T cell autoimmunity to glutamic acid decarboxylase in human insulin-dependent diabetes mellitus

Hormone and Metabolic Research

Volumn 28, Issue 7, 1996, Pages 357-360

  Lohmann, T ^a   Scherbaum, W A ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

autoimmunity; GAD; IDDM; T cells

Indexed keywords

AUTOANTIBODY; GLUTAMATE DECARBOXYLASE;

AUTOIMMUNITY; CONFERENCE PAPER; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TECHNIQUE;

EID: 0029948414     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-979815     Document Type: Conference Paper

References (29)

1. Atkinson, M. a., D. L. Kaufman, L. Campbell, K. A. Gibbs, S. C. Shah, D.-F. Bu, M. G. Erlander, A. J. Tobin, N. K. Maclaren: Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet 339: 458-459 (1992)
2. Atkinson, M. A., M. A. Bowman, K.-J. Kao, L. Campbell, P. J. Dush, S. C. Shah, O. Simell, N. K. Maclaren: Lack of immune responsiveness to bovine serum albumin in insulin-dependent diabetes. N. Engl. J. Med. 329: 1853-1858 (1993)
3. Atkinson, M. a., M. A. Bowman, L. Campbell, B. L. Darrow, D. L. Kaufman, N. K. Madaren: Cellular immunity to a determinant common to glutamate decarboxylase and Coxsackie virus in insulin-dependent diabetes. J. Clin. Invest. 94: 2125-2129 (1994)
4. Baekkeskov, S., H.-J. Aanstoot, S. Chrisgau, A. Reetz, M. Solimena, M. Cascalho, F. Folli, H. Richter-Olesen, P. De Camilli: Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347: 151-156 (1990)
5. Barker, R. N., C. J. Elson: Multiple self epitopes on the Rhesus polypeptides stimulate immunologically ignorant human T cells in vitro. Eur. J. Immunol. 24: 1578-1582 (1994)
6. Bu, D.-F., M. G. Erlander, B. C. Hitz, N. J. K. Tillakaretne, D. L. Kaufman, C. B. Wgner-McPherson, G. A. Evans, A. J. Tobin: Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. Proc. Natl. Acad. Sci. USA 89: 2115-2119 (1992)
7. Cheung, R., UJ. Karjalainen, J. Vandermeulen, D. P. Singal, H.-M. Dosch: T cells from children with IDDM are sensitized to bovine serum albumin. Scand. J. Immunol. 40: 623-628 (1994)
8. Fairchild, P. J., C. J. Thorpe, P. J. Travers, D. C. Wraith: Modulation of the immune responses with T-cell epitopes: the ultimate goal for specific immunotherapy of autoimmune disease. Immunology 81: 487-496 (1994)
9. Harrison, L. C., M. C. Honeyman, H. J. DeAizpura, R. S. Schmidli, P. G. Colman, B. D. Tait, D. S. Cram: Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Lancet 341: 1365-1369 (1993)
10. Honeyman, M. C., D. S. Cram, L. C. Harrison: Glutamic acid decarboxylase 67-reactive T cells: A marker of insulin-dependent diabetes. J. Exp. Med. 177: 535-540 (1993)
11. Jones, D. B., A. F. W. Coulson, G. W. Duff: Sequence homologies between hsp60 and autoantigens. Immunol. Today 14: 115-118 (1993)
12. Katz, J. D., B. Wang, K. Haskins, C. Benoist, D. Mathis: Following a diabetogenic T cell from genesis through pathogenesis. Cell 74: 1089-1100 (1993)
13. Kaufman, D. L., M. G. Erlander, M. Clare-Salzler, M. A. Atkinson, N. K. Maclaren, A. J. Tobin: Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J. Clin. Invest. 89: 283-292 (1992)
14. Kaufman, D. L., M. Clare-Salzler, J. Tian, T. Forsthuber, G. S. P. Ting, P. Robinson, M. A. Atkinson, E. E. Sercarz, A. J. Tobin, P. V. Lehmann: Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366: 69-72 (1993)
15. Keller, R. J., G. S. Eisenbarth, R. A. Jackson: Insulin prophylaxis in individuals at high risk of type I diabetes. Lancet 341: 927-928 (1993)
16. Lehmann, P. V., E. E. Sercarz, T. Forsthuber, C. M. Dayan, G. Gammon: Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol. Today 14: 23-208 (1993)
17. Lohmann, T., R. D. G. Leslie, M. Hawa, M. Geysen, S. Rodda, M. Londei: Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus. Lancet 343: 1607-1608 (1994)
18. Miller, G. G., M. S. Pollack, L. J. Nell, J. W. Thomas: Insulin-specific human T cells. J. Immunol. 139: 3622-3629 (1987)
19. Naquet, P., J. Ellis, D. Tibensky, A. Kenshole, B. Singh, R. Hodges, T. L. Delovitch: T cell autoreactivity to insulin in diabetic and related non-diabetic individuals. J. Immunol. 140: 2569-2578 (1988)
20. Nerup, J., O. O. Andersen, G. Bendixen, J. Egeberg, R. Gunnarsson, H. Kromann, J. E. Poulsen: Cell-mediated immunity in diabetes mellitus. Proc. Roy. Soc. Med. 67: 506-513 (1974)
21. Panina-Bordignon, P., R. Lang, P. M. van Endert, E. Benazzi, A. M. Felix, R. M. Pastore, G. A. Spinas, F. Sinigaglia: Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes. J. Exp. Med. 181: 1923-1927 (1995)
22. Reece, J. C., H. M. Geysen, S. J. Rodda: Mapping the major human T helper epitopes of tetanus toxin. J. Immunol. 151: 6175-6184 (1993)
23. Robinson, B. H., H.-M. Dosch, J. M. Martin, H. K. Akerblom, E. Savilahti, M. Knip, J. Ilonen: A model for the involvement of MHC class II proteins in the development of Type 1 (insulin-dependent) diabetes mellitus in response to bovine serum albumin peptides. Diabetologia 36: 364-368 (1993)
24. Roep, B. O., A. A. Kallan, W. L. W. Hazenbos, G. J. Bruining, E. M. Bailyes, S. D. Arden, J. C. Hutton, R. R. P. DeVries: T-cell reactivity to 38kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes. Lancet 337: 1439-1441 (1991)
25. Tisch, R., X.-D. Yang, S. M. Singer, R. S. Liblau, L. Fugger, H. O. McDevitt: Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366: 72-75 (1993)
26. Trentham, D. E., R. A. Dynesius-Trentham, E. J. Orav, D. Combitchi, C. Lorenzo, K. L. Sewell, D. A. Hafler, H. L. Weiner: Effects of oral administration of Type II collagen on rheumatoid arthritis. Science 261: 1727-1730 (1993)
27. Weiner, H. L., G. A. Mackin, M. Matsui, E. J. Orav, S. J. Khoury, D. M. Dawson, D. A. Hafler: Double-blind trial of oral tolerization with myelin antigens in multiple sclerosis. Science 259: 1321-1324 (1993)
28. Zhang, J., R. Medaer, P. Stinissen, D. Hafler, J. Raus: MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination. Science 261: 1451-1454 (1993)
29. Zhang, J., S. Markovic-Plese, B. Lacet, J. Raus, H., L. Weiner, D. A. Hafler: Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J. Exp. Med. 179: 973-984 (1994)