Mutation of the VHL gene is associated exclusively with the development of non-papillary renal cell carcinomas

Journal of Pathology

Volumn 179, Issue 2, 1996, Pages 157-161

  Kenck, Christiane ^a   Wilhelm, Mónica ^a   Bugert, Peter ^a   Staehler, Gerd ^a   Kovacs, Gyula ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

kidney cancer; SSCP analysis; VHL mutation

Indexed keywords

HETERODUPLEX;

ARTICLE; CELL MIGRATION; CHROMOSOME 3P; CHROMOSOME DELETION; DNA SEQUENCE; GENE FREQUENCY; GENE MUTATION; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; KIDNEY PARENCHYMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM;

BASE SEQUENCE; CARCINOMA, RENAL CELL; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 3; HIPPEL-LINDAU DISEASE; HUMANS; KIDNEY NEOPLASMS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACID HETERODUPLEXES; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; SEQUENCE ANALYSIS, DNA;

EID: 0029944971     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199606)179:2<157::AID-PATH557>3.0.CO;2-S     Document Type: Article

References (20)

1. Kovacs G. Molecular cytogenetics of renal cell tumors. Adv Cancer Res 1993; 62: 89-124.
2. Kovacs G, Frisch S. Clonal chromosome abnormalities in tumour cells from patients with sporadic renal cell carcinomas. Cancer Res 1989; 49: 651-659.
3. Presti JC, Rao PH, Chen Q, et al. Histopathological, cytogenetic, and molecular characterization of renal cortical tumors. Cancer Res 1991; 51: 1544-1552.
4. Kovacs G, Wilkens L, Papp T, DeRiese W. Differentiation between papillary and nonpapillary renal cell carcinomas by DNA analysis. J Natl Cancer Inst 1989; 81: 527-530.
5. Branch H, Tory K, Linehan WM, Weaver DM, Lovell MA, Zbar B. Molecular analysis of the short arm of chromosome 3 in five renal oncocytomas. J Urol 1990; 143: 622-624.
6. Speicher MR, Schoell B, Du Manoir S, et al. Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization. Am J Pathol 1994; 145: 356-364.
7. Latif F, Tory K, Gnarra J, et al. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 1993; 260: 1317-1320.
8. McKusick VA. Mendelian Inheritance in Man. 7th edn. Johns Hopkins University Press, 1986; 758.
9. Gnarra JR. Tory K, Weng Y, et al. Mutations of the VHL tumor suppressor gene in renal carcinoma. Nature Genet 1994; 7: 85-89.
10. Shuin T, Kondo K, Torigoe S, et al. Frequent mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res 1994; 54: 2852-2855.
11. Whaley JM, Naglich J, Gelbert L, et al. Germ-line mutations in the von Hippel-Lindau tumor-suppressor gene are similar to somatic von Hippel-Lindau aberrations in sporadic renal cell carcinomas. Am J Hum Genet 1994; 55: 1093-1102.
12. Foster K, Prowse A, van den Berg A, et al. Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familiar clear cell renal carcinoma. Hum Mol Genet 1994; 12: 2169-2173.
13. Kovacs G, Szücs S, DeRiese W, Baumgartel W. Specific chromosome aberration in human renal cell carcinoma. Int J Cancer 1987; 40: 171-178.
14. Yamakawa K, Morita R, Takahashi E, Hori T, Ihikawa J, Nakamura Y. A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma. Cancer Res 1991, 51: 4707-4711.
15. Lubinski J, Hadaczek P, Podolski J, et al. Common regions of deletion in chromosome regions 3p12 and 3p14.2 in primary clear cell renal carcinomas. Cancer Res 1994; 54: 3710-3713.
16. Sekido Y, Bader S, Latif F, et al. Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines. Oncogene 1994; 9: 1599-1604.
17. Kanno H, Kondo K, Ito S, et al. Somatic mutations of the von Hippel-Lindau tumor suppressor gene in sporadic central nervous system hemangioblastomas. Cancer Res 1994; 54: 4845-4847.
18. Kovacs G, Emanuel A, Neumann HPH, Kung H. Cytogenetics of renal cell carcinomas associated with von Hippel-Lindau disease. Genes Chromosomes Cancer 1991; 3: 256-262,
19. Sanchez Y, El-Naggar A, Pathak S, Killary AM. A tumor suppressor locus within 3p14-p12 mediates rapid cell death of renal cell carcinoma in vivo. Proc Natl Acad Sci USA 1994; 91: 3383-3387.
20. Oda H, Nakatsuru Y, Ishikawa T. Mutations of the p53 gene and p53 protein overexpression are associated with sarcomatoid transformation in renal cell carcinomas. Cancer Res 1995; 55: 658-662.