The limiting radiosensitisation of tumours by S-phase sensitisers

British Journal of Cancer

Volumn 74, Issue SUPPL. XXVII, 1996, Pages

  Fowler, J F ^a,b,c   Kinsella, T J ^b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c NONE   (United Kingdom)

Author keywords

BUdR; IUdR; Labelling indices; S phase sensitiser; Sensitiser enhancement ratio

Indexed keywords

RADIOSENSITIZING AGENT; THYMIDINE DERIVATIVE; DNA;

CANCER CONTROL; CANCER SURVIVAL; CELL CYCLE S PHASE; COLON CANCER; CONFERENCE PAPER; CONTROLLED STUDY; DNA SYNTHESIS; DRUG TOLERABILITY; DRUG UPTAKE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIOSENSITIZATION; TUMOR CELL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL SURVIVAL; DRUG EFFECT; RADIATION EXPOSURE;

CELL SURVIVAL; DNA; HUMANS; RADIATION-SENSITIZING AGENTS; S PHASE; TUMOR CELLS, CULTURED;

EID: 0029947035     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (13)

1. BAGSHAW MA, DOGGETT RL, SMITH KC, KAPLAN HS AND NELSEN TS. (1967). Intra-arterial bromodeoxyuridine and x-ray therapy. Radiology, 99, 886-894.
2. EPSTEIN AH, LEBOVICS RS, GOFFMAN T, TEAGUE D, FUETSCH EF, GLATSTEIN EJ, OKUNIEFF P AND COOK JA. (1994). Treatment of locally advanced cancer of the head and neck with 5′-iododeoxyuridine and hyperfractionated radiation therapy: measurement of cell labelling and thymidine replacement. J. Natl Cancer Inst., 86, 1775-1780.
3. KINSELLA TJ, COLLINS J, ROWLAND J, KLECKER R, WRIGHT D, KATZ WD, STEINBERG SM AND GLATSTEIN E. (1988). Pharmacology and Phase I/II study of continuous intravenous infusions of iododeoxyuridine and hyperfractionated radiotherapy in patients with glioblastoma multiforme. J. Clin. Oncol., 6, 871-879.
4. LAWRENCE TS, DAVIS MA, MAYBAUM J, STETSON PL AND ENSMINGER WD. (1990). The dependence of halogenated pyrimidine incorporation and radiosensitization on the duration of drug exposure. Int. J. Radiat. Oncol. Biol. Phys., 18, 1393-1398.
5. MCLAUGHLIN PW, LAWRENCE TS, SEABURY H, NGUYEN N, STETSON PL, GREENBERG HS AND MANCINI WR. (1994). Int. J. Radiat. Oncol. Biol. Phys., 30, 601-607.
6. MILLER EM, FOWLER JL AND KINSELLA TJ. (1992). Radiosensitisation by halogenated pyrimidines: I. Radiosensitization of human colon cancer cells by iododeoxyuridine. Radiat. Res., 131, 81-89.
7. PHILLIPS TL, LEVIN VA, AHN DK, GUTIN PH, DAVIS RL, WILSON CB, PRADOS MD, WARA WM AND FLAM MS. (1991). Evaluation of bromodeoxyuridine in glioblastoma multiforme: a Northern California Cancer Center Phase II study. Int. J. Radiat. Oncol. Biol. Phys., 21, 709-714.
8. RODRIGUEZ R, MILLER E, FOWLER JF AND KINSELLA TJ. (1991). Continuous infusion of halogenated pyrimidines. Int. J. Radiat. Oncol. Biol. Phys., 21, 859-862.
9. SULLIVAN FJ, HERSCHER LL, COOK JA, SMITH J, STEINBERG SM, EPSTEIN AH, OLDFIELD EH, GOFFMAN TE, KINSELLA TJ, MITCHELL JB AND GLATSTEIN E. (1994). National Cancer Institute (Phase II) study of high grade glioma treated with partial brain hyperfractionated radiation and iododeoxyuridine: encouraging results in anaplastic astrocytoma. Int. J. Radiat. Oncol. Biol. Phys., 30, 583-590.
10. URTASUN RC, COSMATOS D, DELROWE J, KINSELLA TJ, LESTER S, WASSERMAN T AND FULTON DS. (1993). Iododeoxyuridine (IUdR) combined with radiation in the treatment of malignant glioma: a comparison of short vs long intravenous dose schedules (RTOG 86-12). Int. J. Radiat. Oncol. Biol. Phys., 27, 207-214.
11. URTASUN RC, KINSELLA TJ, DELROWE J, FARMAN N, LESTER S AND FULTON DS. (1996). Survival improvement in anaplastic astrocytoma combining external radiation with halogenated pyrimidines. Final report of RTOG 86-12 Phase I-II study. Int. J. Radiat. Oncol. Biol. Phys. (in press).
12. WILSON GD, MCNALLY NJ, DISCHE S, SAUNDERS MI, DES ROCHERS C, LEWIS AA AND BENNETT MH. (1988). Measurement of cell kinetics in human tumours in vivo using BUdR incorporation and flow cytometry. Br. J. Cancer, 58, 423-431.
13. WITHERS HR, TAYLOR JMG AND MACIEJEWSKI B. (1988). The hazard of accelerated tumour clonogen repopulation during radiotherapy. Acta Oncol., 27, 131-146.