Gene transfer of multidrug resistance into a factor-dependent human hematopoietic progenitor cell line: In vivo model for genetically transferred chemoprotection

Blood

Volumn 87, Issue 7, 1996, Pages 2723-2731

  Schwarzenberger, Paul ^a   Spence, Sally ^a   Lohrey, Nancy ^a   Kmiecik, Thomas ^a   Longo, Dan L ^a   Murphy, William J ^a   Ruscetti, Francis W ^a   Keller, Jonathan R ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CD34 ANTIGEN; COMPLEMENTARY DNA; GENE PRODUCT; PACLITAXEL;

ANIMAL MODEL; ARTICLE; BONE MARROW CELL; BONE MARROW SUPPRESSION; CANCER; CANCER CHEMOTHERAPY; CELL TRANSPLANTATION; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION; GENE TRANSFER; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS;

EID: 0029947434     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.7.2723.bloodjournal8772723     Document Type: Article

References (22)

1. Ueda K, Cardarelli C, Gottesman M, Pastan I: Expression of a full length cDNA for the human MDR1 gene confers resistance to colchicine, doxorubicine, and vinblastine. Proc Natl Acad Sci USA 84:3004, 1987
2. Boesen JJB, Nooter K, Valerio D: Circumvention of chemotherapy-induced myelosuppression by transfer of the mdr1 gene. Biotherapy 6:291, 1994
3. Mickisch G, Merlino G, Galski H, Pastan I: Transgenic mice that express the human multidrug-resistance in bone marrow enable a rapid identification of agents that reverse drug resistance. Proc Natl Acad Sci USA 88:547, 1991
4. Mickisch G, Arsentijevich I, Schoenlein P, Goldstein LJ, Galski H, Stahle C, Sachs DH, Pastan I, Gottesman MM: Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice. Blood 79:1087, 1992
5. Sorrentino BP, Brandt SJ, Bodine D, Nienhuis AW: Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1. Science 257:99, 1992
6. Podda S, Ward M, Himelstein A, Bank A: Transfer and expression of the human multiple drug resistance gene into live mice. Proc Natl Acad Sci USA 89:9676, 1992
7. + cells. Blood 84:1408, 1994
8. Hesdorfer C, Amman K. Bank A: Human MDR gene transfer in patients with advanced cancer. Human Gene Therapy 5:1151, 1994
9. Deisseroth A, Hanania E, Siqing F: American Society of Clinical Oncology, Chicago, IL, Educational Book, 31st Annual Meeting 1995, p 272
10. Avanzi GC, Lista P, Giovinazzo B, Pegoraro L: Selective growth response to IL-3 of a human leukaemic cell line with megakaryoblastic features. Br J Haematol 69:359, 1988
11. Avanzi GZ, Brizzi MF, Gianotti J, Clark SC: M-O7e Human leukemic factor-dependent cell line provides a rapid and sensitive bioassay for the human cytokines GM-CSF and IL-3. J Cell Physiol Suppl 145:458, 1990
12. Pastan I, Gottesman MM, Ueda K, Lovelace E, Rutherford AV, Willingham MC: A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proc Natl Acad Sci USA 85:4486, 1988
13. Markowitz D, Goff S, Bank A: Construction and use of a safe and efficient amphotropic packaging cell line. Virology 167:400, 1988
14. Mickisch GH, Pai LH, Pastan I: Monoclonal antibody MRK16 reverses the multidrug resistance of multidrug resistant transgenic mice. Cancer Res 52:4427, 1991
15. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1989, p 7.19
16. Shultz LD, Schweitzer PA, Christianson S, Gott B, Schweitzer IB, Leiter E: Multiple defects in innate and adaptive immunologie function in NOD/LtSz-scid mice. J Immunol 154:180, 1995
17. Cassel A, Cottler-Fox M, Doren S, Dunbar CE: Retroviral-mediated gene transfer into CD34-enriched human peripheral blood stem cells. Exp Hematol 21:585, 1993
18. Peters WP, Shpall EJ, Jones RB, Olsen GA, Bast RC, Gockerman JP: High dose combination alkylating agents with bone marrow support as initial treatment for metastatic breast cancer. J Clin Oncol 6:1368, 1988
19. Appelbaum FR, Sullivan KM, Buckner CD: Treatment of malignant lymphoma in 100 patients with chemotherapy, total body irradiation, and bone marrow transplantation. J Clin Oncol 4:1340, 1987
20. Gale RP: Myelosuppressive effects of antineoplastic chemotherapy, in Testa NG (ed): Hematopoiesis: Long-term Effects of Chemotherapy and Radiation. New York, NY, Dekker, 1988, p 63
21. Tang-Wai D, Kajiji S, Di Capua F, Gros P: Human (MDR1) and mouse (mdr1 and mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators. Biochemistry 34:32, 1995
22. Chabner B: Anticancer drugs, in De Vita VT, Hellmann S, Rosenberg SA (eds): Cancer, Principles and Practice of Oncology. Philadelphia, PA, Lippincott, 1993, p 414