27-hydroxylated low density lipoprotein (LDL) cholesterol can be converted to 7α,27-dihydroxy-4-cholesten-3-one (cytosterone) before suppressing cholesterol production in normal human fibroblasts: Evidence that an altered metabolism of LDL cholesterol can underlie a defective feedback control in malignant cells

Journal of Biological Chemistry

Volumn 271, Issue 22, 1996, Pages 12724-12736

  Axelson, Magnus ^a   Larsson, Olle ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ARTICLE; AUTOOXIDATION; CANCER CELL; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; FEEDBACK SYSTEM; FIBROBLAST; HUMAN; HUMAN CELL; HYDROXYLATION; PRIORITY JOURNAL;

CELL LINE, TRANSFORMED; CHOLESTENONES; CHOLESTEROL; CHOLESTEROL, LDL; CYTOCHROME P-450 CYP27A1; CYTOCHROME P-450 ENZYME SYSTEM; FIBROBLASTS; HUMANS; HYDROXYLATION; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; OXYGEN; STEROID HYDROXYLASES; TUMOR CELLS, CULTURED;

EID: 0029946926     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.22.12724     Document Type: Article

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