Further novel milbemycin antibiotics from Streptomyces sp. E225 fermentation, isolation and structure elucidation

Journal of Antibiotics

Volumn 49, Issue 3, 1996, Pages 272-280

  Baker, Geoff H ^a   Blanchflower, Simon E ^a,b   Dorgan, Roderick J J ^a,b   Everett, Jeremy R ^a,b   Manger, Brian R ^a,b   Reading, Christopher R ^a   Readshaw, Simon A ^a   Shelley, Peter ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MILBEMYCIN DERIVATIVE; UNCLASSIFIED DRUG; VM 44867; VM 44868; VM 47704; VM 48130; VM 48633; VM 48640; VM 48641; VM 48642; VM 54168; VM 54339;

ANTHELMINTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG ISOLATION; DRUG STRUCTURE; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES;

EID: 0029944531     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.49.272     Document Type: Article

References (8)

1. DAVIES, H. G. & R. H. GREEN: Avermectins and milbemycins part I. Chem. Soc. Rev. 20: 211-269, 1991
2. DAVIES, H. G. & R. H. GREEN: Avermectins and milbemycins part II. Chem. Soc. Rev. 20: 271-339, 1991
3. HOOD, J. D.; R. M. BANKS, M. D. BREWER, J. P. FISH, B. R. MANGER & M. E. POULTON: A novel series of milbemycin antibiotics from Streptomyces strain E225. I. Discovery, fermentation and anthelmintic activity. J. Antibiotics 42: 1593-1598, 1989
4. BAKER, G. H.; R. J. J. DORGAN, J. R. EVERETT, J. D. HOOD & M. E. POULTON: A novel series of milbemycin antibiotics from Streptomyces strain E225. II. Isolation, characterisation, structure elucidation and solution conformations. J. Antibiotics 43: 1069-1076, 1990
5. BREMSER, W. et al.: Chemical Shift Ranges in Carbon-13 NMR Spectroscopy, Verlag Chemie, 1982
6. 3 J. Chem. Soc. Perkin Trans. I: 2171-2181, 1987
7. CARTER, G. T.; J. A. NIETSCHE, M. R. HERTZ, D. R. WILLIAMS, M. M. SIEGEL, G. O. MORTON, J. C. JAMES & D. B. BORDERS: LL-F28249 Antibiotic complex: A new family of antiparasitic macrocyclic lactones. Isolation, characterisation and structures of LL-F28249 α, β, γ, λ. J. Antibiotics 41: 519-529, 1988
8. MAXELL, M. A.; B F. BISHOP, P. BRYCE, K. A. F. GRATION, H. KARA, R. A. MONDAY, M. S. PACEY, D. A. PERRY, Y. KOJIMA, H. MAEDA, S. NISHIYAMA, J. TONE & L. H. HUANG: C-13β-Acyloxymilbemycins, a new family of macrolides. Discovery, structural determination and biological properties. J. Antibiotics 45: 659-670, 1992