Multiple solutions, illegal parameter values, local minima of the sum of squares, and anomalous parameter estimates in least-squares fitting of the two-compartment pharmacokinetic model with absorption

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 24, Issue 1, 1996, Pages 79-101

  Purves, R D ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

least squares; parameter estimation; pharmacokinetics; two compartment model

Indexed keywords

ALGORITHM; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DATA ANALYSIS; DRUG ABSORPTION; DRUG SOLUTION; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; TREATMENT OUTCOME;

LEAST-SQUARES ANALYSIS; PHARMACOKINETICS;

EID: 0029949040     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02353511     Document Type: Article

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