Short term treatment with different doses of human growth hormone in adult patients with growth hormone deficiency

Endocrine Journal

Volumn 43, Issue 2, 1996, Pages 177-183

  Kato, Yuzuru ^a   Hu, Hong Yi ^a   Sohmiya, Motoi ^a  

^a SHIMANE UNIVERSITY   (Japan)

Author keywords

Adult GH deficiency; HbA1c; IGF I; IGFBP 3; NEFA

Indexed keywords

HUMAN GROWTH HORMONE;

ADULT; ARTICLE; CLINICAL ARTICLE; DOSE RESPONSE; DRUG EFFICACY; EDEMA; FEMALE; GROWTH HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; LIOTHYRONINE BLOOD LEVEL; MALE; SLEEP DISORDER; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029945090     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.43.177     Document Type: Article

References (23)

1. Raben MS (1958) Treatment of pituitary dwarf with human growth hormone. J Clin Endocrinol 18: 901-903.
2. Jørgensen JOL, Pedersen SA, Thuesen L, Jörgensen J, Ingemann-Hansen T, Skakkebaek NE, Christiansen JS (1989) Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet i: 1221-1225.
3. Salomon F, Cuneo RC, Hesp R, Sönksen PH (1989) The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 321: 1797-1803.
4. Sönksen PH, Cuneo RC, Salomon F, McGauley G, Wiles CM, Wilmshurst P, Byrne C, Hesp R, Lowy C, Weissberger A (1991) Growth hormone therapy in adults with growth hormone deficiency. Acta Paediatr Scand 379: 139-146.
5. Whitehead HM, Borenam C, Mcllrath EM, Sheridan B, Kennedy L, Atkinson AB, Hadden DR (1992) Growth hormone treatment of adults with growth hormone deficiency: Results of a 13-month placebo controlled cross-over study. Clin Endocrinol (Oxf) 36: 45-52.
6. Bengtsson B-Å, Edén S, Lonn L, Kvist H, Stokland A, Lindstedt G, Bosaeus I, Toll J, Sjorstrom L, Isaksson OGP (1993) Treatment of adults with growth hormone (GH) deficiency witth recombinant human GH. J Clin Endocrinol Metab 76: 309-317.
7. Mardh G, Lundin K, Borg G, Jönsson B, Lindeberg A (1994) Growth hormone replacement therapy in adult hypopituitary patients with growth hormone deficiency: Combined data from 12 European placebo-controlled clinical trials. Endocrinol Metab 1 (Suppl A): 43-49.
8. Rosen T, Johannsson G, Hallgren P, Caidahl K, Bosaeus I, Bengtsson B-Å (1994) Beneficial effects of 12 months replacement therapy with recombinant human growth hormone to growth hormone deficient adults. Endocrinol Metab 1: 55-66.
9. Marcus R, Butturfield G, Holloway L, Gilliland, Baylink DJ, Hintz RJ, Sherman BM (1990) Effects of short term administration of recombinant human growth hormone to elderly people. J Clin Endocrinol Metab 70: 519-527.
10. Moller J, Jørgensen JO, Lauersen T, Frysryl J, Naeaa RW, Orskov H, Christiansen JS (1993) Growth hormone dose regimens in adult GH deficiency: Effects on biochemical growth markers and metabolic parameters. Clin Endocrinol (Oxf) 39: 403-408.
11. Sohmiya M, Kato Y (1992) Renal clearance, metabolic clearance rate, and half-life of human growth hormone in young and aged subjects. J Clin Endocrinol Metab 75: 1487-1490.
12. Yamamoto H, Sohmiya M, Oka N, Kato Y (1991) Effects of aging and sex on plasma insulin-like growth factor I (IGF-I) levels in normal adults. Acta Endocrinol (Copenh) 124: 479-500.
13. Hatazoe T, Murakami Y, Umaki I, Sohmiya M, Hu H-Y, Kato Y (1995) Isolated adrenocorticotropic hormone deficiency associated with growth hormone deficiency and empty sella. Int Med 34: 688-691.
14. Notsu K, Oka N, Masaki Y, Furuya H, Kato Y (1991) Plasma free triiodothyronine response to thyrotropin releasing hormone to predict the remission of Graves' disease treated with antithyroid drugs. J Clin Endocrinol Metab 73: 396-400.
15. Yamamoto H, Kato Y (1993) Relationship between plasma insulin-like growth factor I (IGF-I) levels and body mass index (BMI) in adults. Endocr J 40: 41-45.
16. Raben MS, Hollenberg CH (1959) Effect of growth hormone on plasma fatty acids. J Clin Invest 38: 484-188.
17. Hintz RL, Wilson DM, Finno J, Rosenfeld RG, Bennett A, McClellan B, Swift R (1982) Biosynthetic methionyl human growth hormone is biologically active in adult man. Lancet i: 1276-1279.
18. Edén S, Wiklund O, Oscarsson J, Rosen T, Bengtsson B-Å (1993) Growth hormone treatment of growth hormone-deficient adults results in a marked increase in Lp (a) and HDL-cholesterol concentrations. Arteriosder Thromb 13: 296-301.
19. Irie M, Shizume K, Takano K, Kato Y, Tanaka T, Chihara K, Miyachi Y, Snimizu N (1995) Growth hormone replacement therapy in adults with growth hormone deficiency: A double-blind, placebo-controlled crossover trial in Japan. Endocrinol Metab 2 (Suppl B): 17-23.
20. Rosen T, Bengtsson B-Å (1990) Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 336: 285-288.
21. Sato T, Suzuki Y, Taketani T, Ishiguro K, Masuyama T, Takata I, Sano M, Kawashima H, Koizumi S, Nakajima H (1977) Enhanced peripheral conversion of thyroxine to tiiodothyronine during hGH therapy in GH deficient children. J Clin Endocrinol Metab 45: 324-329.
22. Cuneo RC, Salmon F, Wilmshurst P, Byrne C, Wiles CM, Hesp R, Sönksen PH (1991) Cardiovascular effects of growth hormone treatment in growth hormone-deficient adults: Stimulation of the renin-aldosterone system. Clin Sci 81: 587-592.
23. Ho KY, Weissberger AJ (1990) The antinatriuretic action of biosynthetic human growth hormone in man involves activation of the renin-angiotensin system. Metabolism 39: 133-137.