Regional Localization of Two MRX Genes to Xq28 (MRX28) and to Xpll.4-Xp22.12 (MRX33)

American Journal of Medical Genetics - Seminars in Medical Genetics

Volumn 64, Issue 1, 1996, Pages 125-130

  Holinski Feder, E ^a   Golla, A ^a   Rost, I ^a   Seidel, H ^a   Rittinger, O ^b   Meindl, A ^a,c  

^a UNIVERSITY OF MUNICH   (Germany)

^b Salzburger Landeskliniken   (Austria)

^c Department of Pediatric Genetics ^*  (Germany)

Author keywords

Gene localization; Linkage analysis; Mental retardation; MRX; Xpll.4 22.12; Xq28

Indexed keywords

ARTICLE; CHROMOSOME XP; CHROMOSOME XQ; CLINICAL ARTICLE; CYTOGENETICS; DNA DETERMINATION; FRAGILE X SYNDROME; GENE LOCATION; GENETIC LINKAGE; GENETIC MARKER; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MENTAL RETARDATION MALFORMATION SYNDROME; NEWBORN; PRIORITY JOURNAL; SCORING SYSTEM;

CHILD, PRESCHOOL; CHROMOSOME MAPPING; DNA; FEMALE; HETEROZYGOTE DETECTION; HUMANS; INFANT; LINKAGE (GENETICS); LOD SCORE; MALE; MENTAL RETARDATION; PEDIGREE; X CHROMOSOME;

EID: 0029950258     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1096-8628(19960712)64:1<125::aid-ajmg21>3.0.co;2-o     Document Type: Article

References (24)

1. Donnelly AJ, Choo AKH, Kozmann HM, Gedeon Ak, Danks DM, Mulley JC (1994): Regional localisation of a non-specific X-linked mental retardation gene (MRX19) to Xp22. Am J Med Genet 51: 581-585.
2. Ellison KA, Roth EJ, McCabe ER, Chinault AC, Zoghbi HY (1993): Isolation of a yeast artificial chromosome contig spanning the X chromosomal translocation beakpoint in a patient with Rett syndrome. Am J Med Genet 47:1124-1134.
3. Fu Y-H, Kuhl DPA, Pizzuti A, Pieretti M, Sutcliffe JS, Richards S, Verkerk AJMH, Holden JJA, Fenwick RG, Warren ST, Oostra BA, Nelson DL, Caskey CT (1991): Variation of the CGG repeat at the fragile site results in genetic instability: Resolution of the Sherman paradox. Cell 67:1047-1058.
4. Gedeon A, Bronwyn K, Mulley J, Turner G (1991): Localisation of the MRX3 gene for non-specific X-linked mental retardation. J Med Genet 28:327-377.
5. Gedeon A, Kerr B, Mulley J, Turner G (1994): Pericentromeric genes for non-specific X-linked mental retardation (MRX). Am J Med Genet 51:553-564.
6. Gendrot C, Ronce N, Toutain A, Moizard M-P, Müh J-p, Raynaud M, Dourlens J, Briault S, Moraine C (1994): X-linked mental retardation exhibiting linkage to DXS255 and PGKP1: A new MRX family (MRX14) with localization in the pericentromeric region. Clin Genet 45:145-153
7. Gyapay G, Morisette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M, Weissenbach J (1994): The 1993-94 Généthon human genetic linkage map. Nature Genet 7: 264-339.
8. Hamel BCJ, Smeets DFCM, Smits APT, van de Helm B, Kremer H, Knoers N, Ropers HH, Mariman EC (1995): X-linked mental retardation: The Nijmengen experience: Highlights and pitfalls. Paper presented at the 7th International Workshop on the Fragile X and X-Linked Mental Retardation. Tromsø, Norway.
9. Kerr B, Gedeon A, Mulley J, Turner G (1992): Localization of non-specific X-linked mental retardation genes. Am J Med Genet 43: 392-401.
10. Knight SJL, Flannery AV, Hirst MC, Campbell L, Christodoulou Z, Phelps SR, Pointon J, Middleton-Price, HR, Barnicoat A, Pembrey ME, Holland J, Oostra BA, Bobrow M, Davies KE (1993): Trinucleotide repeat amplification and hypermethylation of a CpG island in FRAXE mental retardation. Cell 74:127-134.
11. Kondo I, Tsukamoto K, Niikawa N, Okano K, Kanazawa I, Hupkes PE (1991): A new form of X-linked mental retardation (XLMR) linked to DXS369 (RN1). Cytogenet Cell Genet 58:2071.
12. Kozak L, Chiurazzi P, Genuardi M, Pomponi MG, Zollino M, Neri G (1993): Mapping a gene for non-specific X-linked mental retardation: Evidence for linkage to chromosomal region Xp21.1-Xp22.3. J Med Genet 30:866-869.
13. Lathrop GM, Lalouel HM, Julier C, Ott J (1984): Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 81: 3442-3446.
14. Miller SA, Dykes DD, Polesky HF (1988): A simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acids Res 16:1215.
15. Mulley JC, Kerr B, Stevenson R, Lubs H (1992): Nomenclature guidelines for X-linked mental retardation. Am J Med Genet 43: 388-391.
16. Neri G, Chiurazzi P, Arena F, Lubs HA (1994) XLMR Genes: Update 1994. Am J Med Genet 51:542-549.
17. Nordström A-M, Penttinen M, Koskull H (1992): Linkage to Xq28 in a family with nonspecific X-linked mental retardation. Hum Genet 90:263-266.
18. Oostra BA, Verkerk AJMH (1992) The fragile X syndrome: Isolation of the FMR-1 gene and characterization of the fragile X mutation. Chromosoma 101:381-387.
19. Ott J (1991): "Analysis of Human Genetic Linkage," rev ed. Baltimore, MD: John Hopkins University Press.
20. Passos-Bueno MR, Byth BC, Rosenberg S, Takata RI, Bakker E, Beggs AH, Pavanello RC, Vainzof M, Davies KE, Zatz M (1993): Severe non-specific X-linked mental ratardation caused by a proximally Xp located gene. Am J Med Genet 46:172-175.
21. Raeymaekers P, Lin J, Gu XX, Soekarman D, Cassiman JJ, Fryns JP, Marynen P (1995): Non-specific mental retardation is probably caused by a microdeletion in a Belgian family. Paper presented at the 7th International Workshop on the Fragile X and X-Linked Mental Retardation. Tromsø, Norway.
22. Ronce N, Briault S, Toutain A, Moizard MP, Raynaud M, Guichet A, Gendrot C, Moncla A, Francanet C, Manouvier S, Colleaux L, Fontes M, Moraine CI (1995): Seven unpublished XLMR families: Newly reported or recently refined linkage results and phenotype studies. Paper presented at the 7th International Workshop on the Fragile X and X-Linked Mental Retardation. Tromsø, Norway.
23. Turner G, Webb, Wake S, Roninson H (1996): The prevalence of the Fragile X syndrome. Am J Med Genet 64:196-197.
24. Wehnert M, Reiner O, Caskey CT (1993): Four STR polymorphisms map to a 500 kb region between DXS15 and DXS134. Hum Mol Genet 2:1503.