The human papillomavirus E6/E7 genes induce discordant changes in the expression of cell growth regulatory proteins

Carcinogenesis

Volumn 17, Issue 7, 1996, Pages 1395-1401

  Pei, Xu Fang ^a,b  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN A; CYCLIN B; INVOLUCRIN; MYC PROTEIN; ONCOPROTEIN; PROTEIN P53; REGULATOR PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL GROWTH; CELL IMMORTALIZATION; HUMAN; HUMAN CELL; KERATINOCYTE; MALE; MOUSE; NONHUMAN; PREPUCE; PRIORITY JOURNAL; VIRUS ONCOGENE; WART VIRUS;

APOPTOSIS; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; CYCLINS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, VIRAL; HUMANS; KERATINOCYTES; MALE; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PROTO-ONCOGENE PROTEINS C-MYC; REPRESSOR PROTEINS; SKIN; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0029947669     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.7.1395     Document Type: Article

References (40)

1. Werness, B.A., Levine, A.J. and Howley, P.M. (1990) Association of human papillomavirus types 16 and 18 E6 protein with p53. Science, 248, 76-79.
2. Dyson, N., Howley, P.M., Munger, K. and Harlow, E. (1989) The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science, 243, 934-937.
3. Goodrich, D.W., Wang, N.P., Qian, Y.W., Lee, E.Y. and Lee, W.H. (1991) The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell, 67, 293-302.
4. Diller, L., Kassel, J., Nelson, C.E. et al. (1990) p53 functions as a cell cycle control protein in osteosarcomas. Mol. Cell Biol., 10, 5772-5781.
5. Scheffner, M., Werness, B.A., Huibregtse, J.M., Levine, A.J. and Howley, P.M. (1990) The E6 oncoprotein encoded by human papillomavirus 16 and 18 promotes the degradation of p53. Cell, 63, 1129-1136.
6. Pagano, M., Durst, M., Joswig, S., Draetta, G. and Jansen-Durr, P. (1992) Binding of human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells. Oncogene, 7, 1681-1686.
7. Nevins, J.R. (1992) E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science, 258, 424-429.
8. Farnham, P.J., Slanky, J.E. and Kollmar, R. (1993) The role of E2F in the mammalian cell cycle. Biochim. Biophys. Acta, 1155, 125-131.
9. Ludlow, J.W. (1993) Interactions between SV40 large-tumor antigen and the growth suppressor proteins pRB and p53. FASEB J., 7, 866-871.
10. Moran, E. (1993) Interactions of adenoviral proteins with pRB and p53. FASEB J., 7, 880-885.
11. Smith, P.P., Bryant, E.M., Kaur, P. and McDougall, J.K. (1989) Cytogenetic analysis of eight human papillomavirus immortalized keratinocyte cell lines. Int. J. Cancer, 44, 1124-1131.
12. Barbosa, M.S. and Schlegel, R. (1989) The E6 and E7 genes of HPV-18 are sufficient for inducing two-stage in vitro transformation of human keratinocytes. Oncogene, 4, 1529-1532.
13. Davies, R., Hicks, R., Crook, T., Morris, J. and Vousden, K.H. (1993) Human papillomavirus type-16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation. J. Virol., 67, 2521-2528.
14. Hu, T.H., Ferril, S.C., Snider, A.M. and Barbosa, M.S. (1995) In vivo analysis of HPV E7 protein association with pRb, p107, and p130. Int. J. Oncol., 6, 167-174.
15. CDK2 and cyclin A. Oncogene, 8, 195-202.
16. Steinmann, K., Pei, X.F., Stoppler, H., Schlegel, R. and Schlegel, R. (1994) Alevated expression and activity of mitotic regulatory proteins in human papillomavirus-immortalized keratinocytes. Oncogene, 9, 397-394.
17. Miller, A.D. and Rosman, G.J. (1989) Improved retroviral vectors for gene transfer and expression. BioTechniques, 7, 980-990.
18. Schlegel, R., Phelps, W.C., Zhang, Y.L. and Barbosa, M. (1988) Quantitative keratinocyte assay detects two biological activities of human papillomavirus DNA and identifies viral types associated with cervical carcinoma. EMBO J., 7, 3181-3187.
19. Davis, L.G., Dibner, M.D. and Battey, J.F. (1986) Basic Methods in Molecular Biology. Elsevier, Amsterdam.
20. 34cdc2. Cell. 58, 833-846.
21. Pines, J. and Hunter, T (1990) Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature, 346, 760-762.
22. Lee, M.G. and Nurse, P. (1987) Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. Nature, 327, 31-35.
23. Baker, S.J., Markowitz, S., Fearon, E.R., Willson, J.K.V. and Vogelstein, B. (1990) Suppression of human colorectal carcinoma cell growth by wild-type p53. Science, 249, 912-915.
24. Villa, L.L. and Schlegel, R. (1991) Differences in transformation activity between HPV-18 and HPV-16 map to the viral LCR-E6-E7 region. Virology, 181, 474-477.
25. Eckert, R.L. and Green, H. (1986) Structure and evolution of the human involucrin gene. Cell, 46, 583-589.
26. Laborda, J. (1991) 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nucleic Acids Res., 19, 3998.
27. Pietenpol, J.A. Holt, J.T., Stein, R.W. and Moses, H.L. (1990) Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation. Proc. Natl Acad. Sci. USA, 87, 3785-3762.
28. Pietenpol, J.A., Stein, R.W., Moran, E. et al. (1990) TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. Cell, 61, 777-785.
29. Donehower, L.A. and Bradley, A. (1993) The tumor suppressor p53. Biochim. Biophys. Acta, 1155, 181-205.
30. Huibregtse, J.M., Scheffner, M. and Howley, P.M. (1991) A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus type 16 or 18. EMBO J., 10, 4129-4135.
31. Hubbert, N.L., Sedman, S.A. and Schiller, J.T. (1992) Human papillomavirus type 16 E6 increases the degradation rale of p53 in human keratinocytes. J. Virol., 66, 6237-6241.
32. Pei, X.F., Sherman, L., Sun, Y.H. and Schlegel, R. (1996) HPV-16 E7 protein bypasses keratinocyte growth inhibition by serum and calcium. (submitted).
33. Korsmeyer, S.J. (1992) bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood, 80, 879-886.
34. Bissonette, R.P., Echeverri, F., Mahboubi, A. and Green, D.R. (1992) Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature, 359, 552-554.
35. Hartwell, L.H. (1991) Role of yeast in cancer research. Accomplishments in Cancer Research. pp. 105-116.
36. Hartwell, L.H. (1992) Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer. Cell, 71, 543-546.
37. Hartwell, L.H. and Kastan, M.B. (1994) Cell cycle control and cancer. Science, 266, 1821-1828.
38. Pitot, H.C. (1993) The molecular biology of carcinogenesis. Cancer, 72, 962-970.
39. Durst, M. Kleinheinz, A., Hotz, M. and Gissman, L. (1985) The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumors. J. Gen. Virol., 66, 1515-1522.
40. Pirisi, L., Yasumoto, S., Feller, M., Doniger, J. and DiPaolo, J.A. (1987) Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. J. Virol., 61, 1061-1066.