Capillary leakage of a macromolecular MRI agent, carboxymethyldextran-Gd-DPTA, in the liver: pharmacokinetics and imaging implications

Magnetic Resonance Imaging

Volumn 14, Issue 4, 1996, Pages 381-390

  Siauve, Nathalie ^a   Clément, Olivier ^a   Cuénod, Charles André ^a   Benderbous, Soraya ^b   Frija, Guy ^a  

^a Faculté de Médecine Necker   (France)

^b Laboratoire Guerbet   (France)

Author keywords

Capillary permeability; Gadolinium; Lymph; Macromolecular contrast agent; Magnetic resonance (MR) contrast enhancement

Indexed keywords

ORYCTOLAGUS CUNICULUS; ANIMALIA;

CARBOXYMETHYLDEXTRAN; CONTRAST MEDIUM; GADOLINIUM PENTETATE; GADOTERIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CAPILLARY PERMEABILITY; CONTRAST ENHANCEMENT; CONTRAST MEDIUM EXTRAVASATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG LYMPH LEVEL; EXCHANGE BLOOD TRANSFUSION; EXTRACELLULAR SPACE; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MACROMOLECULE; NEPHRECTOMY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RABBIT;

ANIMALS; CAPILLARY PERMEABILITY; CONTRAST MEDIA; FEMALE; GADOLINIUM DTPA; HETEROCYCLIC COMPOUNDS; LIVER; LYMPH; MACROMOLECULAR SUBSTANCES; MAGNETIC RESONANCE IMAGING; ORGANOMETALLIC COMPOUNDS; PENTETIC ACID; RABBITS;

EID: 0029946237     PISSN: 0730725X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0730-725X(96)00020-3     Document Type: Article

References (26)

1. Schmiedl, U.; Moseley, M.E.; Ogan, M.D.; Chew, W.M.; Brasch, R.C. Comparison of initial biodistribution patterns of Gd-DTPA and albumin-(Gd-DTPA) using rapid spin echo MR imaging. JCAT 11:306-313; 1987.
2. Schmiedl, U.; Ogan, M.D.; Moseley, M.E.; Brasch, R.C. Comparison of the contrast-enhancing properties of albumin-(Gd-DTPA) and Gd-DTPA at 2.0 T: An experimental study in rats. AJR 147:1263-1270; 1986.
3. Van Hecke, P.; Marchal, G.; Bosmans, H.; Johannik, K.; Jiang, Y.; Vogler, H.; Van Ongeval, C.; Baert, A.L.; Speck, U. NMR imaging study of the pharmacodynamics of polylysine-gadolinium-DTPA in the rabbit and the rat. Magn. Reson. Imaging 9:313-321; 1991.
4. Schuhmann-Giampieri, G.; Schmitt-Willich, H.; Frenzel, T.; Press, W.; Weinmann, H. In vivo and in vitro evaluation of Gd-DTPA-polylysine as a macromolecular contrast agent for magnetic resonance imaging. Invest. Radiol. 26:969-974; 1991.
5. Li, K.C.P.; Quisling, R.G.; Armitage, F.E.; Richardson, D.; Mladinich, C. In vivo MR evaluation of Gd-DTPA conjugated to dextran in normal rabbits. Magn. Reson. Imaging 10:439-444; 1992.
6. Meyer, D.; Schaefer, M.; Chambon, C.; Beaute, S. Paramagnetic dextrans as magnetic resonance blood pool tracers. Invest. Radiol. 29:S90-S92; 1994.
7. Ranney, D.F.; Weinreb, J.C.; Cohen, J.M.; Srikanthan, S.; King-Breeding, L.; Kulkarni, P.; Antich, P. Gd-DTPA polymers and microspheres for improved enhancement of liver, solid tumors and the cardiovascular blood pool. In: V.M. Runge; C. Claussen; R. Felix; A.E.J. Jamse (Eds). Contrast Agents in Magnetic Resonance Imaging. Amsterdam: Excerpta Medica; 1986: pp. 81-86.
8. Doucet, D.; Urvoas, E.; Kravtzoff, R.; Chambon, C.; Schoumann-Claeys, E.; Frija, G.; Ropars, C. Blood-pool magnetic resonance imaging contrast agents: New developments. Invest. Radiol. 26:S46-S47; 1991.
9. Kravtzoff, R.; Urvoas, E.; Chambon, C.; Ropars, C. Gd-Dota loaded into red blood cells, a new magnetic resonance imaging contrast agents for vascular system. Adv. Exp. Med. Biol. 326:347-354; 1992.
10. Brasch, R.C. Rationale and applications for macromolecular Gd-based contrast agents. Magn. Reson. Med. 22:282-287; 1991.
11. Vexler, V.S.; Berthezène, Y.; Clément, O.; Mühler, A.; Rosenau, W.; Moseley, M.E.; Brasch, R.C. Detection of zonal renal ischemia with contrast-enhanced MR imaging with a macromolecular blood pool contrast agent. J. Magn. Reson. Imaging 2:311-319; 1992.
12. Nugent, L.J.; Jain, R.K. Plasma pharmacokinetics and interstitial diffusion of macromolecules in a capillary bed. Am. J. Physiol. 246:H129-H137; 1984.
13. Shames, D.M.; Kuwatsuru, R.; Vexler, V.; Mühler, A.; Brasch, R.C. Measurement of capillary permeability to macromolecules by dynamic magnetic resonance imaging: A quantitative noninvasive technique. Magn. Reson. Med. 29:616-622; 1993.
14. Bollman, J.L.; Cain, J.C.; Grindlay, J.H. Techniques for the collection of lymph from the liver, small intestine, or thoracic duct of the rat. J. Lab. Clin. Med. 33:1349-1352; 1948.
15. Godart, S.J. Experimental approach to the hepatic lymphatic system. In: B. Anat (Eds). 4th European Conference on Microcirculation. Cambridge: Karger; 1966: pp. 369-373.
16. Goresky, C.A.; Groom, A.C. Microcirculatory events in the liver and the spleen. In: E.M. Renkin; C.C. Michel (Eds). Handbook of Physiology. Bethesda: Am. Physiol. Soc.; 1984: pp. 690-741.
17. Altman, P.L.; Dittmer, D.S. Biology Data Book. Bethesda: Federation of American Societies for Experimental Biology; 1974.
18. Simionescu, N. Cellular aspects of transcapillary exchange. Physiol. Rev. 63:1536-1579; 1983.
19. Simoniescu, M.; Ghitescu, L.; Fixman, A.; Simoniescu, N. How plasma macromolecules cross the endothelium. News Physiol. Sci. 2:97-100; 1987.
20. Goresky, C.A. The nature of transcapillary exchange in the liver. Can. Med. Assoc. J. 92:517-522; 1965.
21. Szabo, G.; Magyar, Z.; Jakab, F. The lymphatic drainage of the liver capsula and hepatic parenchyma. Res. Exp. Med. 166:193-200; 1975.
22. Grotte, G. Passage of dextran molecules across the blood-lymph barrier. Acta Chir. Scand. Suppl. 211: 1956.
23. Gibby, W.A.; Billings, J.; Hall, J.; Ovitt, T.W. Biodistribution and magnetic resonance imaging of cross-linked DTPA polysaccharides. Invest. Radiol. 25:164-172; 1990.
24. Garlick, D.G.; Renkin, E.M. Transport of large molecules from plasma to interstitial fluid and lymph in dogs. Am. J. Physiol. 219:1595-1605; 1970.
25. Casley-Smith, J.R. How the lymphatic system works. Lymphology 1:77-80; 1986.
26. Taylor, A.E.; Granger, N.D. Exchange of macromolecules across the microcirculation. In: E.M. Renkin; C.C. Michel (Eds). Handbook of Physiology. Bethesda: American Physiological Society; 1984: pp. 467-520.