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Volumn 54, Issue 2 I, 1996, Pages 41-49

The new obesity genes

Author keywords

[No Author keywords available]

Indexed keywords

GENETICS; HUMAN; MOUSE; NONHUMAN; NUTRITION; OBESITY; REVIEW;

EID: 0029949757     PISSN: 00296643     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1753-4887.1996.tb03855.x     Document Type: Review
Times cited : (26)

References (49)
  • 1
    • 0004006894 scopus 로고
    • US Department of Health and Human Services Public Health Service: Washington, DC
    • The Surgeon General's report on nutrition and health. US Department of Health and Human Services Public Health Service: Washington, DC, 1988
    • (1988) The Surgeon General's Report on Nutrition and Health
  • 2
    • 0029366262 scopus 로고
    • Obesity and malnutrition in a shantytown population in the city of Sao Paulo, Brazil
    • Sawaya AL, Dallai G, Solymos G, et al. Obesity and malnutrition in a shantytown population in the city of Sao Paulo, Brazil. Obesity Res 1995;3:107S-15S
    • (1995) Obesity Res , vol.3
    • Sawaya, A.L.1    Dallai, G.2    Solymos, G.3
  • 5
  • 6
    • 0026778869 scopus 로고
    • Evidence for independent genetic influences on obesity in middle age
    • Fabsitz RR, Carmelli D, Hewitt JK. Evidence for independent genetic influences on obesity in middle age. Int J Obesity 1992; 16:657-66
    • (1992) Int J Obesity , vol.16 , pp. 657-666
    • Fabsitz, R.R.1    Carmelli, D.2    Hewitt, J.K.3
  • 7
    • 0027992915 scopus 로고
    • Genetic influences on adult weight gain and maximum body mass index in twins
    • Fabsitz RR, Sholinsky P, Carmelii D. Genetic influences on adult weight gain and maximum body mass index in twins. Am J Epidemiol 1994;140:711-20
    • (1994) Am J Epidemiol , vol.140 , pp. 711-720
    • Fabsitz, R.R.1    Sholinsky, P.2    Carmelii, D.3
  • 9
    • 0027049534 scopus 로고
    • Molecular characterization of the mouse agouti locus
    • Bultman SJ, Michaud EJ, Woychik RP. Molecular characterization of the mouse agouti locus. Cell 1992;71:1195-204
    • (1992) Cell , vol.71 , pp. 1195-1204
    • Bultman, S.J.1    Michaud, E.J.2    Woychik, R.P.3
  • 11
    • 0028112970 scopus 로고
    • Agouti protein is an antagonist of the melanocyte-stimulating hormone receptor
    • Lu D, Willard D, Patel IR, et al. Agouti protein is an antagonist of the melanocyte-stimulating hormone receptor. Nature 1994;371:799-802
    • (1994) Nature , vol.371 , pp. 799-802
    • Lu, D.1    Willard, D.2    Patel, I.R.3
  • 12
    • 0018756428 scopus 로고
    • Hypothalamic and genetic obesity in experimental animals: An autonomic and endocrine hypothesis
    • Bray GA, York DA. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol Rev 1979;59:719-809
    • (1979) Physiol Rev , vol.59 , pp. 719-809
    • Bray, G.A.1    York, D.A.2
  • 13
    • 0027985178 scopus 로고
    • Molecular structure and chromosomal mapping of the human homolog of the agouti gene
    • Kwon HY, Bultman SJ, Loffler C, et al. Molecular structure and chromosomal mapping of the human homolog of the agouti gene. Proc Natl Acad Sci USA 1994;91:9760-4
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9760-9764
    • Kwon, H.Y.1    Bultman, S.J.2    Loffler, C.3
  • 14
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese with diabetes and normal mice
    • Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Dibetologia 1973;9:294-8
    • (1973) Dibetologia , vol.9 , pp. 294-298
    • Coleman, D.L.1
  • 15
    • 0028297731 scopus 로고
    • Appetite and the regulation of body composition
    • Weigle DS. Appetite and the regulation of body composition. FASEB J 1994;8:302-10
    • (1994) FASEB J , vol.8 , pp. 302-310
    • Weigle, D.S.1
  • 17
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995;269:540-3
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.A.1    Cullen, M.J.2    Baker, M.B.3
  • 18
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas JL, Gajiwala KD, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543-6
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1    Gajiwala, K.D.2    Maffei, M.3
  • 19
    • 0029048408 scopus 로고
    • Recombinant mouse ob protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfieid LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546-9
    • (1995) Science , vol.269 , pp. 546-549
    • Campfieid, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 20
    • 0029020677 scopus 로고
    • Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity
    • Considine RV, Considine EL, Williams CJ, et al. Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest 1995;95:2986-8
    • (1995) J Clin Invest , vol.95 , pp. 2986-2988
    • Considine, R.V.1    Considine, E.L.2    Williams, C.J.3
  • 21
    • 0029050937 scopus 로고
    • Over-expression of the obese (ob) gene in adipose tissue of human obese subjects
    • Lonnqvist F, Arner P, Nordfors L, Schalling M. Over-expression of the obese (ob) gene in adipose tissue of human obese subjects. Nature Med 1995;1:950-3
    • (1995) Nature Med , vol.1 , pp. 950-953
    • Lonnqvist, F.1    Arner, P.2    Nordfors, L.3    Schalling, M.4
  • 22
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • Tartaglia LA, Demski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83:1263-71
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1    Demski, M.2    Weng, X.3
  • 23
    • 0028830080 scopus 로고
    • The adipocyte: Storage depot or node on the energy information superhighway?
    • Flier JS. The adipocyte: storage depot or node on the energy information superhighway? Cell 1995;80: 15-8
    • (1995) Cell , vol.80 , pp. 15-18
    • Flier, J.S.1
  • 24
    • 0017828639 scopus 로고
    • Fasting, feeding and regulation of the sympathetic nervous system
    • Landsberg L, Young JB, Fasting, feeding and regulation of the sympathetic nervous system. N Engl J Med 1978;298:1295-301
    • (1978) N Engl J Med , vol.298 , pp. 1295-1301
    • Landsberg, L.1    Young, J.B.2
  • 25
    • 0029040210 scopus 로고
    • Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase e mutation which reduces enzyme activity
    • Naggert JK, Fricker LD, Varlamov O, et al. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nature Genet 1995;10:135-42
    • (1995) Nature Genet , vol.10 , pp. 135-142
    • Naggert, J.K.1    Fricker, L.D.2    Varlamov, O.3
  • 26
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    • Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994;79:1147-56
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 27
    • 0027359896 scopus 로고
    • Strategies for the molecular genetic analysis of obesity in humans
    • Leibel RL, Bahary N, Friedman JM. Strategies for the molecular genetic analysis of obesity in humans. Crit Rev Food Sci Nutr 1993;33:351-8
    • (1993) Crit Rev Food Sci Nutr , vol.33 , pp. 351-358
    • Leibel, R.L.1    Bahary, N.2    Friedman, J.M.3
  • 28
    • 0024205653 scopus 로고
    • Variation of apolipoprotein-B gene is associated with obesity, high blood cholesterol levels, and increased risk of coronary heart disease
    • Rajput-Williams J, Knott TH, Wallis SC, et al. Variation of apolipoprotein-B gene is associated with obesity, high blood cholesterol levels, and increased risk of coronary heart disease. Lancet 1988;2:1442-6
    • (1988) Lancet , vol.2 , pp. 1442-1446
    • Rajput-Williams, J.1    Knott, T.H.2    Wallis, S.C.3
  • 29
    • 0027448688 scopus 로고
    • DNA polymorphisms of the apolipoprotein B gene are associated with obesity and serum lipids in healthy indians in Singapore
    • Saha N, Tay JSH, Heng CK, Humphries SE. DNA polymorphisms of the apolipoprotein B gene are associated with obesity and serum lipids in healthy indians in Singapore. Clin Genet 1993;44:113-20
    • (1993) Clin Genet , vol.44 , pp. 113-120
    • Saha, N.1    Tay, J.S.H.2    Heng, C.K.3    Humphries, S.E.4
  • 30
    • 0028017661 scopus 로고
    • Apolipoprotein-D polymorphism: A genetic marker for obesity and hyperinsulinemia
    • Vijayaraghavan S, Hitman GA, Kopelman PG. Apolipoprotein-D polymorphism: a genetic marker for obesity and hyperinsulinemia. J Clin Endocrinol Metab 1994;79:568-70
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 568-570
    • Vijayaraghavan, S.1    Hitman, G.A.2    Kopelman, P.G.3
  • 31
    • 0028203814 scopus 로고
    • DNA variation in the genes of the Na,K-adenosine triphosphatase and its relation with resting metabolic rate, respiratory quotient, and body fat
    • Deriaz O, Dionne F, Perusse L, et al. DNA variation in the genes of the Na,K-adenosine triphosphatase and its relation with resting metabolic rate, respiratory quotient, and body fat. J Clin Invest 1994;93:838-43
    • (1994) J Clin Invest , vol.93 , pp. 838-843
    • Deriaz, O.1    Dionne, F.2    Perusse, L.3
  • 32
    • 0028136536 scopus 로고
    • DNA polymorphism in the uncoupling protein (UCP) gene and human body fat
    • Oppert JM, Vohl MC, Chagnon M, et al. DNA polymorphism in the uncoupling protein (UCP) gene and human body fat. Int J Obes 1994;18:526-31
    • (1994) Int J Obes , vol.18 , pp. 526-531
    • Oppert, J.M.1    Vohl, M.C.2    Chagnon, M.3
  • 33
    • 0028179074 scopus 로고
    • ApoB-100 gene EcoRI polymorphism. Relations to plasma lipoprotein changes associated with abdominal visceral obesity
    • Pouliot MC, Despres JP, Dionne FT, et al. ApoB-100 gene EcoRI polymorphism. Relations to plasma lipoprotein changes associated with abdominal visceral obesity. Arterioscier Thromb 1994;14:527-33
    • (1994) Arterioscier Thromb , vol.14 , pp. 527-533
    • Pouliot, M.C.1    Despres, J.P.2    Dionne, F.T.3
  • 34
    • 0028978910 scopus 로고
    • 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity
    • 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med 1995;333:352-4
    • (1995) N Engl J Med , vol.333 , pp. 352-354
    • Clement, K.1    Vaisse, C.2    Manning, B.S.3
  • 35
    • 0029145667 scopus 로고
    • Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians
    • Norman RA, Bogardus C, Ravussin E. Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians. J Clin Invest 1995;96:158-62
    • (1995) J Clin Invest , vol.96 , pp. 158-162
    • Norman, R.A.1    Bogardus, C.2    Ravussin, E.3
  • 36
    • 0028926172 scopus 로고
    • Lipoprotein lipase gene polymorphisms: Associations with hypertriglyceridemia and body mass index in obese people
    • Jemaa R, Tuzet S, Portos C, Betoulle S, Apfelbaum M, Fumeron F. Lipoprotein lipase gene polymorphisms: associations with hypertriglyceridemia and body mass index in obese people, Int J Obes 1995: 270-4
    • (1995) Int J Obes , pp. 270-274
    • Jemaa, R.1    Tuzet, S.2    Portos, C.3    Betoulle, S.4    Apfelbaum, M.5    Fumeron, F.6
  • 37
    • 0027497254 scopus 로고
    • Neuropeptide-Y Y1 receptor gene polymorphism: Cross-sectional analyses in essential hypertension and obesity
    • Herzog H, Selbie LA, Zee RYL, Morris BJ, Shine J. Neuropeptide-Y Y1 receptor gene polymorphism: cross-sectional analyses in essential hypertension and obesity. Biochem Biophys Res Commun 1993;196:902-6
    • (1993) Biochem Biophys Res Commun , vol.196 , pp. 902-906
    • Herzog, H.1    Selbie, L.A.2    Zee, R.Y.L.3    Morris, B.J.4    Shine, J.5
  • 38
    • 0026562272 scopus 로고
    • Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans
    • Garruti G, Ricquier D. Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans, Int J Obes 1992;16:383-90
    • (1992) Int J Obes , vol.16 , pp. 383-390
    • Garruti, G.1    Ricquier, D.2
  • 40
    • 0022485610 scopus 로고
    • Cathetin and tumor necrosis factor as two sides of the same biological coin
    • Beutler B, Cerami A. Cathetin and tumor necrosis factor as two sides of the same biological coin. Nature 1986;320:584-8
    • (1986) Nature , vol.320 , pp. 584-588
    • Beutler, B.1    Cerami, A.2
  • 41
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity linked insulin resistance. Science 1993;259:87-91
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 42
    • 0029036594 scopus 로고
    • The lipoprotein lipase HindIII polymorphism modulates plasma triglyceride levels in visceral obesity
    • Vohl MC, Lamarche B, Moorjani S, et al. The lipoprotein lipase HindIII polymorphism modulates plasma triglyceride levels in visceral obesity. Arterioscler Thromb Vasc Biol 1995;15:714-20
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 714-720
    • Vohl, M.C.1    Lamarche, B.2    Moorjani, S.3
  • 43
    • 0027184935 scopus 로고
    • Relationship between skeletal muscle lipoprotein lipase activity and 24-hour macronutrient oxidation
    • Ferraro RT, Eckel RH, Larson DE, et al. Relationship between skeletal muscle lipoprotein lipase activity and 24-hour macronutrient oxidation. J Clin Invest 1993;92:441-5
    • (1993) J Clin Invest , vol.92 , pp. 441-445
    • Ferraro, R.T.1    Eckel, R.H.2    Larson, D.E.3
  • 44
    • 0023544623 scopus 로고
    • Weight reduction increases adipose tissue lipoprotein lipase responsiveness in obese women
    • Eckel RH, Yost TJ. Weight reduction increases adipose tissue lipoprotein lipase responsiveness in obese women. J Clin Invest 1987;80:992-7
    • (1987) J Clin Invest , vol.80 , pp. 992-997
    • Eckel, R.H.1    Yost, T.J.2
  • 45
    • 0003149939 scopus 로고
    • Impacts of body weight, body composition, and adipose tissue distribution on morbidity and mortality
    • Stunkard AJ, Wadden TA, eds. New York: Raven Press
    • Sjostrom L. Impacts of body weight, body composition, and adipose tissue distribution on morbidity and mortality. In: Stunkard AJ, Wadden TA, eds. Obesity: theory and therapy. New York: Raven Press, 1993: 13-41
    • (1993) Obesity: Theory and Therapy , pp. 13-41
    • Sjostrom, L.1
  • 46
    • 0026568387 scopus 로고
    • Central obesity and hyperinsulinaemia in women are associated with polymorphism in the 5′ flanking region of the human insulin gene
    • Weaver JU, Kopelman PG, Hitman GA. Central obesity and hyperinsulinaemia in women are associated with polymorphism in the 5′ flanking region of the human insulin gene. Eur J Clin Invest 1992;22:265-70
    • (1992) Eur J Clin Invest , vol.22 , pp. 265-270
    • Weaver, J.U.1    Kopelman, P.G.2    Hitman, G.A.3
  • 48
    • 0029298442 scopus 로고
    • 2-adrenoceptor genes and regional fat distribution in humans: Association and linkage studies
    • 2-adrenoceptor genes and regional fat distribution in humans: association and linkage studies. Obes Res 1995;3:249-55
    • (1995) Obes Res , vol.3 , pp. 249-255
    • Oppert, J.M.1    Tourville, J.2    Chagnon, M.3


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