The combined action of two thyroidal proteases releases T4 from the dominant hormone-forming site of thyroglobulin

Endocrinology

Volumn 137, Issue 8, 1996, Pages 3279-3285

  Dunn, Ann D ^a,b   Myers, Helen E ^a   Dunn, John T ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; DIPEPTIDYL PEPTIDASE; LYSOSOMAL DIPEPTIDASE; LYSOSOME ENZYME; PROTEINASE; THYROGLOBULIN; THYROXINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; THYROID GLAND; THYROID HORMONE RELEASE;

EID: 0029950661     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.8.8754751     Document Type: Article

References (26)

1. Dunn JT 1991 Thyroglobulin: chemistry and biosynthesis. In: Braverman LE, Utiger RD (eds) The Thyroid. JB Lippincott Co, Philadelphia, pp 98-110
2. Dunn AD, Crutchfield HE, Dunn JT 1991 Proteolytic processing of thyroglobulin by extracts of thyroid lysosomes. Endocrinology 128:3073-3080
3. Kostrouch Z, Munari-Silem Y, Rajas F, Bernier-Valentin F, Rousset B 1991 Thyroglobulin internalized by thyrocytes passes through early and late endosomes. Endocrinology 129:2202-2211
4. Dunn AD, Crutchfield HE, Dunn JT 1991 Thyroglobulin processing by thyroidal proteases. Major sites of cleavage by cathepsins B, D, and L. J Biol Chem 266:20198-20204
5. 4-containing peptide by thyroid thiol proteases. Endocrinology 116:1433-1439
6. McDonald JK, Callahan PX, Ellis S 1971 Polypeptide degradation by dipeptidyl aminopeptidase I (cathepsin C) and related peptidases. In: Barrett AJ, Dingle JT (eds) Tissue Proteinases. North-Holland Publishing Co, Amsterdam, pp 69-107
7. McDonald JK, Barrett AJ 1986 Mammalian Proteases: A Glossary and Bibliography. Academic Press, New York, vol 2:298-300
8. Loughlin RE, Trikojus VM 1964 A metal-dependent peptidase from thyroid glands. Biochim Biophys Acta 92:529-342
9. Aronson NN Jr, Barrett AJ 1978 The specificity of cathepsin B. Biochem J 171:759-765
10. Takahashi T, Dehdarani AH, Yonezawa S, Tang J 1986 Porcine spleen cathepsin B is an exopepridase. J Biol Chem 261:9375-9381
11. Graur D, Duret L, Gouy M 1996 Phylogenetic position of the order Lagomorpha (rabbits, hares and allies). Nature 379:333-335
12. Dunn JT, Dunn AD, Heppner DG Jr, Kim PS 1981 A discrete thyroxine-rich iodopeptide of 20,000 daltons from rabbit thyroglobulin. J Biol Chem 256:942-947
13. Dunn AD 1984 Stimulation of thyroidal thiol endopeptidases by thyrotropin. Endocrinology 114:375-382
14. McDonald JK, Zeitman BB, Ellis S 1972 Detection of a lysosomal carboxypeptidase and a lysosomal dipeptidase in highly-purified dipeptidyl aminopeptidase I (cathepsin C) and the elimination of their activities from preparations used to sequence peptides. Biochem Biophys Res Commun 46:62-70
15. Dunn AD, Dunn JT 1988 Cysteine proteinases from human thyroids and their actions on thyroglobulin. Endocrinology 123:1089-1097
16. Dunn AD, Dunn JT 1982 Thyroglobulin degradation by thyroidal proteases: action of purified cathepsin D. Endocrinology 111:280-289
17. 4. Nature 227:680-685
18. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ 1951 Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
19. Weber K, Osborn M 1969 The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. J Biol Chem 224:4406-4412
20. Fukasawa K, Fukasawa KM, Hiraoka BY, Harada M 1983 Purification and properties of dipeptidyl peptidase II from rat kidney. Biochim Biophys Acta 745:6-11
21. Eisenhauer DA, McDonald JK 1986 A novel dipeptidyl peptidase II from the porcine ovary. J Biol Chem 261:8859-8865
22. Malthiery Y, Lissitzky S 1987 Primary structure of human thyroglobulin deduced from the sequence of its 8448-base complementary DNA. Eur J Biochem 165:491-498
23. Dunn JT, Anderson PC, Fox JW, Fassler CA, Dunn AD, Hite LA, Moore RC 1987 The sites of thyroid hormone formation in rabbit thyroglobulin. J Biol Chem 262:16948-16952
24. Marriq C, Lejeune P-J, Venot N, Vinet L 1991 Hormone formation in the isolated fragment 1-171 of human thyroglobulin involves the couple tyrosine 5 and tyrosine 130. Mol Cell Endocrinol 81:155-164
25. Ieiri T, Cochaux P, Targovnik HM, Suzuki M, Shimoda S, Perret J, Vassart G 1991 A 3′ splice site mutation in the thyroglobulin gene responsible for congenital goiter with hypothyroidism. J Clin Invest 88:1901-1905
26. Lamas L, Anderson PC, Fox JW, Dunn JT 1989 Consensus sequences for early iodination and hormonogenesis in human thyroglobulin. J Biol Chem 264: 13541-13545