Spinal anaesthesia induced by intrathecal magnesium sulphate: An experimental study in a rat model

Anaesthesia

Volumn 51, Issue 7, 1996, Pages 627-633

  Bahar, M ^a,b   Chanimov, M ^a,b   Grinspun, E ^a,b   Koifman, I ^a,b   Cohen, M L ^a,b  

^a ASSAF HAROFEH MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Anaesthetic techniques regional; intrathecal; Pharmacology; magnesium sulphate, lignocaine

Indexed keywords

LIDOCAINE; LOCAL ANESTHETIC AGENT; MAGNESIUM SULFATE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HEMODYNAMICS; INTRATHECAL DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; RESPIRATORY FUNCTION; SEDATION; SPINAL ANESTHESIA;

ANESTHESIA, SPINAL; ANESTHETICS; ANIMALS; CARBON DIOXIDE; HEMODYNAMIC PROCESSES; KINETICS; MAGNESIUM SULFATE; MALE; OXYGEN; PARTIAL PRESSURE; RATS; RATS, WISTAR; RESPIRATION;

EID: 0029949733     PISSN: 00032409     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2044.1996.tb07843.x     Document Type: Article

References (24)

1. GARFINKEL L, GARFINKEL D. Magnesium regulation of the glycotic pathway and the enzymes involved. Magnesium 1985; 4: 60-72.
2. SHILS ME. Experimental human magnesium depletion. Medicine (Baltimore) 1969; 48: 61-85.
3. CHUTKOW JG. The neurophysiologic function of magnesium: an update. Magnesium-Bulletin 1981; 1: 115-20.
4. GARTHWAITE G, HAJOS G, GARTHWAITE J. Ionic requirements for neurotoxic effects of excitatory amino acid analogs in rat cerebellar slices. Neuroscience 1986; 18: 437-47.
5. MORRIS ME. Brain and magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms. Magnesium Research 1992; 5: 303-13.
6. BEHAR M, ROSEN M, VICKERS MD. Chronic cannulation of the intradural or extradural space in the rat. British Journal of Anaesthesia 1984; 56: 405-10.
7. DROR A, HENRIKSEN E. Accidental epidural magnesium sulphate injection. Anesthesia and Analgesia 1987; 66: 1020-1.
8. YAKSH TL, RUDY TA. Studies on the direct spinal action of narcotics in the production of analgesia in the rat. Journal of Pharmacology and Experimental Therapeutics 1977; 202: 411-28.
9. ISERI LT, FRENCH JH. Magnesium: nature's physiologic calcium blocker. American Heart Journal 1984; 108: 188-93.
10. CERF JA. L'action physiologique et pharmacologique des ions alcalino-terreux sur les fibres nerveuses. In: BACQ ZM, ed. Handbuch der experimentellen pharmakologie (Ions alcalinoterreux; tome 1). Berlin: Springer, 1963: 164-274.
11. PECK CH, MELTZER SJ. Anesthesia in human beings by intravenous injection of magnesium sulphate. Journal of American Medical Association 1916; 67: 1131-3.
12. ALDRETE JA. Magnesium physiology and pharmacology in anesthesia. Anesthesiology Review 1987; 14: 33-9.
13. FELDBERG W. Anesthesia and sleep-like conditions produced by injections into cerebral ventricles of cat. Journal of Physiology (London) 1958; 140: 200-1.
14. NOWAK L, BREGESTOVSKI P, ASCHER P, HERBERT A, PROCHIANTZ Z. Magnesium gates glutamate-activated channels in mouse central neurones. Nature 1984; 307: 462-5.
15. HACKMAN JC, DAVIDOFF RA. Dorsal root potentials in the isolated frog spinal cord: amino acid neurotransmitters and magnesium ions. Neuroscience 1991; 41: 61-9.
16. LEVITT M. Dysesthesias and self-mutilation in humans and subhumans: a review of clinical experimental studies. Brain Research 1985; 10: 247-90.
17. SELTZER Z, BEILIN B, GINZBURG R, PARAN Y, SHIMKO T. The role of injury discharge in the induction of neuropathic pain behavior in rats. Pain 1991; 46: 327-36.
18. SELTZER Z, COHN S, GINZBURG R, BEILIN B. Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury discharge. Pain 1991; 45: 69-75.
19. ZELTSER R, SELTZER Z, EISEN A, FEIGENBAUM JJ, MECHOULAM R. Suppression of neuropathic pain behavior in rats by a non-psychotropic synthetic cannabinoid with NMDA receptor-blocking properties. Pain 1991; 47: 95-103.
20. FERIA M, ABAD F, SANCHEZ A, ABREU P. Magnesium sulphate injected subcutaneously suppresses autotomy in peripherally deafferented rats. Pain 1993; 53: 287-93.
21. AMORY DW, JASAITIS MS, WRIGHT C. Use of magnesium to protect against spinal cord ischemia. Anesthesiology 1990; 73: A732.
22. LIU PL, FELDMAN HS, GIASI R, PATTERSON MK, COVINO BG. Comparative CNS toxidty of lidocaine, etidocaine bupivacaine and tetracaine in awake dogs following rapid i.v. administration. Anesthesia and Analgesia 1983; 62: 375-9.
23. JAMES MFM. Clinical use of magnesium infusions in anesthesia. Anesthesia and Analgesia 1992; 74: 129-36.
24. SADEH M. Action of magnesium sulphate in the treatment of preeclampsia-eclampsia. Stroke 1989; 20: 1273-5.