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Normal and leukemic SCID-repopulating cells (SRC) co-exist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis
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Sirard C, Lapidot T, Vormoor J, Cashman J, Doedens M, Murdoch B, Jamal N, Messner H, Addey L, Minden M, Laraya P, Keating A, Eaves A, Lansdorp P, Eaves C, Dick J: Normal and leukemic SCID-repopulating cells (SRC) co-exist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis. Blood 1996, 87:1539-1548. This paper describes a system for engrafting SCID mice with chronic-phase CML cells that will lay the foundation for an assay for CML stem cells. Moreover, this paper demonstrates that normal primitive repopulating cells are mobilized into the peripheral blood of patients with CML in addition to primitive CML cells.
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(1996)
Blood
, vol.87
, pp. 1539-1548
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Sirard, C.1
Lapidot, T.2
Vormoor, J.3
Cashman, J.4
Doedens, M.5
Murdoch, B.6
Jamal, N.7
Messner, H.8
Addey, L.9
Minden, M.10
Laraya, P.11
Keating, A.12
Eaves, A.13
Lansdorp, P.14
Eaves, C.15
Dick, J.16
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