Vasomotor response to pentoxifylline mediates improved renal blood flow in bacteremia

Journal of Surgical Research

Volumn 63, Issue 1, 1996, Pages 17-22

  Krysztopik, R J ^a   Bentley, F R ^a   Wilson, M A ^a   Spain, D A ^a   Garrison, R N ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; PENTOXIFYLLINE;

ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; BACTEREMIA; CONFERENCE PAPER; CONTROLLED STUDY; ESCHERICHIA COLI; HEART OUTPUT; HYDRONEPHROSIS; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY ARTERY; KIDNEY BLOOD FLOW; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

EID: 0029948223     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0215     Document Type: Conference Paper

References (56)

1. Jochimsen, F., Schafer, J., Maurer, A., and Distler, A. Impairment of renal function in the medical intensive care: predictability of acute renal failure. Crit. Care Med. 18: 480-485, 1990.
2. Turney, J. H., Marshall, D. H., Brownjohn, A. M., Ellis, C. M., and Parsons, F. M. The evolution of acute renal failure, 1956-1988. Q. J. Med. 273: 83-104, 1990.
3. Groenveld, A. B. J., Tran, D. D., Van der Muelen, J., Nauta, J. J. P., and Thijs, L. G. Acute renal failure in the medical intensive care unit: predisposing, complicating factors and outcome. Nephron 59: 602-610, 1991.
4. Van der Merwe, W. M., and Collins, J. F. Acute renal failure in a critical care unit. N. Z. Med. J. 102: 96-98, 1989.
5. Shen, P. F., and Zhang, S. Acute renal failure and multiple organ system failure. Arch. Surg. 122: 1131-1133, 1987.
6. Lucas, C. The renal response to acute injury and sepsis. Surg. Clin. North Am. 56: 953-957, 1976.
7. Reubi, F. C., and Vorburger, C. Renal hemodynamics in acute renal failure after shock in man. Kidney Int. 10: S137-S141, 1976.
8. Lugon, J. R., Boim, M. A., Oswaldo, L. R., Ajzen, H., and Schor, N. Renal function and glomerular hemodynamics in male endotoxemic rats. Kidney Int. 36: 570-575, 1989.
9. Passmore, J. C., Neiburger, R. E., and Eden, S. W. Measurement of intrarenal anatomic distribution of krypton-85 in endotoxic shock dogs. Am. J. Physiol. 232: H54-H62, 1976.
10. Garrison, R. N., Wilson, M. A., Matheson, P. J., and Spain, D. A. Nitric oxide mediates redistribution of intrarenal blood flow during bacteremia. J. Trauma 39(1): 90-97, 1995.
11. Cryer, H. G., Bloom, I. T. M., Unger, L. S., and Garrison, R. N. Factors affecting renal microvascular blood flow in rat hyperdynamic bacteremia. Am. J. Physiol. 264: H1988-H1997, 1993.
12. Morise, Z., Ueda, M., Aiura, K., Endo, M., and Kitajima, M. Pathophysiological role of endothelin-1 in renal function in rats with endotoxin shock. Surgery 115(2): 199-204, 1994.
13. Higenfeldt, G., Kienapfel, G., Kellerman, W., Schott, R., and Schmidt, M. Renin angiotensin system in sepsis. Clin. Exp. Theory Pract. A9(8&9): 1493-1504, 1987.
14. 2 receptors. J. Clin. Invest. 90: 136-141, 1992.
15. 2 and leukotrienes in endotoxin induced acute renal failure. Kidney Int. 30: 474-480, 1986.
16. Beck, R. B., Abel, F. L., and Papadakis, E. Influence of Ibuprofen on renal function in acutely endotoxemic dogs. Circ. Shock 28: 37-47, 1989.
17. Spain, D. A., Wilson, M. A., and Garrison, R. N. Nitric oxide synthase inhibition exacerbates sepsis induced renal hypoperfusion. Surgery 116: 322-331, 1994.
18. Spain, D. A., Wilson, M. A., Bloom, I. T. M., and Garrison, R. N. Renal microvascular responses to sepsis are dependant on nitric oxide. J. Surg. Res. 56(6): 524-529, 1994.
19. Schroer, R. Antithrombotic potential of pentoxifylline, a hemorrheologically active drug. Angiology 36: 387-398, 1985.
20. Vadiei, K., Brunner, L. J., and Luke, D. R. Effects of pentoxifylline in experimental acute renal failure. Kidney Int. 36: 466-470, 1989.
21. Wang, P., Ba, Z. F., Zhou, M., Tait, S., and Chaudry, I. H. Pentoxifylline restores cardiac output and tissue perfusion after trauma-hemorrhage and decreases susceptibility to sepsis. Surgery 114: 352-359, 1993.
22. Lauterbach, R., Pawlik, D., Tomaszczyk, B., and Cholewa, B. Pentoxifylline treatment of sepsis of premature infants: preliminary clinical observations. Eur. J. Pediatr. 153: 672-674, 1994.
23. Berens, K. L., Langston, J. D., Wasan, K. M., and Luke, D. R. Influence of pentoxifylline and related analogues in endotoxemic renal failure. Circ. Shock 34: 344-348, 1991.
24. McDougal, W. S. Renal perfusion/reperfusion injuries. J. Urol. 140: 1325-1330, 1988.
25. Churchill, P. C., Bidani, A. K., and Schwartz, M. M. Renal effects of endotoxin in the male rat. Am. J. Physiol. 22: F244-F250, 1987.
26. Weitzberg, E., Lundberg, J. M., and Rudehill, A. Elevated levels of endothelin in patients with sepsis syndrome. Circ. Shock 33: 222-227, 1991.
27. Kon, V., and Badr, K. F. Biological and pathophysiological significance of endothelin in the kidney. Kidney Int. 40: 1-12, 1991.
28. Sugiura, M., Inagami, T., and Kon, V. Endotoxin stimulates endothelin release in-vivo and in-vitro as determined by radioimmunoassay. Biochem. Biophys. Res. Commun. 161: 1220-1227, 1989.
29. Cryer, H. M., Unger, L. S., Garrison, R. N., and Harris, P. D. Prostaglandins maintain renal blood flow during hyperdynamic bacteremia. Circ. Shock 26: 71-88, 1988.
30. Harada, H., Ishizaka, A., Yonemaru, M., Mallick, A. A., Hatherill, J. R., Zheng, H., Lilly, C. M., and O'Hanley, P. T. The effects of aminophylline and pentoxifylline on multiple organ damage after Escherichia coli sepsis. Am. Rev. Respir. Dis. 140: 974-980, 1989.
31. Ishizaka, A., Wu, Z., Stephens, K. E., Harada, H., Hogue, R. S., O'Hanley, P. T., and Raffin, T. A. Attenuation of acute lung injury in septic guinea pigs by pentoxifylline. Am. Rev. Respir. Dis. 138: 376-382, 1988.
32. Strieter, R. M., Remick, D. G., Spengler, W. R. N., Lynch, J. P., Larrick, J., and Kunkel, S. L. Cellular and molecular regulation of tumour necrosis factor-alpha production by pentoxifylline. Biochem. Biophys. Res. Commun. 155: 1230-1236, 1988.
33. Sullivan, G. W., Carper, H. T., Novick, W. J., and Mandell, G. L. Inhibition of the inflammatory action of interleukin-1 and tumour necrosis factor (alpha) pn neutrophil function by pentoxifylline. Infect. Immun. 56: 1722-1729, 1988.
34. Bloom, I. T. M., Bentley, F. R., and Garrison, R. N. Escherichia coli bacteraemia exacerbates cyclosporine induced renal vasoconstriction. J. Surg. Res. 54: 510-516, 1993.
35. Buhrle, C. P., Hackenthal, E., Helmchen, U., Lackner, K., Nobiling, R., Steinhausen, M., and Taugner, R. The hydronephrotic kidney in the mouse as a tool for intravital microscopy and in vitro electrophysiological studies of renin containing cells. Lab. Invest. 54(4): 462-472, 1986.
36. Kelleher, J. P., Shah, V., Godley, M. L., Wakefield, A. J., Gordon, I., Ransley, P. G., Snell, M. E., Risdon, and R. A. Urinary endothelin (ET1) in complete ureteric obstruction in the miniature pig. Urol. Res. 20(1): 63-65, 1992.
37. Hanss, B. G., Lewy, J. E., and Vari, R. C. Alterations in glomerular dynamics in congenital, unilateral hydronephrosis. Kidney Int. 46(1): 48-57, 1994.
38. Gulbins, E., Hoffend, J., Zou, A. P., Dietrich, M. S., Schlottmann, K., Cavarape, A., and Steinhausen, M. Endothelin and endothelium derived relaxing factor control of basal renovascular tone in hydronephrotic rat kidneys. J. Physiol. 469: 571-582, 1993.
39. Schlottman, K., Gulbins, E., Rauterberg, E. W., and Steinhausen, M. Effects of systemic complement activation on renal circulation of rats. Eur. J. Clin. Invest. 24(5): 320-330, 1994.
40. Bloom, I. T. M., Bentley, F. R., Wilson, M. A., and Garrison, R. N. In vivo effects of endothelin on the renal microcirculation. J. Surg. Res. 54(4): 274-280, 1993.
41. Steinhausen, M., Weis, S., Fleming, J. T., Dussel, R., and Parekh, N. Responses of in-vivo renal vessels to dopamine. Kidney Int. 30: 361-370, 1986.
42. Steinhausen, M., Sterzel, R. B., Fleming, J. T., Kuhn, R., and Weis, S. Acute and chronic effects of angiotensin II on the vessels of the split hydronephrotic kidney. Kidney Int. 31(Suppl.): S64-S69, 1987.
43. Waxman, K., Holness, R., Tominaga, G., Oslund, S., Pinderski, L., and Soliman, M. H. Pentoxifylline improves tissue oxygenation after hemorrhagic shock. Surgery 102: 358-361, 1987.
44. Chalkiadakis, G. E., Kostakis, A., Karayannacos, P. E., Chalkiadakis, M. E., Sgouromali, S., Giamarellou, H., and Skalkaes, G. D. Pentoxifylline in the treatment of experimental peritonitis on rats. Arch. Surg. 120: 1141-1144, 1985.
45. Schade, U. F. Pentoxifylline increases survival in murine endotoxin shock and decreases formation of tumour necrosis factor. Circ. Shock 31: 171-181, 1990.
46. Myers, S. I., Horton, J. W., Hernandez, R., Walker, P. B., and Vaughan, W. G. Pentoxifylline protects splanchnic prostacyclin synthesis during mesenteric ischemia/reperfusion. Prostaglandins 47(2): 137-150, 1994.
47. 2 synthesis. Prostaglandins Leukotrienes Essent. Fatty Acids 52(1): 41-48, 1995.
48. Steeb, G. D., Wilson, M. A., and Garrison, R. N. Pentoxifylline preserves small intestine microvascular blood flow during bacteremia. Surgery 112: 756-764, 1992.
49. Doherty, G. M., Jensen, J. C., Alexander, H. R., Buresh, C. M., and Norton, J. A. Pentoxifylline suppression of tumour necrosis factor gene transcription. Surgery 110: 192-198, 1991.
50. Edwards, M. J., Abney, D. L., and Miller, F. N. Pentoxifylline inhibits interleukin-2 induced leukocyte endothelial adherence and reduces systemic toxicity. Surgery 110: 199-204, 1991.
51. Mollitt, D. L., and Poulos, N. D. The role of pentoxifylline in endotoxin-induced alterations of red cell deformability and whole blood viscosity in the neonate. J. Pediatr. Surg. 26: 572-574, 1991.
52. Bessler, H., Gilgal, R., Djaldetti, M., and Zahavi, I. Effect of pentoxifylline on the phagocytic activity, cAKP levels, andsuperoxide anion production by monocytes and polymorphonuclear cells. J. Leukocyte Biol. 40: 747-754, 1986.
53. Akopov, S. E., and Gabrielian, E. S. The relationship between the degradation of prostacyclin in blood and antiplatelet drug effects in patients with atherosclerosis. J. Clin. Pharmacol. 33(11): 1048-1051, 1993.
54. Myers, S. I., Hernandez, R., and Horton, J. W. Endotoxic shock has differential effects on renal and splanchnic eicosanoid synthesis. Prostaglandins Leukotrienes Essent. Fatty Acids 49(1): 509-513, 1993.
55. Sinha, B., Semmler, J., Eisenhut, T., Eigler, A., and Endres, S. Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation of phosphodiesterase inhibitors and prostanoids. Eur. J. Immunol. 25(1): 147-153, 1995.
56. Wang, P., Ba, Z. F., Stepp, K J., and Chaudry, I. H. Pentoxifylline attenuates the depressed endothelial cell function and vascular smooth muscle contractility following trauma and hemorrhagic shock. J. Trauma 39(1): 121-127, 1995.