CELLS, CULTURED;

MOLLUSCA; NOTASPIDEA; PLASMODIUM FALCIPARUM; PLEUROBRANCHUS;

EID: 0029950818     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np960153t     Document Type: Article

References (15)

1. Invited paper presented at the Young Investigators Symposium at the 36th Annual Meeting of the American Society of Pharmacognosy, Oxford, MS, July 25, 1995.
2. Faulkner, D. J. in Ecological Roles of Marine Natural Products; Paul, V. J., Ed.; Comstock Publishing, Cornell University Press: Ithaca, NY, 1992; pp 119-163.
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10. De Medeiros, E. F.; Herbert, J. M.; Taylor, R. J. K. J. Chem. Soc., Perkin Trans, 1 1991, 2725-2730.
11. Named to recognize the skill and devotion of the first author who isolated the compound and assigned the NMR data while working as an undergraduate research assistant.
12. The sample was identified as Pleurobranchus forskalii, family Pleurobranchaeidae, by Dr. Marc Slattery, Department of Pharmacognosy, The University of Mississippi; a voucher specimen has deposited at the Department of Pharmacognosy, University, Mississippi (94IND214).
13. Hydrolysis of 0.5 mg of peptide was accomplished with 6 N HCl for 22 h. The free amino acids were then derivatized as the isopropyl esters and pentafluoropropy amide prior to GC analysis.
14. Carroll, A. R.; Bowden, B. F.; Coll, J. C.; Hockless, D. C. R.; Skelton, B. W.; White, A. H. Aust. J. Chem. 1994, 47, 61-69.
15. McDonald, L. A.; Foster, M. P.; Phillips, D. R.; Ireland, C. M.; Lee, A. Y.; Clardy, J. J. Org. Chem. 1992, 57, 4616-4624.