A gene for nonspecific X-linked mental retardation (MRX41) is located in the distal segment of Xq28

American Journal of Medical Genetics

Volumn 64, Issue 1, 1996, Pages 131-133

  Hamel, Ben C J ^a   Kremer, Hannie ^a   Wesby van Swaay, Eveline ^b   Van Den Helm, Bellinda ^a   Smits, Arie P T ^a   Oostra, Ben A ^b   Ropers, Hans Hilger ^a   Mariman, Edwin C M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

linkage analysis; MRX41; nonspecific X linked mental retardation; Xq28

Indexed keywords

ARTICLE; CHROMOSOME XQ; CLINICAL ARTICLE; GENE LOCATION; GENE MAPPING; GENE SEGREGATION; GENETIC LINKAGE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MENTAL RETARDATION MALFORMATION SYNDROME; PRIORITY JOURNAL; SCORING SYSTEM;

CHROMOSOME MAPPING; FEMALE; HUMANS; LINKAGE (GENETICS); LOD SCORE; MALE; MENTAL RETARDATION; PEDIGREE; X CHROMOSOME;

EID: 0029949944     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19960712)64:1<131::AID-AJMG22>3.0.CO;2-N     Document Type: Article

References (16)

1. Baraitser M, Reardon W, Vijeratnam S (1995): Nonspecific X-linked mental retardation with macrocephaly and obesity: A further family. Am J Med Genet 57:380-384.
2. Fransen E, Schrander-Stumpel C, Vits L, Coucke P, Van Camp G, Willems PJ (1994): X-linked hydrocephalus and MASA syndrome present in one family are due to a single missense mutation in exon 28 of the L1CAM gene. Hum Mol Genet 3:2255-2256.
3. Gedeon A, Kerr B, Mulley J, Turner G (1991): Localization of the MRX3 gene for nonspecific X-linked mental retardation. J Med Genet 28:372-377.
4. Gendrot C, Ronce N, Toutain A, Moizard M-P, Müh J-P, Raynaud M, Dourlens J, Briault S, Moraine C (1994): X-linked mental retardation exhibiting linkage to DXS255 and PGKP1: A new MRX family (MRX14) with localization in the pericentromeric region. Clin Genet 45:145-153.
5. Gregg RG, Metzenberg AB, Hogan K, Sekhon G, Laxová R (1991): Waisman syndrome, a human X-linked recessive basal ganglia disorder with mental retardation: localization to Xq27.3-qter. Genomics 9:701-706.
6. Herbst DS, Miller JR (1980): Non-specific X-linked mental retardation II: The frequency in British Columbia. Am J Med Genet 7:461-469.
7. Holinski-Feder E, Golla A, Rost I, Seidel H, Rittinger O, Wilke K, Meindl A (1995): Linkage analysis and mutation screening in three large families with non-syndromic X-linked mental retardation. Abstract. 7th International Workshop on the Fragile X and X-linked Mental Retardation. Tromsö, Norway August 2-5.
8. Lathrop GM, Lalouel JM, Julier C, Ott J (1985): Multilocus linkage analysis in humans; detection of linkage and estimation of recombination. Am J Hum Genet 37:482-498.
9. Lazzarini A, Stenroos ES, Lehner T, McKoy V, Gold B, McCormack MK, Reid CS, Ott J, Johnson WG (1995): Short tandem repeat polymorphism linkage studies in a new family with X-linked mental retardation (MRX20). Am J Med Genet 57:552-557.
10. Martinez F, Gal A, Plaau F, Prieto F (1995): Localization of a gene for X-linked nonspecific mental retardation (MRX24) in Xp22.2-p22.3. Am J Med Genet 55:387-390.
11. Miller SA, Dykes DD, Polesky HF (1988): A simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acids Res 19:6968.
12. Neri G, Chiurazzi P, Arena JF, Lubs HA (1994): XLMR Genes: Update 1994. Am J Med Genet 51:542-549.
13. Nordström AM, Penttinen M, von Koskull H (1992): Linkage to Xq28 in a family with nonspecific X-linked mental retardation. Hum Genet 90:263-266.
14. Turner G, Turner B (1974): X-linked mental retardation. J Med Genet 11:109-113.
15. Willard HF, Cremers F, Mandel JL, Monaco AP, Nelson DL, Schlessinger D (1994): Report of the fifth international workshop on human X chromosome mapping 1994. Cytogenet Cell Genet 67:296-328.
16. Xuan IY, Hughes-Benzie R, Besner A, Kang X, Ikeda JE, MacKenzie A (1993): Molecular genetic analysis of Simpson-Golabi-Behmel syndrome: an overgrowth condition associated with Wilm's tumor. Am J Hum Genet 53:A1109.