Mechanisms of satigrel (E5510), a new anti-platelet drug, in inhibiting human platelet aggregation. Selectivity and potency against prostaglandin H synthases isozyme activities and phosphodiesterase isoform activities

Biological and Pharmaceutical Bulletin

Volumn 19, Issue 6, 1996, Pages 828-833

  Nagakura, Naoki ^a   Saeki, Takao ^a   Harada, Koukichi ^a   Yoshitake, Shinji ^a   Kobayashi, Seiichi ^a   Yamanaka, Takashi ^a   Saito, Isao ^a  

^a EISAI CO LTD   (Japan)

Author keywords

anti platelet aggregating agent; phosphodiesterase; platelet; prostaglandin H synthase; satigrel

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; CILOSTAZOL; COLLAGEN; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; DIPYRIDAMOLE; INDOMETACIN; ISOENZYME; ITAZIGREL; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PAPAVERINE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PROSTAGLANDIN SYNTHASE; SATIGREL; THROMBIN; THROMBOXANE A2; ZAPRINAST;

ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; INFLAMMATION; THROMBOCYTE AGGREGATION; THROMBOSIS;

EID: 0029946581     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.19.828     Document Type: Article

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