Induction of homotypic lymphocyte aggregation: Evidence for a novel activation state of the β1 integrin

Journal of Leukocyte Biology

Volumn 59, Issue 6, 1996, Pages 872-882

  Neelamegham, Sriram ^a,b,d   Simon, Scott I ^a,b   McIntyre, Bradley W ^c   Zygourakis, Kyriacos ^a  

^a Rice University   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d Texas Children's Hospital   (United States)

Author keywords

Adhesion; Mechanism; Very late activation integrin

Indexed keywords

INTEGRIN; MONOCLONAL ANTIBODY;

ANTIGEN BINDING; ARTICLE; BINDING KINETICS; CELL ADHESION; CELL AGGREGATION; HUMAN; HUMAN CELL; LYMPHOCYTE; PRIORITY JOURNAL;

EID: 0029949845     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.59.6.872     Document Type: Article

References (41)

1. Albelda, S. M., Buck, C. A. (1990) Integrins and other cell adhesion molecules. FASEB J. 4, 2868-2880.
2. Shimizu, Y., Van Seventer, G. A., Horgan, K. J., Shaw, S. (1990) Roles of adhesion molecules in T-cell recognition: fundamental similarities between four integrins on resting human T cells (LFA-1, VLA-4, VLA-5, VLA-6) in expression, binding, and costimulation. Immunol. Rev. 114, 109-143.
3. Springer, T. A. (1990) Adhesion receptors of the immune system. Nature 346, 425-433.
4. Hynes, R. O. (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25.
5. 1-integrin activity on developing retinal neurons. Nature 350, 68-71.
6. 1 integrin-dependent cell adhesion is regulated by a low affinity pool that is conformationally responsive to ligand, J. Biol. Chem. 270, 28740-28750.
7. 1 integrins. Proc. Natl. Acad. Sci. USA 88, 8392-8396.
8. 1 will prevent but not terminate proliferation of human T cells. Cell Adhesion Commun. 2, 169-184.
9. 1 integrins, cytoskeletal proteins, and tyrosine-phosphorylated substrates during integrin-mediated leukocyte aggregation. J. Immunol. 151, 3817-3828.
10. 1 integrin receptors on T cells. Nature 345, 250-253.
11. Hemler, M. E. (1990) VLA proteins in the integrin family: structures, functions and their role on leukocytes. Annu. Rev. Immunal. 8, 365-400.
12. Wayner, E. A., Garcia-Pardo, A., Humphries, M. J., McDonald, J. A., Carter, W. G. (1989) Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin. J. Cell Biol. 109, 1321-1330.
13. 1 subunit function in fibronectin matrix assembly. J. Cell Biol. 110, 1813-1823.
14. 1 subunit. J. Cell Biol. 117, 659-670.
15. van de Wiel-van Kemenade, E., van Kooyk, Y., de Boer, A. J., Huijbens, R. J. F., Weder, P., van de Kasteele, W., Melief, C. J. M., Figdor, C. G. (1992) Adhesion of T and B lymphocytes to extracellular matrix and endothelial cells can be regulated through the β subunit of VLA. J. Cell Biol. 117, 461-470.
16. Elices, M. J., Osborn, L., Takada, Y., Crouse, C., Luhowskyj, S., Hemler, M. E., Lobb, R. R. (1990) VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 60, 577-584.
17. 1 integrin (CD29) stimulates VLA-dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components. J. Cell Biol. 116, 499-509.
18. Bednarczyk, J. L, McIntyre, B. W. (1990) A monoclonal antibody to VLA-4 α-chain (CDw49d) induces homotypic lymphocyte aggregation. J. Immunol. 144, 777-784.
19. Campanero, M. R., Pulido, R., Ursa, M. A., Rodríguez-Moya, M., de Landázuri, M. I., Sánchez-Madrid, F. (1990) An alternative leukocyte homotypic adhesion mechanism, LFA-1/ICAM-1-independent, triggered through the human VLA-4 integrin. J. Cell Biol. 110, 2157-2165.
20. Picker, L. J., Butcher, E.C. (1992) Physiological and molecular mechanisms of lymphocyte homing. Annu. Rev. Immunol. 10, 561-591.
21. Cybulsky, M. I., Gimbrone, M. A., Jr. (1991) Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251, 788-791.
22. Masumoto, A., Hemler, M. E. (1993) Multiple activation states of VLA-4. J. Biol. Chem. 268, 228-234.
23. 1 integrin. Nature 356, 63-66.
24. Clayberger, C., Krensky, A. M., McIntyre, B. W., Koller, T. D., Parham, P., Brodsky, F., Linn, D. J., Evans, E. L. (1987) Identification and characterization of two novel lymphocyte function-associated antigens, L24 and L25. J. Immunol. 138, 1510-1514.
25. 1 subunit. Eur. J. Immunol. 22, 3111-3119.
26. Weitzman, J. B., Pasqualini, R., Takada, Y., Hemler, M. E. (1993) The function and distinctive regulation of the integrin VLA-3 in cell adhesion, spreading, and homotypic cell aggregation. J. Biol. Chem. 268, 8651-8657.
27. Wuthrich, R. P. (1992) Monoclonal antibodies to the murine VLA-6 α-chain trigger homotypic lymphocyte aggregation. Immunol. 77, 214-218.
28. 1 chain monoclonal antibody. J. Biol. Chem. 268, 9863-9868.
29. 1 CD29 integrins induce homotypic and heterotypic cellular aggregation. Cell. Immunol. 138, 216-228.
30. 1. J. Exp. Med. 182, 345-355.
31. 1. J. Immunol. 154, 2112-2124.
32. 1 integrin-ligand interactions. Eur. J. Immunol. 23, 2642-2648.
33. 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J. Biol. Chem. 270, 25570-25577.
34. Munn, L. L., Glacken, M. W., McIntyre, B. W., Zygourakis, K. (1993) Analysis of lymphocyte aggregation using digital image analysis. J. Immunol. Meth. 166, 11-25.
35. Nellamegham, S. Zygourakis, K. A quantitative assay for intercellular aggregation. Ann. Biomed. Eng. In press.
36. 4 subunit cDNA. J. Cell. Biochem. 51, 465-478.
37. 2-integrin and L-selectin-dependent in blood and isolated cells. J. Immunol. 149, 2765-2771.
38. Simon, S. I., Rochon, Y. P., Lynam, E. B., Smith, C. W., Anderson, D. C., Sklar, L. A. (1993) Beta-2 integrin and L-selectin are obligatory receptors in neutrophil aggregation. Blood 82, 1097-1106.
39. McIntyre, B.W., Evans, E. L., Bednarczyk, J. L. (1989) Lymphocyte surface antigen L25 is a member of the integrin receptor super-family. J. Biol. Chem. 264, 13745-13750.
40. Bochner, B. S., Luscinskas, F. W., Gimbrone, M. A., Newman, W., Sterbinsky, S. A., Derse-Anthony, C. P., Klunk, D., Schleimer, R. P. (1991) Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. Exp. Med. 173, 1553-1556.
41. 1 subunit using activating and inhibiting antibodies. J. Biol. Chem. 268, 17597-17601.