Intraperitoneal administration of ascorbic acid delays the turnover of3H-labelled cortisol in the plasma of an ODS rat, but not in the wistar rat. Evidence in support of the cardinal role of vitamin c in the progression of glucocorticoid synthesis

In Vivo

Volumn 10, Issue 1, 1996, Pages 97-102

  Kodama, Masahiko ^a,b   Inoue, Fukiko ^a   Kodama, Toshiko ^b   Kodama, Mitsuo ^b  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b Kodama Research Institute of Preventive Medicine   (Japan)

Author keywords

Cortisol turnover; Functional linkage; Glucocorticoid enhancement; Rat experiment; Scurvy prone rat; Vitamin C

Indexed keywords

ASCORBIC ACID; HYDROCORTISONE; TRITIUM;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD; CONTROLLED STUDY; CORTICOSTEROID METABOLISM; HYDROCORTISONE BLOOD LEVEL; ISOTOPE LABELING; LIVER; NONHUMAN; RAT; STEROIDOGENESIS; TESTIS;

EID: 0029948950     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Kodama M, Kodama T, Murakami M and Kodama M: Autoimmune disease and allergy are controlled by vitamin C treatment. In Vivo 8: 251-258, 1994.
2. Kodama M, Kodama T, Murakami M and Kodama M: Vitamin C infusion treatment enhances cortisol production of the adrenal via the pituitary ACTH route. In Vivo 8: 1079-1086, 1994.
3. Mizushima T, Harauchi T, Yoshizaki T and Makino S: A rat mutant unable to synthesize vitamin C. Experimentia 40: 359-361, 1984.
4. Nishikimi M, Koshizaka T, Kondo K, Ozawa T and Yagi K: Expression of the mutant gene for L-gulono-γ-lactone oxidase in scurvy-prone rats. Experientia 45: 126-129, 1989.
5. Kodama M, Kodama T and Kodama M: Interaction between N-methyl-N'-nitro-N-nitrosoguanidine and 2 steroid hormones in the glandular stomach of mouse. I. Acceleration of hydrocortisone turnover by use of a salt-rich diet and the carcinogen. Biomed & Pharmacother 43: 192-205, 1989.
6. Kodama M and Kodama T: Hormonal status of breast cancer. I. Theoretical basis for the analysis of steroid profile. J Natl Cancer Inst 54: 1023-1029, 1975.
7. Kodama M, Kodama T, Totani R and Aso Y: The regularity of intersteroidal relations in urine as related to the law of mass action. In Vivo 5: 127-136, 1991.
8. Clemetson CAV: Adrenal corticoid metabolism. In: Vitamin C vol III, 1989. CRC Press, Inc., Boca Raton, Florida, USA, pp 101-111.
9. Kodama M, Kodama T and Kodama M: Vitamin C, steroid and environmental carcinogenesis (Review). Int J Oncol 6: 797-815, 1995.