Lazaroid therapy (methylaminochroman: U83836E) reduces vein graft intimal hyperplasia

Journal of Surgical Research

Volumn 63, Issue 1, 1996, Pages 128-136

  Davies, Mark G ^a   Dalen, Helge ^b   Barber, Lizzie ^a   Svendsen, Einar ^b   Hagen, Per Otto ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]METHYL] 3,4 DIHYDRO 2,5,7,8 TETRAMETHYL 2H 1 BENZOPYRAN 6 OL; ACETYLCHOLINE; BRADYKININ; CALCIUM IONOPHORE; CAPTOPRIL; LAZAROID; NITROPRUSSIDE SODIUM; NORADRENALIN; SEROTONIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; GRAFT SURVIVAL; HISTOPATHOLOGY; MUSCLE TETANIC CONTRACTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE FIBER; VEIN GRAFT;

EID: 0029948980     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0235     Document Type: Conference Paper

References (25)

1. Davies, M. G., and Hagen, P.-O. Pathophysiology of vein graft failure. Eur. J. Vasc. Endovasc. Surg. 9: 7, 1995.
2. Bandyk, D. F., and Mills, J. L. The failing graft: detection and management. Semin. Vasc. Surg. 6: 75, 1993.
3. Mannick, J. A. Improved limb salvage from modern infrainguinal artery bypass techniques. Surgery 111: 361, 1992.
4. Davies, M. G., and Hagen, P.-O. Structural and functional consequences of bypass grafting with autologous vein. Cryobiology 31: 63, 1994.
5. Hagen, P.-O., Davies, M. G., Schuman, R. W., and Murray, J. J. Reduction of vein graft intimal area by ex-vivo treatment with desferroxamine manganese. J. Vasc. Res. 29: 405, 1992.
6. ElSanadiki, M. N., Cross, K. S., Mikat, E. M., and Hagen, P.-O. Verapamil therapy reduces intimal hyperplasia in balloon injured rabbit aorta (abstract). Circulation 76(Suppl.): 314, 1987.
7. O'Donohoe, M. K., Schwartz, L. B., Radic, Z. S., Mikat, E. M., McCann, R. L., and Hagen, P.-O. Chronic ACE inhibition reduces intimal hyperplasia in experimental vein grafts. Ann. Surg. 214: 727, 1991.
8. Davies, M. G., Klyachkin, M. L., Barber, L., Svendsen, E., and Hagen, P.-O. Ramipril and experimental vein graft intimal hyperplasia. Angiology 46: 91, 1995.
9. Davies, M. G., Barber, L., Dalen, H., Svendsen, E., and Hagen, P.-O. Pharmacologic control of the structural and functional consequences of vein graft intimal hyperplasia by a 21-amino-steroid (U74389G). Eur. J. Vasc. Surg. 8: 156, 1994.
10. Whittemore, A. D., Clowes, A. W., Couch, N. P., and Mannick, J. A. Secondary femoropopliteal reconstruction. Ann. Surg. 193: 35, 1980.
11. Green, R. M., Ouriel, K., Ricotta, J. J., and deWeese, J. A. Revision of failed infrainguinal bypass graft: principles of management. Surgery 100: 646, 1986.
12. Davies, M. G., and Hagen, P.-O. Pathobiology of intimal hyperplasia. Br. J. Surg. 81: 1254, 1994.
13. Chervu, A., and Moore, W. S. An overview of intimal hyperplasia. Surg. Gynecol. Obstet. 171: 433, 1990.
14. Ip, J. H., Fuster, V., Badimon, L., Taubman, M. B., and Chesebro, J. H. Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation. J. Am. Coll. Cardiol. 15: 1667, 1990.
15. Sayers, R. D., Jones, L., Varty, K., et al. The histopathology of infrainguinal vein graft stenoses. Eur. J. Vasc. Surg. 7: 16, 1993.
16. Berkowitz, H. D., Fox, A. D., and Deaton, D. H. Reversed vein graft stenosis: early diagnosis and management. J. Vasc. Surg. 15: 130, 1992.
17. Braughler, J. M., Pregenzer, J. F., Chase, R. L., Duncan, L. A., and McCall, J. M. Novel 21-aminosteroid as potent inhibitor of iron dependent lipid peroxidation. J. Biol. Chem. 262: 10438, 1987.
18. Cross, C. E., Halliwell, B., Borish, E. T., et al. Oxygen radicals and human disease. Ann. Intern. Med. 107: 526, 1987.
19. Halliwell, B. Oxidants and human disease: some new concepts. FASEB J. 1: 358, 1987.
20. Floyd, R. A. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J. 4: 2587, 1987.
21. Thomas, P. D., Mao, G. D., Rabinovitch, A., and Poznansky, M. J. Inhibition of superoxide generating NADPH oxidase of human neutrophils by lazaroids (21-aminosteroids and 2-methylaminochromans). Biochem. Pharmacol. 45: 241, 1993.
22. Singh, J. P., and Boubin, P. D. Inhibition of proliferation of fibroblasts by lazaroids (21-aminosteroids). Life Sci. 49: 2053, 1991.
23. Ankers, D. L., Aurora, H. S., Bedi, B., et al. Effect of 21-amino-steroid antioxidant U74389F on development of intimal hyperplasia following balloon catheter injury in rabbit thoracic aorta (abstract). FASEB J. 7: A339, 1993.
24. Bonin, P. D., Singh, J. P., Gammill, R. B., and Erickson, L. A. Inhibition of fibroblast and smooth muscle cell proliferation and migration in vitro by a novel aminochrome U67154. J. Vasc. Res. 30: 108, 1993.
25. Davies, M. G., Kim, J. H., Makhoul, R. G., Dalen, H., Svendsen, E., and Hagen, P.-O. Reduction of intimal hyperplasia and preservation of nitric oxide (NO)-mediated relaxation by the NO precursor: L-arginine. Surgery 116: 557, 1994.