Toxicity profile of the investigational new biotherapeutic agent, B43 (anti-CD 19)-pokeweed antiviral protein immunotoxin

Leukemia and Lymphoma

Volumn 22, Issue 1-2, 1996, Pages 61-70

  Gunther, Roland ^b   Chelstrom, Lisa M ^b   Wendorf, Heather R ^b   Schneider, Elizabeth A ^b   Covalciuc, Kristi ^b   Johnson, Bradley ^b   Clementson, Dina ^b   Irvin, James D ^b   Myers, Dorothea E ^b   Uckun, Fatih M ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Univ of Minnesota Biotherapy Prog ^*

Author keywords

Biotherapy; Immunotoxin; Leukemia

Indexed keywords

ANTILEUKEMIC AGENT; CD19 ANTIGEN; DOPAMINE; IMMUNOTOXIN; METHYLPREDNISOLONE; MONOCLONAL ANTIBODY; PENTOXIFYLLINE; POKEWEED ANTIVIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; FEMALE; GAIT DISORDER; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LETHARGY; MOUSE; MUSCLE INJURY; MUSCLE NECROSIS; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; TOXICITY TESTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD19; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARDIOMYOPATHIES; DOPAMINE; FEMALE; HEPATITIS, TOXIC; IMMUNOTOXINS; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; KIDNEY TUBULAR NECROSIS, ACUTE; METHYLPREDNISOLONE; MICE; MICE, INBRED BALB C; MUSCULAR DISEASES; N-GLYCOSYL HYDROLASES; PENTOXIFYLLINE; PLANT PROTEINS; SINGLE-BLIND METHOD;

EID: 0029949776     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199609051729     Document Type: Article

References (12)

1. Waddick, K. G., Gunther, R., Chelstrom L. M., Chandan-Langlie, M., Myers, D. E., Irvin, J. D., Tumer, N., Uckun, F. M. (1995) In vitro and in vivo anti-leukemic activity of B43 (anti-CD 19)-pokeweed antiviral protein immunotoxin against radiation resistant human pre-B acute lymphoblastic leukemia cells. Blood, 86, 4228-4233.
2. Uckun, F. M., Manivel, C., Arthur, D., Chelstrom, L. M., Finnegan, D., Tuel-Ahlgren, L., Irvin, J. D., Myers, D. E., Gunther, R. (1992) In vivo efficacy of B43 (anti-CD 19)-pokeweed antiviral protein immunotoxin against human pre-B cell acute lymphoblastic leukemia in mice with severe combined immunodeficiency. Blood, 79, 2201-2214.
3. Uckun, F. M., Chelstrom, L. M., Finnegan, D., Tuel-Ahlgren, L., Manivel, C., Irvin, J. D., Myers, D. E., Gunther, R. (1992) Effective immunochemotherapy of CALLA + Cμ + human pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19) pokeweed antiviral protein immunotoxin plus cyclophosphamide. Blood, 79, 3116-3129.
4. Gunther, R., Chelstrom, L. M., Finnegan, D., Tuel-Ahlgren, L. Irvin, J. D., Myers, D. E., Uckun, F. M. (1993) In vivo antileukemic efficacy of anti-CD7-pokeweed antiviral protein immunotoxin against human T-lineage acute lymphoblastic leukemia/lymphoma in mice with severe combined immunodeficiency. Leukemia, 7, 298-309.
5. Jansen, B., Kersey, J. H., Jaszcz, W. B., Gunther, R., Nguyen, D. P., Chelstrom, L. M., Tuel-Ahlgren, L., Uckun, F. M. (1993) Effective immunochemotherapy of human t(4;11) leukemia in mice with severe combined immunodeficiency (SCID) using B43 (antiCD19)-pokeweed antiviral protein immunotoxin plus cyclophosphamide. Leukemia, 7, 290-297.
6. Myers, D. E., Uckun, F. M. (1995) An anti-CD72 immunotoxin against therapy-refractory B-lineage acute lymphoblastic leukemia. Leuk. Lymph., 18, 119-122.
7. Myers, D. E., Yanishevski, Y., Masson, E., Irvin, J. D., Evans, W. E. Uckun, F. M. (1995) Favorable pharmacodynamic features and superior anti-leukemic activity of B43 (anti-CD 19) immunotoxins containing two pokeweed antiviral protein molecules covalently linked to each monoclonal antibody molecule. Leuk. Lymph., 18, 93-102.
8. Gunther, R., Chelstrom, L. M., Tuel-Ahlgren, L., Simon, J., Myers, D. E., Uckun, F. M. (1995) Biotherapy for xenografted human central nervous system leukemia in mice with severe combined immunodeficiency using B43 (anti-CD 19)-pokeweed antiviral protein immunotoxin. Blood, 85, 2537-2545.
9. Uckun, F. M., Myers, D. M., Irvin, J. D., Kuebelbeck, V. M., Finnegan, D., Chelstrom, L. M., Houston, L. L. (1993) Effects of the intermolecular toxin-monoclonal antibody linkage on the in vivo stability, immunogenicity, and anti-leukemic activity of B43 (antiCD19) pokeweed antiviral protein immunotoxin. Leuk. Lymph., 9, 459-476.
10. Myers, D. E., Irvin, J. D., Smith, R. S., Kuebelbeck, V. M., Uckun, F. M. (1991) Production of a pokeweed antiviral protein (PAP)-containing immunotoxin, B43-PAP, directed against the CD 19 human B-lineage lymphoid differentiation antigen in highly purified form for human clinical trials. J. Immunol. M., 1 36, 221-238.
11. Uckun, F. M., Reaman, G. H. (1995) Immunotoxins for treatment of leukemia and lymphoma. Leuk. Lymph., 18, 195-201.
12. Uckun, F. M. (1993) Immunotoxins for the treatment of leukemia (Review). Brit. J. Haematol., 85, 435-438.