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1
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0026711121
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Drug targeting systems for antiviral agents: Options and limitations
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D.K.F. Meijer, R.W. Jansen and G. Molema, Drug targeting systems for antiviral agents: options and limitations, Antiviral Res. 18 (1992) 215-248.
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(1992)
Antiviral Res.
, vol.18
, pp. 215-248
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Meijer, D.K.F.1
Jansen, R.W.2
Molema, G.3
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2
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0028416237
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Targeting of drugs to various blood cell types using (neo)-glycoproteins, antibodies and other protein carriers
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G. Molema and D.K.F. Meijer, Targeting of drugs to various blood cell types using (neo)-glycoproteins, antibodies and other protein carriers, Adv. Drug Deliv. Rev. 14 (1994) 25-50.
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(1994)
Adv. Drug Deliv. Rev.
, vol.14
, pp. 25-50
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Molema, G.1
Meijer, D.K.F.2
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3
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0024510074
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Covalent and noncovalent protein binding of drugs: Implications for hepatic clearance, storage, and cell-specific drug delivery
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D.K.F. Meijer and P. van der Sluijs, Covalent and noncovalent protein binding of drugs: Implications for hepatic clearance, storage, and cell-specific drug delivery, Pharm. Res. 6 (1989) 105-118.
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(1989)
Pharm. Res.
, vol.6
, pp. 105-118
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Meijer, D.K.F.1
Van Der Sluijs, P.2
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4
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0343642302
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Design of cell-specific drug targeting preparations for the liver: Where cell biology and medicinal chemistry meet
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H. Timmerman and V. Claassen (Eds), The Netherlands
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D.K.F. Meijer, G. Molema, R.W. Jansen and F. Moolenaar, Design of cell-specific drug targeting preparations for the liver: where cell biology and medicinal chemistry meet, in: H. Timmerman and V. Claassen (Eds), Trends in Drug Research, Proceedings of the Seventh Noordwijkerhout-Camerino Symposium, Pharmacochemistry Library Vol. 13, Weesp, The Netherlands, 1990, pp. 303-333.
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(1990)
Trends in Drug Research, Proceedings of the Seventh Noordwijkerhout-camerino Symposium, Pharmacochemistry Library Vol. 13, Weesp
, vol.13
, pp. 303-333
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Meijer, D.K.F.1
Molema, G.2
Jansen, R.W.3
Moolenaar, F.4
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5
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0343642781
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Disposition of macromolecules in the liver in relation to drug targeting
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G.N.J. Tytgat and M. Van Blankenstein (Eds), Georg Thieme Verlag, Stuttgart
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D.K.F. Meijer, R.W. Jansen and G. Molema, Disposition of macromolecules in the liver in relation to drug targeting, in: G.N.J. Tytgat and M. Van Blankenstein (Eds), Current Topics in Gastroenterology and Hepatology, Georg Thieme Verlag, Stuttgart, 1990, pp. 374-392.
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(1990)
Current Topics in Gastroenterology and Hepatology
, pp. 374-392
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Meijer, D.K.F.1
Jansen, R.W.2
Molema, G.3
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6
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0002979228
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Mechanisms for the hepatic clearance of oligopeptides and proteins. Implications for rate of elimination, bioavailability and cell-specific drug delivery
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K.L. Audus and T.J. Raub (Eds), Plenum Press, New York
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D.K.F. Meijer and K. Ziegler, Mechanisms for the hepatic clearance of oligopeptides and proteins. Implications for rate of elimination, bioavailability and cell-specific drug delivery, in: K.L. Audus and T.J. Raub (Eds), Biological Barriers to Protein Delivery, Plenum Press, New York, 1993, pp. 339-407.
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(1993)
Biological Barriers to Protein Delivery
, pp. 339-407
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Meijer, D.K.F.1
Ziegler, K.2
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7
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0008066876
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Hepatic transport of drugs and proteins
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N. McIntyre, J.P. Benhamou, J. Bircher, M. Rizzetto and J. Rodes (Eds), University Press, Oxford
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D.K.F. Meijer and G.M.M. Groothuis, Hepatic transport of drugs and proteins, in: N. McIntyre, J.P. Benhamou, J. Bircher, M. Rizzetto and J. Rodes (Eds), Oxford Textbook of Clinical Hepatology, University Press, Oxford, 1991, pp. 40-78.
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(1991)
Oxford Textbook of Clinical Hepatology
, pp. 40-78
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Meijer, D.K.F.1
Groothuis, G.M.M.2
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8
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0028419623
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Drug targeting to the kidney with low molecular weight proteins
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E.J.F. Franssen, F. Moolenaar, D. de Zeeuw and D.K.F. Meijer, Drug targeting to the kidney with low molecular weight proteins, Adv. Drug Deliv. Rev. 14 (1994) 67-88.
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(1994)
Adv. Drug Deliv. Rev.
, vol.14
, pp. 67-88
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Franssen, E.J.F.1
Moolenaar, F.2
De Zeeuw, D.3
Meijer, D.K.F.4
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9
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0026734164
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Low molecular weight proteins as carriers for renal drug targeting. Preparation of drug-protein conjugates, spacer derivatives of model drugs and their catabolism in renal cortex homogenates and lysosomal lysates
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E.J.F. Franssen, J. Koiter, C.A.M. Kuipers, A.P. Bruins, F. Moolenaar, D. de Zeeuw, W.H. Kruizinga, R.M. Kellogg and D.K.F. Meijer, Low molecular weight proteins as carriers for renal drug targeting. Preparation of drug-protein conjugates, spacer derivatives of model drugs and their catabolism in renal cortex homogenates and lysosomal lysates, J. Med. Chem. 35 (1992) 1246-1259.
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(1992)
J. Med. Chem.
, vol.35
, pp. 1246-1259
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Franssen, E.J.F.1
Koiter, J.2
Kuipers, C.A.M.3
Bruins, A.P.4
Moolenaar, F.5
De Zeeuw, D.6
Kruizinga, W.H.7
Kellogg, R.M.8
Meijer, D.K.F.9
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10
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0025741715
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Low molecular weight proteins as carriers for renal drug targeting: Naproxen-lysozyme
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E.J.F. Franssen, R.G.M. van Amsterdam, J. Visser, F. Moolenaar, D. de Zeeuw and D.K.F. Meijer, Low molecular weight proteins as carriers for renal drug targeting: naproxen-lysozyme, Pharm. Res. 8 (1991) 1223-1230.
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(1991)
Pharm. Res.
, vol.8
, pp. 1223-1230
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Franssen, E.J.F.1
Van Amsterdam, R.G.M.2
Visser, J.3
Moolenaar, F.4
De Zeeuw, D.5
Meijer, D.K.F.6
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11
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0027166291
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Low molecular weight proteins as carriers for renal drug targeting: Naproxen coupled to lysozyme via the spacer L-lactic acid
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E.J.F. Franssen, F. Moolenaar, D. de Zeeuw and D.K.F. Meijer, Low molecular weight proteins as carriers for renal drug targeting: naproxen coupled to lysozyme via the spacer L-lactic acid, Pharm. Res. 10 (1993) 963-969.
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(1993)
Pharm. Res.
, vol.10
, pp. 963-969
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Franssen, E.J.F.1
Moolenaar, F.2
De Zeeuw, D.3
Meijer, D.K.F.4
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12
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0026552997
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Renal specific delivery of sulfamethoxazole in the rat by coupling to the low molecular weight protein lysozyme via an acid-sensitive linker
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E.J.F. Franssen, F. Moolenaar, D. de Zeeuw and D.K.F. Meijer, Renal specific delivery of sulfamethoxazole in the rat by coupling to the low molecular weight protein lysozyme via an acid-sensitive linker, Int. J. Pharm. 80 (1992) R15-R19.
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(1992)
Int. J. Pharm.
, vol.80
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Franssen, E.J.F.1
Moolenaar, F.2
De Zeeuw, D.3
Meijer, D.K.F.4
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13
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0026308311
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Limitations in the specificity of targeting asialoglycoprotein drug conjugates to hepatocytes
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G.Y. Wu and C.H. Wu (Eds), Marcel Dekker, New York, Chapter 11
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P. van der Sluijs and D.K.F. Meijer, Limitations in the specificity of targeting asialoglycoprotein drug conjugates to hepatocytes, in: G.Y. Wu and C.H. Wu (Eds), Liver Diseases. Targeted Diagnosis and Therapy using Specific Receptors and Ligands, Marcel Dekker, New York, Chapter 11, 1991, pp. 235-254.
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(1991)
Liver Diseases. Targeted Diagnosis and Therapy Using Specific Receptors and Ligands
, pp. 235-254
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Van Der Sluijs, P.1
Meijer, D.K.F.2
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14
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0025881866
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Hepatic endocytosis of various types of mannose-terminated albumins. What is important, sugar recognition, net charge, or the combination of these features
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R.W. Jansen, G. Molema, T.L. Ching, R. Oosting, G. Harms, F. Moolenaar, M.J. Hardonk and D.K.F. Meijer, Hepatic endocytosis of various types of mannose-terminated albumins. What is important, sugar recognition, net charge, or the combination of these features, J. Biol. Chem. 266 (1991) 3343-3348.
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(1991)
J. Biol. Chem.
, vol.266
, pp. 3343-3348
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Jansen, R.W.1
Molema, G.2
Ching, T.L.3
Oosting, R.4
Harms, G.5
Moolenaar, F.6
Hardonk, M.J.7
Meijer, D.K.F.8
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15
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0025935290
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Formaldehyde treated albumin contains monomeric and polymeric forms that are differently cleared by endothelial and Kupffer cells of the liver: Evidence for scavenger receptor heterogeneity
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R.W. Jansen, G. Molema, G. Harms, J.K. Kruijt, T.J.C. Van Berkel, M.J. Hardonk and D.K.F. Meijer, Formaldehyde treated albumin contains monomeric and polymeric forms that are differently cleared by endothelial and Kupffer cells of the liver: evidence for scavenger receptor heterogeneity, Biochem. Biophys. Res. Commun. 180 (1991) 3343-3348.
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(1991)
Biochem. Biophys. Res. Commun.
, vol.180
, pp. 3343-3348
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Jansen, R.W.1
Molema, G.2
Harms, G.3
Kruijt, J.K.4
Van Berkel, T.J.C.5
Hardonk, M.J.6
Meijer, D.K.F.7
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16
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0022550421
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Drug targeting to the liver with lactosylated albumins: Does the glycoprotein target the drug or is the drug targeting the glycoprotein?
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P. van der Sluijs, H.P. Bootsma, B. Postema, F. Moolenaar and D.K.F. Meijer, Drug targeting to the liver with lactosylated albumins: Does the glycoprotein target the drug or is the drug targeting the glycoprotein? Hepatology 6 (1986) 723-728.
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(1986)
Hepatology
, vol.6
, pp. 723-728
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Van Der Sluijs, P.1
Bootsma, H.P.2
Postema, B.3
Moolenaar, F.4
Meijer, D.K.F.5
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17
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0027417057
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Hepatic and intrahepatic targeting of an anti-inflammatory agent with human serum albumin and neoglycoproteins as carrier molecules
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E.J.F. Franssen, R.W. Jansen, M. Vaalburg and D.K.F. Meijer, Hepatic and intrahepatic targeting of an anti-inflammatory agent with human serum albumin and neoglycoproteins as carrier molecules, Biochem. Pharmacol. 45 (1993) 1215-1226.
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(1993)
Biochem. Pharmacol.
, vol.45
, pp. 1215-1226
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Franssen, E.J.F.1
Jansen, R.W.2
Vaalburg, M.3
Meijer, D.K.F.4
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18
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0027297728
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Coupling of the antiviral drug ara-AMP to lactosaminated albumin leads to specific uptake in rat and human hepatocytes
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R.W. Jansen, J.K. Kruijt, T.J.C. Van Berkel and D.K.F. Meijer, Coupling of the antiviral drug ara-AMP to lactosaminated albumin leads to specific uptake in rat and human hepatocytes, Hepatology 18 (1993) 146-152.
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(1993)
Hepatology
, vol.18
, pp. 146-152
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Jansen, R.W.1
Kruijt, J.K.2
Van Berkel, T.J.C.3
Meijer, D.K.F.4
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19
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0025605531
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Targeting of antiviral drugs to T4-lymphocytes. Anti-HIV activity of neoglycoprotein-AZTMP conjugates in vitro
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G. Molema, R.W. Jansen, R. Pauwels, E. de Clercq and D.K.F. Meijer, Targeting of antiviral drugs to T4-lymphocytes. Anti-HIV activity of neoglycoprotein-AZTMP conjugates in vitro, Biochem. Pharmacol. 39 (1990) 2603-2610.
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(1990)
Biochem. Pharmacol.
, vol.39
, pp. 2603-2610
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Molema, G.1
Jansen, R.W.2
Pauwels, R.3
De Clercq, E.4
Meijer, D.K.F.5
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20
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0025868871
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Neoglycoproteins as carriers for antiviral drugs: Synthesis and analysis of protein-drug conjugates
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G. Molema, R.W. Jansen, J. Visser, P. Herdewijn, F. Moolenaar and D.K.F. Meijer, Neoglycoproteins as carriers for antiviral drugs: synthesis and analysis of protein-drug conjugates, J. Med. Chem. 43 (1991) 1137-1141.
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(1991)
J. Med. Chem.
, vol.43
, pp. 1137-1141
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Molema, G.1
Jansen, R.W.2
Visser, J.3
Herdewijn, P.4
Moolenaar, F.5
Meijer, D.K.F.6
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21
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0027361964
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Novel, negatively charged, human serum albumins display potent and selective in vitro anti-human immunodeficiency virus type 1 activity
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R.W. Jansen, D. Schols, R. Pauwels, E. de Clercq and D.K.F. Meijer, Novel, negatively charged, human serum albumins display potent and selective in vitro anti-human immunodeficiency virus type 1 activity, Mol. Pharmacol. 44 (1993) 1003-1007.
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(1993)
Mol. Pharmacol.
, vol.44
, pp. 1003-1007
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Jansen, R.W.1
Schols, D.2
Pauwels, R.3
De Clercq, E.4
Meijer, D.K.F.5
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22
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0025914865
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Potent in vitro anti-human immunodeficiency virus-1 activity of modified human serum albumins
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R.W. Jansen, G. Molema, R. Pauwels, D. Schols, E. de Clercq and D.K.F. Meijer, Potent in vitro anti-human immunodeficiency virus-1 activity of modified human serum albumins, Mol. Pharmacol. 39 (1991) 818-823.
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(1991)
Mol. Pharmacol.
, vol.39
, pp. 818-823
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Jansen, R.W.1
Molema, G.2
Pauwels, R.3
Schols, D.4
De Clercq, E.5
Meijer, D.K.F.6
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23
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0027420931
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Pharmacokinetic analysis and cellular distribution of anti-HIV compound succinylated human serum albumin (suc-HSA) in vivo and in isolated perfused rat liver
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R.W. Jansen, P. Olinga, G. Harms and D.K.F. Meijer, Pharmacokinetic analysis and cellular distribution of anti-HIV compound succinylated human serum albumin (suc-HSA) in vivo and in isolated perfused rat liver, Pharm. Res. 10 (1993) 1611-1614.
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(1993)
Pharm. Res.
, vol.10
, pp. 1611-1614
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Jansen, R.W.1
Olinga, P.2
Harms, G.3
Meijer, D.K.F.4
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24
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0026704719
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Simultaneous analysis of azidothymidine and its mono-, diand triphosphate derivatives in biological fluids, tissue and cultured cells by a rapid high-performance liquid chromatographic method
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G. Molema, R.W. Jansen, J. Visser and D.K.F. Meijer, Simultaneous analysis of azidothymidine and its mono-, diand triphosphate derivatives in biological fluids, tissue and cultured cells by a rapid high-performance liquid chromatographic method, J. Chromatogr. 579 (1992) 107-114.
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(1992)
J. Chromatogr.
, vol.579
, pp. 107-114
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Molema, G.1
Jansen, R.W.2
Visser, J.3
Meijer, D.K.F.4
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26
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0028149715
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Antiviral portrait series: 4. Polysulfates as inhibitors of HIV and other enveloped viruses
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M. Witvrouw, J. Desmijter and E. De Clercq, Antiviral portrait series: 4. Polysulfates as inhibitors of HIV and other enveloped viruses, Antiviral Chem. Chemother. 5 (1994) 345-359.
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(1994)
Antiviral Chem. Chemother.
, vol.5
, pp. 345-359
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Witvrouw, M.1
Desmijter, J.2
De Clercq, E.3
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