The induction of a biphasic bronchospasm by the ET(B) agonist, IRL 1620, due to thromboxane A2 generation and endothelin-1 release in guinea-pigs

British Journal of Pharmacology

Volumn 118, Issue 6, 1996, Pages 1397-1402

  Noguchi, Seiji ^a   Kashihara, Yasunari ^b   Bertrand, Claude ^a  

^a CIBA GEIGY LTD   (Switzerland)

^b Optoelectronics R and D Laboratories   (Japan)

Author keywords

Autocrine release of ET 1; BQ 123; BQ 788; Bronchoconstriction; ET(B) selective agonist; IRL 1620; Phosphoramidon; Thromboxane A2 (TXA2)

Indexed keywords

ACETYLCHOLINE; ATROPINE; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; ENDOTHELIN RECEPTOR; MEMBRANE METALLOENDOPEPTIDASE; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 2 RECEPTOR ANTAGONIST; NOLPITANTIUM; OZAGREL; PHOSPHORAMIDON; PRANLUKAST; SAREDUTANT; SUCCINYLENDOTHELIN 1 [8-21][9 GLUTAMIC ACID 11,15 ALANINE]; THROMBOXANE A2;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; BRONCHOSPASM; CHOLINERGIC NERVE; CONTROLLED STUDY; FEMALE; GUINEA PIG; LUNG COMPLIANCE; LUNG RESISTANCE; MALE; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE;

EID: 0029948157     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15551.x     Document Type: Article

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