Corticosteroids - Mechanisms of action

Australian Prescriber

Volumn 19, Issue 2, 1996, Pages 41-44

  Funder, John W ^a,b  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

11 hydroxysteroid dehydrogenase; Aldosterone; Cortisol; Glucocorticoid receptor; Mineralocorticoid receptor

Indexed keywords

ALDOSTERONE; CORTICOSTEROID; CORTICOSTERONE; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE;

ADRENAL MEDULLA DISEASE; CORTICOSTEROID RELEASE; DRUG MECHANISM; GENE EXPRESSION REGULATION; HORMONE RECEPTOR INTERACTION; HUMAN; HYPOALDOSTERONISM; PSEUDOHYPOALDOSTERONISM; SHORT SURVEY;

EID: 0029950111     PISSN: 03128008     EISSN: None     Source Type: Journal    
DOI: 10.18773/austprescr.1996.048     Document Type: Article

References (7)

1. Pearce D, Yamamoto KR. Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element. Science 1993;259:1161-5.
2. Krozowski ZS, Funder JW. Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity. Proc Natl Acad Sci USA 1983;80:6056-60.
3. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS. Cloning and tissue distribution of the human 11β hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol 1994;105:R11-R17.
4. Funder JW. Apparent mineralocorticoid excess, 11β hydroxysteroid dehydrogenase and aldosterone action: closing one loop, opening another. Trends Endocrinol Metab 1995;6:248-51.
5. Cheek DB, Perry JW. A salt-wasting syndrome in infancy. Arch Dis Child 1958;33:252-6.
6. Chang SS, Grunder S, Hanukoglu A, Rosler A, Mathew PM, Hanukoglu I, et al. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nature Genetics 1996;12:248-53.
7. Cole TJ, Blendy JA, Monaghan AP, Krieglstein K, Schmid W, Aguzzi A, et al. Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev 1995;9:1608-21.