Intratumoral administration of Sizofiran activates Langerhans cell and T-cell infiltration in cervical cancer

Clinical Immunology and Immunopathology

Volumn 79, Issue 1, 1996, Pages 79-86

  Nakano, Takashi ^a   Oka, Kuniyuki ^a   Hanba, Keiko ^a   Morita, Shinroku ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

SCHIZOPHYLLAN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRAMUSCULAR DRUG ADMINISTRATION; INTRATUMORAL DRUG ADMINISTRATION; LANGERHANS CELL; LYMPHOCYTIC INFILTRATION; PRIORITY JOURNAL; PROGNOSIS; UTERINE CERVIX CANCER;

EID: 0029944636     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1996.0053     Document Type: Article

References (30)

1. Katz, S. I., Cooper, K. D., Iijima, M., and Tsuchida, T., The role of Langerhans cells in antigen presentation. J Invest. Dermatol. 85, 96s-8s, 1985.
2. Nakano, T., Oka, K, Arai, T., Morita, S., and Tsunemoto, H., Prognostic significance of Langerhans' cell infiltration in radiation therapy for squamous cell carcinoma of the uterine cervix. Arch. Pathol. Lab. Med. 113, 507-511, 1989.
3. Oka, K., Nakano, T., and Arai, T., Adenocarcinoma of the cervix treated with radiation alone: Prognostic significance of S-100 protein and vimentin immunostaining. Obstet. Gynecol. 79, 1992.
4. Nakano, T., Oka, K., Takahashi, K., Morita, S., and Arai, T., Roles of Langerhans' cells and T-lymphocytes infiltrating cancer tissues in patients treated by radiation therapy for cervical cancer. Cancer 70, 2839-2844, 1992.
5. Furukawa, T., Watanabe, S., Kodama, T., Sato, Y., Shimosat, Y., and Suematsu, K., T-zone histiocytes in adenocarcinoma of the lung in relation to postoperative prognosis. Cancer 56, 2651-2656, 1985.
6. Tsujitani, S., Furukawa, T., Tamada, R., Okamura, T., Yasumoto, Y., and Sugimachi, K., Langerhans cell and prognosis in patients with gastric carcinoma. Cancer 59, 501-505, 1987.
7. Schroder, S., Schwarz, W., Rehpenning, W., Loning, T., and Bocher, W., Dendritic/Langerhans cells and prognosis in patients with papillary thyroid carcinomas. Am. J. Clin. Pathol. 89, 295-300, 1988.
8. Sugawara, I., Lee, C. K., and Wong, M., schizophyllan (SPG)-treated macrophages and anti-tumor activities against syngeneic allogeneic tumor cells. I. Characteristic of SPG-treated macrophages. Cancer Immunol. Immunother. 16, 137-144, 1984.
9. Mizuhira, V., Ono, M., Yokofujita, J., Kinoshita, M., Asano, T., Hase, T., and Amemiya, K., Histological and cytochemical studies on the distribution of schizophyllan glucan (SPG) in cancer-inoculated animals. I. Differences in distribution and antitumor activity of H-SPG in sarcoma-180 inoculated females between ICR and DBA mice. Acta Histochem. Cytochem. 18, 221-254, 1985.
10. Komatsu, N., Okubo, S., Kikumoto, S., Kimura, K., Sato, G., and Sasaki, S., Host-mediated antitumoraction of Schizophyllan: A glucan produced by Schizophyllum commune. Gann 60, 137-144, 1969.
11. Mashida, H., and Matsunaga, K., In vitro activation of human adherent cells by a glucan, Schizophyllan. J. Exp. Med. 53, 195-198, 1983.
12. Okamura, K., Suzuki, M., Chihara, T., Fujiwara, A., Fukuda, T., and Goto, S., Clinical evaluation of sizofiran combined with irradiation in patients with cervical cancer. Biotherapy 1, 103-107, 1989.
13. Fujimoto, S., Furue, H., Kimura, T., Kondo, T., Orita, K., Taguuchi, T., Yoshida, K., and Ogawa, N., Clinical evaluation of Shizophyllan adjuvant immunochemotherapy for patients with resectable gastric cancer-arandomized controlled trial. Jpn. J. Surg. 14, 286-292, 1984.
14. Poulsen, H. E., Taylor, C. W., and Sobin, L. H., "Histological Typing of Female Genital Tract Tumours," pp. 55-59, WHO, Geneva, 1955.
15. "Annual Report on the Results of Treatment in Carcinoma of the Uterus Vagina and Ovary," Vol. 16, FIGO, Radiumhemmet, Sweden, 1976.
16. West, K. P., Warford, A., Fray, L. A., Campbell, A. C., and Lauder, I., The demonstration of B-cell, T-cell and myeloid antigens in paraffin sections. J. Pathol. 159, 89-101, 1986.
17. Hsu, S. M., Raine, L., and Fanger, H., Use of avidin-biotin- peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures. J. Histochem. Cytochem. 29, 577-580, 1981.
18. Shimokawara, I., Imamura, M., Yamanaka, N., Ishii, Y., and Kikuchi, K., Identification of Lymphocyte subpopulations in human breast cancer tissues and its significance: An immunoperoxidase study with anti-human T- and B-cell sera. Cancer 49, 1456-1464, 1982.
19. Sonoda, Y., Miyazaki, T., and Asano, S., Increased Langerhans cells and related cells in mesenteric lymph nodes of DNCB-sensitive mice. Arch. Dermatol. Res. 278, 68-73, 1985.
20. Bartosik, J., Andersson, A., Axelsson, S., Falck, B., and Ringberg, A., Direct evidence for the cytomembrane derivation of Birbeck granules: The cytomembrane-sandwich effect. Acta Dermatol. Venereol. 65, 157-160, 1985.
21. Bartosik, J., Cytomembrane-derived Birbeck granules transport horseradish peroxidase to the endosomal compartment in the human Langerhans cells. J. Invest. Dermatol. 99, 53-58, 1992.
22. Takahashi, S., and Hashimoto, K., Derivation of Langerhans cell granules from cytomembrane. J. Invest. Dermatol. 84, 469-471, 1985.
23. Strossel, H., Koch, F., Kampgen, E., Stoger, P., Lenz, A., Heufler, C., Romani, N., and Schuler, G., Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells. J. Exp. Med. 172, 1471-1482, 1990.
24. Tsujitani, S., Okamura, T., Baba, H., Korenaga, D., Haraguchi, M., and Sugimachi, K., Endoscopic intratumoral injection of OK-432 and Langerhans cell in patients with gastric carcinoma. Cancer 61, 1749-1753, 1988.
25. Sakagami, Y., Mizoguchi, Y., Shin, T., Seki, S., Kobayashi, K., Morisawa, S., and Yamamoto, S., Effects of an anti-tumor polysaccharide, shizophyllan, on interferon-γ and interleukin 2 production by peripheral blood mononuclear cells. Biochem. Biophys. Res. Commun. 155, 650-655, 1988.
26. Black, M. M., Freeman, C., Mork, T., Harvel, S., and Cutler, S. J., Prognostic significance of microscopic structure of gastric carcinomas and their regional lymph nodes. Cancer 27, 703-711, 1970.
27. Watanabe, H., Enjoji, M., and Imai, T., Gastric carcinoma with lymphoid stroma. Cancer 38, 232-243, 1976.
28. van Nagel, J. R., Donaldson, E. S., Wood, E. G., and Parker, J. C. P., The significance of vascular invasion and lymphocytic infiltration in invasive cervical cancer. Cancer 41, 228-234, 1978.
29. Macatonia, S. E., Knigh, S. C., Edwards, A. J., Griffiths, S., and Fryer, P., Lacalization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. J. Exp. Med. 166, 1654-1667, 1987.
30. Steinman, R. M., The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9, 271-296, 1991.