메뉴 건너뛰기




Volumn 172, Issue 1, 1996, Pages 143-147

Missense mutations at the FKBP12-rapamycin-binding site of TOR1

Author keywords

Immunophilin; PI kinase; Saccharomyces cerevisiae

Indexed keywords

ANTIFUNGAL AGENT; ARGININE; ASPARTIC ACID; PHOSPHATIDYLINOSITOL KINASE; PROTEIN KINASE C; RAPAMYCIN; SERINE; THREONINE;

EID: 0029948739     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-1119(96)00168-0     Document Type: Article
Times cited : (8)

References (20)
  • 1
  • 4
    • 0028344699 scopus 로고
    • Yeast TOR (DRR) proteins: Amino-acid sequence alignment and identification of structural motifs
    • Cafferkey, R., McLaughlin, M.M., Young, P.R., Johnson, R.K., Bergsma, D.J. and Livi, G.P.: Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs. Gene 141 (1994) 133-136.
    • (1994) Gene , vol.141 , pp. 133-136
    • Cafferkey, R.1    McLaughlin, M.M.2    Young, P.R.3    Johnson, R.K.4    Bergsma, D.J.5    Livi, G.P.6
  • 5
    • 0029055145 scopus 로고
    • Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue
    • Chen, J., Zheng, X.-F., Brown, E.J. and Schreiber S.L.: Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc. Natl. Acad. Sci. USA 92 (1995) 4947-4951.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4947-4951
    • Chen, J.1    Zheng, X.-F.2    Brown, E.J.3    Schreiber, S.L.4
  • 6
    • 0028598672 scopus 로고
    • RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
    • Chiu, M.I., Katz, H. and Berlin, V.: RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc. Natl. Acad. Sci. USA 91 (1994) 12574-12578.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12574-12578
    • Chiu, M.I.1    Katz, H.2    Berlin, V.3
  • 7
    • 0343625415 scopus 로고
    • Missense mutations at the FKBP 12-rapamycin binding site of TOR1
    • Cold Spring Harbor, NY
    • Freeman, K. and Livi, G.P.: Missense mutations at the FKBP 12-rapamycin binding site of TOR1. Presented at the Yeast Cell Biology meeting, Cold Spring Harbor, NY, 1995, p. 121.
    • (1995) Yeast Cell Biology Meeting , pp. 121
    • Freeman, K.1    Livi, G.P.2
  • 8
    • 0026012156 scopus 로고
    • FK506-binding protein proline rotamase is a target for the immuno-suppressive agent FK506 in Saccharomyces cerevisiae
    • Heitman, J., Movva, N.R., Hiestand, P.C. and Hall, M.N.: FK506-binding protein proline rotamase is a target for the immuno-suppressive agent FK506 in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 88 (1991a) 1948-1952.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 1948-1952
    • Heitman, J.1    Movva, N.R.2    Hiestand, P.C.3    Hall, M.N.4
  • 9
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman, J., Movva, N.R. and Hall, M.N.: Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253 (1991b) 905-909.
    • (1991) Science , vol.253 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 10
    • 0028137771 scopus 로고
    • TOR1 and TOR2 are structurally and functionally similar but not identical phosphotidylinositol kinase homologues in yeast
    • Helliwell, S.B., Wagner, P., Kunz, J., Deuter-Reinhard, M., Henriquez, R., and Hall, M.N.: TOR1 and TOR2 are structurally and functionally similar but not identical phosphotidylinositol kinase homologues in yeast. Mol. Biol. Cell. 5 (1994) 105-118.
    • (1994) Mol. Biol. Cell. , vol.5 , pp. 105-118
    • Helliwell, S.B.1    Wagner, P.2    Kunz, J.3    Deuter-Reinhard, M.4    Henriquez, R.5    Hall, M.N.6
  • 11
    • 0026092585 scopus 로고
    • Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to FK506-binding protein
    • Koltin, Y., Faucette, L., Bergsma, D.J., Levy, M.A., Cafferkey, R., Koser, P.L., Johnson, R.K. and Livi, G.P.: Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to FK506-binding protein. Mol. Cell. Biol. 11 (1991) 1718-1723.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 1718-1723
    • Koltin, Y.1    Faucette, L.2    Bergsma, D.J.3    Levy, M.A.4    Cafferkey, R.5    Koser, P.L.6    Johnson, R.K.7    Livi, G.P.8
  • 13
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP12-FK506 complexes
    • Liu, J., Farmer, J.D., Lane, W.S., Friedman, J., Wiessman, I. and Schreiber, S.L.: Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP12-FK506 complexes. Cell 66 (1991) 807-815.
    • (1991) Cell , vol.66 , pp. 807-815
    • Liu, J.1    Farmer, J.D.2    Lane, W.S.3    Friedman, J.4    Wiessman, I.5    Schreiber, S.L.6
  • 14
    • 0028004378 scopus 로고
    • Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1
    • Moretti, P., Freeman, K. and Shore, D.: Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1. Genes Dev. 8 (1994) 2257-2269.
    • (1994) Genes Dev. , vol.8 , pp. 2257-2269
    • Moretti, P.1    Freeman, K.2    Shore, D.3
  • 15
    • 0028239893 scopus 로고
    • RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
    • Sabatini, D.M., Erdjument-Bromage, H., Lui, M., Tempst, P. and Snyder, S.H.: RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78 (1994) 35-43.
    • (1994) Cell , vol.78 , pp. 35-43
    • Sabatini, D.M.1    Erdjument-Bromage, H.2    Lui, M.3    Tempst, P.4    Snyder, S.H.5
  • 16
    • 0027905021 scopus 로고
    • Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
    • Schu, P.V., Takegawa, K., Fry, M.J., Stack, J.H., Waterfield, M.D. and Emr, S.D.: Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 260 (1993) 88-91.
    • (1993) Science , vol.260 , pp. 88-91
    • Schu, P.V.1    Takegawa, K.2    Fry, M.J.3    Stack, J.H.4    Waterfield, M.D.5    Emr, S.D.6
  • 17
    • 0024669291 scopus 로고
    • A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
    • Sikorski, R. and Hieter, P.: A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122 (1989) 19-27.
    • (1989) Genetics , vol.122 , pp. 19-27
    • Sikorski, R.1    Hieter, P.2
  • 19
    • 0024977417 scopus 로고
    • Elevated recombination rates in transcriptionally active DNA
    • Thomas, B.J. and Rothstein, R.: Elevated recombination rates in transcriptionally active DNA. Cell 56 (1989) 619-630.
    • (1989) Cell , vol.56 , pp. 619-630
    • Thomas, B.J.1    Rothstein, R.2
  • 20
    • 0029071264 scopus 로고
    • TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin
    • Zheng, X.-F., Florentino, D., Chen, J., Crabtree, G.R. and Schreiber, S.L.: TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell 82 (1995) 121-130.
    • (1995) Cell , vol.82 , pp. 121-130
    • Zheng, X.-F.1    Florentino, D.2    Chen, J.3    Crabtree, G.R.4    Schreiber, S.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.