메뉴 건너뛰기




Volumn 74, Issue 3, 1996, Pages 127-134

IL-2 gene therapy of solid tumors: An approach for the prevention of signal transduction defects in T cells

Author keywords

Gene therapy; Immune suppression; Interleukin 2; Signal transduction; T Cells

Indexed keywords

INTERLEUKIN 2;

EID: 0029947360     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01575444     Document Type: Review
Times cited : (14)

References (79)
  • 1
    • 0028298850 scopus 로고
    • A new look for the 1990s
    • Pardoll D (1994) A new look for the 1990s. Nature 369:357-358
    • (1994) Nature , vol.369 , pp. 357-358
    • Pardoll, D.1
  • 2
    • 0028298224 scopus 로고
    • Cancer antigens: Immune recognition of self and altered self
    • Houghton AN (1994) Cancer antigens: immune recognition of self and altered self. J Exp Med 180:1-4
    • (1994) J Exp Med , vol.180 , pp. 1-4
    • Houghton, A.N.1
  • 6
    • 0027982995 scopus 로고
    • Tumor immunogenicity determines the effect of B7-1 costimulation on T cell mediated tumor immunity
    • Chen L, McGowan P, Ashe S, Johnston J, Li Y, Hellstrom I, Hellstrom KE (1994) Tumor immunogenicity determines the effect of B7-1 costimulation on T cell mediated tumor immunity. J Exp Med 179:523-532
    • (1994) J Exp Med , vol.179 , pp. 523-532
    • Chen, L.1    McGowan, P.2    Ashe, S.3    Johnston, J.4    Li, Y.5    Hellstrom, I.6    Hellstrom, K.E.7
  • 7
    • 0027392843 scopus 로고
    • + T cells by B7-transfected melanoma cells
    • + T cells by B7-transfected melanoma cells. Science 259:368-370
    • (1993) Science , vol.259 , pp. 368-370
    • Townsend, S.E.1    Allison, J.2
  • 8
    • 0024773405 scopus 로고
    • Prospect for the treatment of B cell tumors using idiotypic vaccination
    • George AJT, Stevenson FK (1989) Prospect for the treatment of B cell tumors using idiotypic vaccination. Intern Rev Immunol 4:271-310
    • (1989) Intern Rev Immunol , vol.4 , pp. 271-310
    • George, A.J.T.1    Stevenson, F.K.2
  • 9
    • 0027345633 scopus 로고
    • Immunosuppressive factors in human cancers
    • Sulizeanu D (1993) Immunosuppressive factors in human cancers. Adv Cancer Res 60:247-267
    • (1993) Adv Cancer Res , vol.60 , pp. 247-267
    • Sulizeanu, D.1
  • 10
    • 0026693845 scopus 로고
    • MHC antigens and cancer: Implications for T-cell surveillance
    • Browning MJ, Bodmer WF (1992) MHC antigens and cancer: Implications for T-cell surveillance. Curr Opin Immunol 4:613-618
    • (1992) Curr Opin Immunol , vol.4 , pp. 613-618
    • Browning, M.J.1    Bodmer, W.F.2
  • 11
    • 0018236748 scopus 로고
    • The suppressor cell network in cancer
    • Broder S, Waldmann H (1978) The suppressor cell network in cancer. New Engl J Med 299:1281-1284
    • (1978) New Engl J Med , vol.299 , pp. 1281-1284
    • Broder, S.1    Waldmann, H.2
  • 13
    • 0028045991 scopus 로고
    • Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2 secreting tumors
    • Salvadori S, Gansbacher B, Pizzimenti A, Zier K. (1994) Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2 secreting tumors. J Immunol 153:5176-5182
    • (1994) J Immunol , vol.153 , pp. 5176-5182
    • Salvadori, S.1    Gansbacher, B.2    Pizzimenti, A.3    Zier, K.4
  • 14
    • 0027155436 scopus 로고
    • Cancer vaccines
    • Pardoll DM (1993) Cancer vaccines. Immunol Today 14:310-316
    • (1993) Immunol Today , vol.14 , pp. 310-316
    • Pardoll, D.M.1
  • 15
    • 0028081191 scopus 로고
    • Human tumor vaccines and genetic engineering of tumors with cytokine and histocompatibility genes to enhance immunogenicity
    • Rosenthal F, Zier KS, Gansbacher B (1994) Human tumor vaccines and genetic engineering of tumors with cytokine and histocompatibility genes to enhance immunogenicity. Curr Opin Oncol 6:611-615
    • (1994) Curr Opin Oncol , vol.6 , pp. 611-615
    • Rosenthal, F.1    Zier, K.S.2    Gansbacher, B.3
  • 16
    • 0026547056 scopus 로고
    • Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon
    • Letourneur F, Klausner RD (1992) Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon. Science 255:79-82
    • (1992) Science , vol.255 , pp. 79-82
    • Letourneur, F.1    Klausner, R.D.2
  • 17
    • 0022344887 scopus 로고
    • Generation of antigen specific CTL directed against class II molecules expressed by activated T cells
    • Zier KS (1985) Generation of antigen specific CTL directed against class II molecules expressed by activated T cells. J Immunol Methods 84:73-84
    • (1985) J Immunol Methods , vol.84 , pp. 73-84
    • Zier, K.S.1
  • 18
    • 0028294895 scopus 로고
    • The binding and lysis of target cells by cytotoxic lymphocytes: Molecular and cellular aspects
    • Berke G (1994) The binding and lysis of target cells by cytotoxic lymphocytes: molecular and cellular aspects. Ann Rev Immunol 12:735-773
    • (1994) Ann Rev Immunol , vol.12 , pp. 735-773
    • Berke, G.1
  • 20
    • 0024506159 scopus 로고
    • Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway
    • Lindsten T, June CH, Ledbetter JA, Stella GT, Thompson CB (1989) Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244: 339-343
    • (1989) Science , vol.244 , pp. 339-343
    • Lindsten, T.1    June, C.H.2    Ledbetter, J.A.3    Stella, G.T.4    Thompson, C.B.5
  • 21
    • 0027285630 scopus 로고
    • Molecules involved in T cell costimulation
    • Jenkins MK, Johnson JG (1993) Molecules involved in T cell costimulation. Curr Opin Immunol 5:361-367
    • (1993) Curr Opin Immunol , vol.5 , pp. 361-367
    • Jenkins, M.K.1    Johnson, J.G.2
  • 24
    • 0028052808 scopus 로고
    • Cytokine gene transfer in tumor inhibition and tumor therapy: Where are we now?
    • Colombo MP, Forni G (1993) Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now? Immunol Today 15:48-51
    • (1993) Immunol Today , vol.15 , pp. 48-51
    • Colombo, M.P.1    Forni, G.2
  • 27
    • 0027595949 scopus 로고
    • The basic science of gene therapy
    • Mulligan RC (1993) The basic science of gene therapy. Science 260:926-932
    • (1993) Science , vol.260 , pp. 926-932
    • Mulligan, R.C.1
  • 28
    • 0025000864 scopus 로고
    • IL-2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity
    • Gansbacher B, Zier K, Daniels B, Cronin K, Bannerji R, Gilboa E (1990) IL-2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. J Exp Med 172:1217-1224
    • (1990) J Exp Med , vol.172 , pp. 1217-1224
    • Gansbacher, B.1    Zier, K.2    Daniels, B.3    Cronin, K.4    Bannerji, R.5    Gilboa, E.6
  • 30
    • 0027502562 scopus 로고
    • Regression of bladder tumors in mice treated with interleukin 2 gene-modified tumor cells
    • Connor J, Bannerji R, Saito S, Heston W, Fair W, Gilboa E (1993) Regression of bladder tumors in mice treated with interleukin 2 gene-modified tumor cells. J Exp Med 177:1127-1134
    • (1993) J Exp Med , vol.177 , pp. 1127-1134
    • Connor, J.1    Bannerji, R.2    Saito, S.3    Heston, W.4    Fair, W.5    Gilboa, E.6
  • 31
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
    • Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky HI, Brose K, Jackson V, Hamada H, Pardoll D, Mulligan RC (1993) Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci 90:3539-3543
    • (1993) Proc Natl Acad Sci , vol.90 , pp. 3539-3543
    • Dranoff, G.1    Jaffee, E.2    Lazenby, A.3    Golumbek, P.4    Levitsky, H.I.5    Brose, K.6    Jackson, V.7    Hamada, H.8    Pardoll, D.9    Mulligan, R.C.10
  • 32
    • 0027298471 scopus 로고
    • Anti-metastatic vaccination of tumor-bearing mice with two types of IFN-γ gene inserted tumors cells
    • Porgardor A, Bannerji R, Watanabe Y, Feldman M, Gilboa E, Eisenbach L (1993) Anti-metastatic vaccination of tumor-bearing mice with two types of IFN-γ gene inserted tumors cells. J Immunol 150:1458-1470
    • (1993) J Immunol , vol.150 , pp. 1458-1470
    • Porgardor, A.1    Bannerji, R.2    Watanabe, Y.3    Feldman, M.4    Gilboa, E.5    Eisenbach, L.6
  • 33
    • 0024502120 scopus 로고
    • Murine interleukin-4 displays potent anti-tumor activity in vivo
    • Tepper RI, Pattengale PK, Leder P (1989) Murine interleukin-4 displays potent anti-tumor activity in vivo. Cell 57:503-512
    • (1989) Cell , vol.57 , pp. 503-512
    • Tepper, R.I.1    Pattengale, P.K.2    Leder, P.3
  • 35
    • 0025604195 scopus 로고
    • Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long-lasting antitumor immunity
    • Gansbacher B, Bannerji R, Daniels B, Zier K, Cronin K, Gilboa E (1990) Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long-lasting antitumor immunity. Cancer Res 50:7820-7825
    • (1990) Cancer Res , vol.50 , pp. 7820-7825
    • Gansbacher, B.1    Bannerji, R.2    Daniels, B.3    Zier, K.4    Cronin, K.5    Gilboa, E.6
  • 38
    • 0025806563 scopus 로고
    • Murine tumor cells transduced with the gene for tumor necrosis factor alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors
    • Asher AL, Mule JJ, Kasid A, Restifo NP, Salo JC, Reichert CM, Jaffe G, Fendly B, Kriegler M, Rosenberg SA (1991) Murine tumor cells transduced with the gene for tumor necrosis factor alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors. J Immunol 146:3227-3234
    • (1991) J Immunol , vol.146 , pp. 3227-3234
    • Asher, A.L.1    Mule, J.J.2    Kasid, A.3    Restifo, N.P.4    Salo, J.C.5    Reichert, C.M.6    Jaffe, G.7    Fendly, B.8    Kriegler, M.9    Rosenberg, S.A.10
  • 40
    • 0026033391 scopus 로고
    • Interleukin 2-dependent activation of tumor-specific cytotoxic T lymphocytes in vivo
    • Ley V, Langlade-Demoyen P, Kourilsky P, Larsson-Scared E-L (1991) Interleukin 2-dependent activation of tumor-specific cytotoxic T lymphocytes in vivo. Eur J Immunol 21:851-854
    • (1991) Eur J Immunol , vol.21 , pp. 851-854
    • Ley, V.1    Langlade-Demoyen, P.2    Kourilsky, P.3    Larsson-Scared, E.-L.4
  • 41
    • 0025852249 scopus 로고
    • Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo
    • Colombo M, Ferrari G, Stoppacciaro A, Parenza M, Rodolfo M, Mavilio F, Parmiani G (1991) Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo. J Exp Med 173:889-897
    • (1991) J Exp Med , vol.173 , pp. 889-897
    • Colombo, M.1    Ferrari, G.2    Stoppacciaro, A.3    Parenza, M.4    Rodolfo, M.5    Mavilio, F.6    Parmiani, G.7
  • 42
    • 0026772066 scopus 로고
    • Interleukin-6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers therapeutic competence against metastatic cells
    • Porgador A, Tzehoval E, Katz A, Vadai E, Revel M, Feldman M, Eisenbach L. (1992) Interleukin-6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers therapeutic competence against metastatic cells. Cancer Res 52:3679-3686
    • (1992) Cancer Res , vol.52 , pp. 3679-3686
    • Porgador, A.1    Tzehoval, E.2    Katz, A.3    Vadai, E.4    Revel, M.5    Feldman, M.6    Eisenbach, L.7
  • 43
    • 0028867445 scopus 로고
    • B7-1 transfected tumor cells induce a response in syngeneic hosts in vivo, but fail to stimulate naive allogeneic cells in vitro
    • Salvadori, S, Gansbacher, B, Wernick, I, Tirelli, S, Zier, K (1995) B7-1 transfected tumor cells induce a response in syngeneic hosts in vivo, but fail to stimulate naive allogeneic cells in vitro. Human Gene Ther 6:1299-1306
    • (1995) Human Gene Ther , vol.6 , pp. 1299-1306
    • Salvadori, S.1    Gansbacher, B.2    Wernick, I.3    Tirelli, S.4    Zier, K.5
  • 44
  • 45
    • 0024389426 scopus 로고
    • Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor-mediated activation
    • Sanders ME, Makgoba MW, June CH, Young HA, Shaw S (1989) Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor-mediated activation. Eur J Immunol 19:803-807
    • (1989) Eur J Immunol , vol.19 , pp. 803-807
    • Sanders, M.E.1    Makgoba, M.W.2    June, C.H.3    Young, H.A.4    Shaw, S.5
  • 46
    • 0028057792 scopus 로고
    • The role of tyrosine kinases and phosphotyrosine-containing recognition motifs in regulation of the T cell-antigen receptor mediated signal transduction pathway
    • Isakov N, Wange RL, Samelson LE (1994) The role of tyrosine kinases and phosphotyrosine-containing recognition motifs in regulation of the T cell-antigen receptor mediated signal transduction pathway. J Leuk Biol 55:265-271
    • (1994) J Leuk Biol , vol.55 , pp. 265-271
    • Isakov, N.1    Wange, R.L.2    Samelson, L.E.3
  • 47
    • 0027405991 scopus 로고
    • The IL-2 receptor complex: Its function, and target genes
    • Minami T, Kono T, Miyazaki T, Taniguehi T (1993) The IL-2 receptor complex: its function, and target genes. Ann Rev Immunol 11:245-268
    • (1993) Ann Rev Immunol , vol.11 , pp. 245-268
    • Minami, T.1    Kono, T.2    Miyazaki, T.3    Taniguehi, T.4
  • 48
    • 0026448369 scopus 로고
    • Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor
    • Samelson LE, Klausner RD (1992) Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor. J Biol Chem 267:24913-24916
    • (1992) J Biol Chem , vol.267 , pp. 24913-24916
    • Samelson, L.E.1    Klausner, R.D.2
  • 49
    • 0028535120 scopus 로고
    • ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells
    • van Oers S, Killeen N, Weiss A (1994) ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells. Immunity 1:675-685
    • (1994) Immunity , vol.1 , pp. 675-685
    • Van Oers, S.1    Killeen, N.2    Weiss, A.3
  • 50
    • 0030584925 scopus 로고    scopus 로고
    • The molecular basis of T cell dysfunction in cancer is influenced by paracrine secretion of tumor-derived IL-2
    • in press
    • Salvadori S, Zier K (1996) The molecular basis of T cell dysfunction in cancer is influenced by paracrine secretion of tumor-derived IL-2. J Immunol (in press)
    • (1996) J Immunol
    • Salvadori, S.1    Zier, K.2
  • 51
    • 0028014460 scopus 로고
    • Signal transduction by lymphocyte antigen receptors
    • Weiss A, Littman DR (1994) Signal transduction by lymphocyte antigen receptors. Cell 76:263-274
    • (1994) Cell , vol.76 , pp. 263-274
    • Weiss, A.1    Littman, D.R.2
  • 53
    • 0026669001 scopus 로고
    • Defective T cell receptor signaling in mice lacking the thymic isoform of p59-fyn
    • Appelby MW, Gross JA, Cooke, MP Levin SD, Qian X, Perlmutter RM (1992) Defective T cell receptor signaling in mice lacking the thymic isoform of p59-fyn. Cell 70:751-763
    • (1992) Cell , vol.70 , pp. 751-763
    • Appelby, M.W.1    Gross, J.A.2    Cooke, M.P.3    Levin, S.D.4    Qian, X.5    Perlmutter, R.M.6
  • 54
    • 0026483786 scopus 로고
    • ZAP-70: A 70 kD protein-tyrosinase that associates with the TCR ζ chain
    • Chan AC, Iwashima M, Turck CW, Weiss A (1992) ZAP-70: a 70 kD protein-tyrosinase that associates with the TCR ζ chain. Cell 71:649-662
    • (1992) Cell , vol.71 , pp. 649-662
    • Chan, A.C.1    Iwashima, M.2    Turck, C.W.3    Weiss, A.4
  • 55
    • 0027328526 scopus 로고
    • Tandem SH2 domains of ZAP-70 bind to the T cell antigen receptor zeta and CDε from activated Jurkat T cells
    • Wange RL, Malek SN, Desiderio S, Samelson LE (1993) Tandem SH2 domains of ZAP-70 bind to the T cell antigen receptor zeta and CDε from activated Jurkat T cells. J Biol Chem 268: 19797-19801
    • (1993) J Biol Chem , vol.268 , pp. 19797-19801
    • Wange, R.L.1    Malek, S.N.2    Desiderio, S.3    Samelson, L.E.4
  • 57
    • 0028292001 scopus 로고
    • Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
    • Elder ME, Lin D, Clever J, Chan AC, Hope TJ, Weiss A, Parslow TE (1994) Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 264:1596-1599
    • (1994) Science , vol.264 , pp. 1596-1599
    • Elder, M.E.1    Lin, D.2    Clever, J.3    Chan, A.C.4    Hope, T.J.5    Weiss, A.6    Parslow, T.E.7
  • 59
    • 0028308191 scopus 로고
    • The src-family kinase, fyn, regulates the activation of phosphatidylinositol-3-kinase in an IL-2 dependent line
    • Karnitz LM, Sutor SL, Abraham RT (1994) The src-family kinase, fyn, regulates the activation of phosphatidylinositol-3-kinase in an IL-2 dependent line. J Exp Med 179:1799-1808
    • (1994) J Exp Med , vol.179 , pp. 1799-1808
    • Karnitz, L.M.1    Sutor, S.L.2    Abraham, R.T.3
  • 60
    • 0028021879 scopus 로고
    • Interleukin-2 and the Interleukin-2 receptor complex
    • Samelson LE (ed) Karger, Basel
    • Gaulton GN, Williamson P (1994) Interleukin-2 and the Interleukin-2 receptor complex. In: Samelson LE (ed) Lymphocyte activation. Karger, Basel, pp 91-114
    • (1994) Lymphocyte Activation , pp. 91-114
    • Gaulton, G.N.1    Williamson, P.2
  • 61
    • 0028118512 scopus 로고
    • Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells
    • Truitt KE, Hicks CM, Imboden JB (1994) Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells. J Exp Med 179:1071-1076
    • (1994) J Exp Med , vol.179 , pp. 1071-1076
    • Truitt, K.E.1    Hicks, C.M.2    Imboden, J.B.3
  • 62
    • 0028342859 scopus 로고
    • CD28 of T lymphocytes associates with Pl 3-kinase
    • August A, Dupont B (1994) CD28 of T lymphocytes associates with Pl 3-kinase. Int Immunol 6:769-774
    • (1994) Int Immunol , vol.6 , pp. 769-774
    • August, A.1    Dupont, B.2
  • 65
    • 85012608891 scopus 로고
    • Mechanisms of interleukin 2 action: IL-2-inducible gene expression in T lymphocytes
    • Smith KA (ed)
    • Reed JC, Nowell PC (1988) Mechanisms of interleukin 2 action: IL-2-inducible gene expression in T lymphocytes. In: Smith KA (ed) Interleukin 2, pp 137-151
    • (1988) Interleukin , vol.2 , pp. 137-151
    • Reed, J.C.1    Nowell, P.C.2
  • 67
    • 0028244396 scopus 로고
    • Involvement of the Jak-3 kinase in signaling by interleukins 2 and 4 in lymphoid and myeloid cells
    • Witthuhn BA, Silvennoinen O, Miura O, Lai KS, Cwik C, Liu KT, Ihle JN (1994) Involvement of the Jak-3 kinase in signaling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153-157
    • (1994) Nature , vol.370 , pp. 153-157
    • Witthuhn, B.A.1    Silvennoinen, O.2    Miura, O.3    Lai, K.S.4    Cwik, C.5    Liu, K.T.6    Ihle, J.N.7
  • 68
    • 0028029813 scopus 로고
    • Activation of JAK kinases and STAT proteins by interleukin-2 and interferon α, but not the T cell antigen receptor, in human T lymphocytes
    • Beadling C, Guschin D, Witthuhn BA, Ziemiecki A, Ihle JN, Kerr IM, Cantrell DA (1994) Activation of JAK kinases and STAT proteins by interleukin-2 and interferon α, but not the T cell antigen receptor, in human T lymphocytes. EMBO J 13: 5605-5615
    • (1994) EMBO J , vol.13 , pp. 5605-5615
    • Beadling, C.1    Guschin, D.2    Witthuhn, B.A.3    Ziemiecki, A.4    Ihle, J.N.5    Kerr, I.M.6    Cantrell, D.A.7
  • 69
    • 0028964916 scopus 로고
    • Identification and purification of human Stat proteins activated in response to interleukin-2
    • Hou H, Schindler U, Henzel WJ, Wong SC, McKnight SL (1995) Identification and purification of human Stat proteins activated in response to interleukin-2. Immunity 2:321-329
    • (1995) Immunity , vol.2 , pp. 321-329
    • Hou, H.1    Schindler, U.2    Henzel, W.J.3    Wong, S.C.4    McKnight, S.L.5
  • 70
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell JE, Kerr IM, Stark GR (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell, J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 73
    • 0028568628 scopus 로고
    • The decreased expression of CD3 ζ chains in cancer patients is not reversed by IL-2 administration
    • Farace F, Angevin E, Vanderplancke J, Escudier B, Triebel F (1994) The decreased expression of CD3 ζ chains in cancer patients is not reversed by IL-2 administration. Int J Cancer 59:752-755
    • (1994) Int J Cancer , vol.59 , pp. 752-755
    • Farace, F.1    Angevin, E.2    Vanderplancke, J.3    Escudier, B.4    Triebel, F.5
  • 74
    • 0028965830 scopus 로고
    • Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex
    • Aoe T, Okamoto Y, Saito T (1995) Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex. J Exp Med 181:1881-1886
    • (1995) J Exp Med , vol.181 , pp. 1881-1886
    • Aoe, T.1    Okamoto, Y.2    Saito, T.3
  • 76
  • 77
    • 0028511078 scopus 로고
    • Functional differences are associated with abnormal signal transduction in T cells of mice inoculated with parental but not IL-2 secreting tumor cells
    • Salvadori S, Gansbacher B, Zier KS (1994) Functional differences are associated with abnormal signal transduction in T cells of mice inoculated with parental but not IL-2 secreting tumor cells. Cancer Gene Ther 1:165-170
    • (1994) Cancer Gene Ther , vol.1 , pp. 165-170
    • Salvadori, S.1    Gansbacher, B.2    Zier, K.S.3
  • 78
    • 0030026798 scopus 로고
    • Preventing abnormalities in signal transduction of T cells in cancer: The promise of cytokine gene therapy
    • Zier K, Gansbacher B, Salvadori S (1995) Preventing abnormalities in signal transduction of T cells in cancer: the promise of cytokine gene therapy. Immunol Today 17:39-45
    • (1995) Immunol Today , vol.17 , pp. 39-45
    • Zier, K.1    Gansbacher, B.2    Salvadori, S.3
  • 79
    • 0025343120 scopus 로고
    • Naive and memory T cell show distinct pathways of lymphocyte recirculation
    • Mackay CR, Marston WL, Dudler L (1990) Naive and memory T cell show distinct pathways of lymphocyte recirculation. J Exp Med 171:801-817
    • (1990) J Exp Med , vol.171 , pp. 801-817
    • Mackay, C.R.1    Marston, W.L.2    Dudler, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.